News | Mammography | November 13, 2015

Researchers Personalizing Breast Cancer Subtype Detection Strategies

Joint Texas-Chicago team will combine mammography features with blood-based biomarkers to more precisely predict breast cancer risk

breast cancer subtypes, early detection, risk prediction, biomarkers, Houston Methodist, Randa El-Zein

Image courtesy of Barco

November 13, 2015 — The National Cancer Institute awarded Houston Methodist investigator Randa El-Zein, M.B., Ch.B., Ph.D., a $2.8 million, five-year U01 grant to combine mammography features with blood-based biomarkers to more precisely predict a woman’s risk for breast cancer-specific subtypes.

El-Zein and a team from The University of Texas MD Anderson Cancer Center and University of Chicago believe that high-risk breast cancer patients have an increased amount of genetic instabilities that often can be detected by measuring changes in specific biomarkers. The investigators will use unique features computationally determined from mammograms to identify and develop subtype-specific premalignant signatures for early detection. They then will use molecular blood biomarkers to further improve the precision of those imaging signatures.

Mammography has been the mainstay for early detection of breast cancer for more than four decades, but a substantial number of patients with image-detected breast cancer still die from the disease or receive unnecessary intervention. Researchers hope to identify the premalignant signatures of any given breast cancer subtype, even prior to disease detection. While one in eight women will be diagnosed with breast cancer in her lifetime, these cancers present in distinct subtypes, based on genomic alterations.

If successful, this approach would expand mammography from a tool that screens for the presence of cancer to a true early detection device that identifies parenchymal hallmarks of precancerous changes. The investigative team also includes Isabelle Bedrosian, M.D., F.A.C.S., MD Anderson and Maryellen Giger, Ph.D., University of Chicago.

For more information:

Related Content

Philips Azurion Image-Guided Therapy Platform Improves Clinical Workflow for Interventional Procedures
News | Angiography | November 15, 2017
Philips announced the results of a comprehensive, independent, two-year study demonstrating the clinical workflow...
Study Unveils Brain Changes During Extended Space Missions
News | Neuro Imaging | November 14, 2017
November 14, 2017 — More people today are poised to explore space than ever before; those who do will experience the
Synthetic CT Images Suitable for Prostate Cancer Radiotherapy Planning
News | Treatment Planning | November 14, 2017
Spectronic Medical announced that new data for their MRIPlanner software, generating synthetic computed tomography (sCT...
Biop Medical Launches Cervical Cancer Diagnosis Technology at MEDICA 2017

Biop Medical cervical cancer detection system

Technology | Women's Health | November 13, 2017
November 13, 2017 — Biop Medical announced it will present its point-of-care...
Kansas City Radiology Center Employs iCAD PowerLook Tomo Detection for DBT
News | Computer-Aided Detection Software | November 10, 2017
November 10, 2017 — Imaging for Women, a leading radiology center in Kansas City, Mo., announced it is now using iCAD
Kubtec Brings Image Analytics Capabilities to Tomosynthesis Specimen Imaging Systems
News | Mammography | November 10, 2017
Kubtec announced it will be showcasing new image analytics capabilities on its advanced tomosynthesis specimen imaging...
Siemens Healthineers Introduces Share360 Tailored Service Portfolio
News | Imaging | November 10, 2017
November 10, 2017 — To address the specific needs of...
Fujifilm Highlights Women's Health and Pediatrics at RSNA 2017
News | Information Technology | November 08, 2017
November 8, 2017 — Fujifilm Healthcare will showcase a variety of imaging and information technology solutions at the
CureMetrix Expands Medical Advisory Board
News | Computer-Aided Detection Software | November 08, 2017
November 8, 2017 — CureMetrix, a company developing...
ICPME Makes EQUIP Mammography Inspection CME/CE Webinar Available Online
News | Mammography | November 08, 2017
November 8, 2017 — In conjunction with Brea...
Overlay Init