News | May 20, 2009

SAVI Breast Cancer Radiation Device Expands Availability of Brachytherapy, Studies Says

May 20, 2009 - Breast cancer radiation with the SAVI applicator provides positive cosmetic outcomes and the multicatheter device allows greater planning flexibility, technically easier insertion, according to two new studies on breast conservation therapy patients with small breasts, small tumor beds and minimal distance between the lumpectomy cavity and skin surface.

The studies, which were conducted at Moores Cancer Center at University of California, San Diego, will be presented from the podium at the American Brachytherapy Society’s annual meeting, May 31-June 2, 2009, in Toronto.

SAVI is implemented as part of breast conservation therapy, which encompasses surgery to remove the breast cancer and follow-up radiation delivered inside the breast in a procedure known as breast brachytherapy. SAVI treatment is completed in just five days, compared to the six weeks of treatment, five days a week, that are typically required by traditional, external-beam radiation treatment.

The first study was led by Daniel Scanderbeg, Ph.D., and the second study was led by Catheryn Yashar, M.D., associate professor and chief of breast and gynecological services in the UCSD Department of Radiation Oncology.

Dr. Scanderbeg’s study retrospectively evaluated 13 breast cancer patients who chose breast conservation therapy and were successfully treated with SAVI. None of the 13 was eligible for the older form of brachytherapy because they had breast cancer tumor cavities less than 7 mm from the skin surface. That distance is too small for use of the balloon device, because it cannot modulate the dose to minimize skin damage if the cavity is less than 7 mm from the skin surface.

SAVI is not limited by restrictions on skin spacing, because its design enables physicians to direct the radiation dose away from the skin.

According to the study, SAVI provided outstanding coverage of the breast cancer tumor bed while simultaneously sparing normal tissue from radiation. There were no infections, persistent seromas or local recurrences of cancer among any of the patients. Researchers called the cosmetic outcomes “outstanding.”

“SAVI removes the obstacles associated with balloon brachytherapy, namely the inability to customize the radiation dose to avoid damage to critical structures in women with small breasts, small tumor beds, or narrow skin bridges,” said Dr. Scanderbeg. “With this increased flexibility, SAVI allows a greater proportion of women to choose APBI than was previously possible.”

The second study reviewed early clinical experiences with SAVI in 40 breast cancer patients. Nearly half were not candidates for balloon brachytherapy due to skin spacing or small tumor size.

Researchers concluded that the multicatheter device allowed greater planning flexibility, technically easier insertion and minimal exposure to normal tissue.

“As the popularity of APBI has increased, SAVI has allowed us to treat tumor beds as small as 5 cc’s. This device expands the number of women who benefit from accelerated treatment in the form of breast brachytherapy,” said Dr. Yashar.

Patient tolerance among the 40 patients in Yashar’s group was also excellent. There were no symptomatic seromas and the infection rate was 5 percent - lower than published infection rates for balloon brachytherapy.

The SAVI applicator is made by Cianna Medical, Inc. Moores Cancer Center at UC San Diego was the second medical facility in the nation to offer SAVI for breast brachytherapy.

For more information: www.ciannamedical.com

Related Content

Merit Medical Completes Acquisition of Cianna Medical
News | Women's Health | November 14, 2018
Disposable device manufacturer Merit Medical Systems Inc. announced the closing of a definitive merger agreement to...
News | Brachytherapy Systems, Women's Healthcare | October 25, 2018
iCAD Inc. announced new clinical research demonstrating positive outcomes supporting the use of the Xoft Axxent...
Xoft Electronic Brachytherapy System Effective Long-Term for Early-Stage Breast Cancer
News | Brachytherapy Systems, Women's Healthcare | October 02, 2018
Breast cancer recurrence rates for patients treated with the Xoft Axxent Electronic Brachytherapy (eBx) System that...
​ITN Celebrates World Cancer Day 2018
News | Radiation Oncology | February 01, 2018
World Cancer Day takes place annually on Feb.
Intraoperative Radiotherapy Provides Lifetime Cost Savings, Health Benefits for Early-Stage Breast Cancer Treatment
News | Brachytherapy Systems, Women's Healthcare | December 19, 2017
iCAD Inc. announced the results of a landmark study that showed the benefits of adjunct intraoperative radiation...
Cleveland Clinic Leads Development of New Guidelines for Radiation in Breast Cancer
News | Brachytherapy Systems, Women's Healthcare | October 31, 2017
October 31, 2017 — Cleveland Clinic researcher Chirag Shah, M.D., recently led the development of updated guidelines
International Trial Confirms Safety, Effectiveness of High-Dose Brachytherapy Plus Pelvic Radiation for Cervical Cancer
News | Brachytherapy Systems, Women's Healthcare | October 04, 2017
Findings from a new multicenter, international clinical trial confirm the effectiveness of high-dose brachytherapy or...
Pelvic Radiation Confirmed as Standard of Care for High-Risk, Early-Stage Endometrial Cancer
News | Brachytherapy Systems, Women's Healthcare | September 28, 2017
In a new phase III trial report, recurrence-free and overall survival rates for women with stage I-II high-risk...
China FDA Approves Xoft Axxent Balloon Applicators for Early-Stage Breast Cancer
News | Brachytherapy Systems, Women's Healthcare | August 30, 2017
iCAD Inc. announced that the company’s Xoft Axxent balloon applicators have received approval from the China Food...