News | May 28, 2015

Recurrence of Prostate Cancer Detected Earlier With Innovative PSMA-ligand PET/CT

Higher than normal PSMA levels detected in 89.5 percent of trial patients

prostate cancer, recurrence, PET/CT, PSMA-ligand, Matthias Eiber, Ga-68

May 28, 2015 — The novel Ga-68-PSMA-ligand positron emission tomography/computed tomography (PET/CT) has substantially higher detection rates of prostate-specific membrane antigen (PSMA) in patients with biochemical recurrence after radical prostatectomy, according to a recent study. Discovering a recurrence early can strongly influence further clinical management, so it is especially noteworthy that this hybrid PSMA-ligand identified a large number of positive findings in the clinically important range of low PSA-values (<0.5ng/mL).

According to the Centers for Disease Control (CDC), prostate cancer is the most common cancer among men in the United States, after non-melanoma skin cancer. While many men with prostate cancer die from other causes, prostate cancer remains one of the leading causes of cancer death among men of all races. Treatment and survival after recurrence depend on many factors, but early detection of the recurrence is certainly key.

Matthias Eiber, M.D., corresponding author of the study, which was reported in The Journal of Nuclear Medicine, noted, "The study is the first to examine this highly promising PET tracer in the use of a homogeneous patient collective consisting of only those with biochemical recurrence after radical prostatectomy. It found superb detection rates compared to other tracers, like choline, or imaging modalities, like MRI [magnetic resonance imaging]. For patients, this means that the referring urologist can receive earlier and more precise information about the site and extent of metastatic disease. Physicians will also be better able estimate whether a PSMA-PET scan might be useful in a specific setting."

The study evaluated 248 patients with biochemical recurrence (median PSA level of 1.99ng/mL and a range of 0.2-59.4ng/mL) after radical prostatectomy. All were given contrast-enhanced PET/CT after injection of 155±27MBq Ga-68-PSMA-ligand. The detection rates were then correlated with PSA-level and PSA-kinetics. Influencing factors that were assessed include anti-hormonal treatment and primary Gleason score, as well as the contribution of PET and morphological imaging to the final diagnosis.

For 222 (89.5 percent) of the patients, the test detected higher than normal levels of PSMA. Whereas detection rates increased with higher PSA-velocity, no significant association could be found for PSA doubling-time.

In addition, Ga-68-PSMA-ligand PET (compared to CT) exclusively provided pathological findings in 81 (32.7 percent) patients. In 61 (24.6 percent) patients, it exclusively identified additional involved regions. And, for those with a higher Gleason score, detection efficacy was significantly increased (P = 0.0190).

Eiber stated, "These findings will certainly enhance the use of PET in the diagnostic workup of patients with recurrent prostate cancer. When regulatory hurdles and reimbursement issues are overcome, this tracer might gain significant acceptance beyond Europe."

For more information: www.snmmi.org

Related Content

Technology | Focused Ultrasound Therapy | June 19, 2018
EDAP TMS SA has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its Focal One device for...
New Prostate Cancer Radiotherapy Technique Aims to Preserve Sexual Function
News | Radiation Therapy | June 18, 2018
A multicenter clinical trial being led by UT Southwestern physicians is testing a technique for sparing nerve bundles...
Hitachi Medical Systems Europe Named Imaging Supplier for London Prostate Cancer Program
News | Prostate Cancer | June 14, 2018
Hitachi Medical Systems Europe has been awarded the contract to supply six ultrasound systems as part of the RAPID...
PET/CT Changes Care for 59 Percent of Suspected Recurrent Prostate Cancer Cases
News | Prostate Cancer | June 13, 2018
A recently presented investigational clinical trial evaluated the impact of 18F fluciclovine positron emission...
News | Brachytherapy Systems | June 07, 2018
IsoRay Inc. announced the upcoming release of its Build-Blu delivery system for real-time prostate brachytherapy.
Nuclear imaging scan showing very good tissue delineation. Scan performed on a Biograph Vision positron emission tomography/computed tomography (PET-CT) system from Siemens Healthineers.

Nuclear imaging scan showing very good tissue delineation. It offers crisp overall image quality and sharply delineates the muscle and fat planes, vertebral margins and end plates, billiary radicals, renal calyces, aortic wall and papillary muscles of the heart. Scan performed on a Biograph Vision positron emission tomography/computed tomography (PET-CT) system from Siemens Healthineers.

Technology | PET-CT | June 05, 2018
June 5, 2018 — The U.S.
Emerging Trends in Nuclear Medicine
Feature | Nuclear Imaging | June 04, 2018 | By Jeff Zagoudis
Nuclear imaging and its various modalities have long played an important role in the diagnosis and treatment of numer
News | Computed Tomography (CT) | May 21, 2018
The Istituto Oncologico Veneto (IOV) in Padua, Italy, has acquired MILabs’ latest-generation Versatile Emission...
New Studies Highlight MRI Use for Prostate Cancer Screening and Management
News | Magnetic Resonance Imaging (MRI) | May 21, 2018
Three new studies presented at the 113th annual meeting of the American Urological Association (AUA) highlight the...
PET Imaging Agent Could Provide Early Diagnosis of Rheumatoid Arthritis

Coronal 18F-FEDAC PET/CT section of a mouse with collagen-induced arthritis. (A) On day 23 and day 37, increased uptake is noted in the front and hind paws of this mouse with collagen-induced arthritis. (B) Predictive performance of day 23 18F-FEDAC uptake for the development of clinical arthritis. ROC = receiver operating characteristic; Sn = sensitivity; Sp = specificity. Credit: Seoul National University and Ewha Womans University, Seoul, South Korea

News | PET Imaging | May 17, 2018
A novel positron emission tomography (PET) tracer developed by Korean researchers can visualize joint inflammation and...
Overlay Init