News | May 28, 2015

Recurrence of Prostate Cancer Detected Earlier With Innovative PSMA-ligand PET/CT

Higher than normal PSMA levels detected in 89.5 percent of trial patients

prostate cancer, recurrence, PET/CT, PSMA-ligand, Matthias Eiber, Ga-68

May 28, 2015 — The novel Ga-68-PSMA-ligand positron emission tomography/computed tomography (PET/CT) has substantially higher detection rates of prostate-specific membrane antigen (PSMA) in patients with biochemical recurrence after radical prostatectomy, according to a recent study. Discovering a recurrence early can strongly influence further clinical management, so it is especially noteworthy that this hybrid PSMA-ligand identified a large number of positive findings in the clinically important range of low PSA-values (<0.5ng/mL).

According to the Centers for Disease Control (CDC), prostate cancer is the most common cancer among men in the United States, after non-melanoma skin cancer. While many men with prostate cancer die from other causes, prostate cancer remains one of the leading causes of cancer death among men of all races. Treatment and survival after recurrence depend on many factors, but early detection of the recurrence is certainly key.

Matthias Eiber, M.D., corresponding author of the study, which was reported in The Journal of Nuclear Medicine, noted, "The study is the first to examine this highly promising PET tracer in the use of a homogeneous patient collective consisting of only those with biochemical recurrence after radical prostatectomy. It found superb detection rates compared to other tracers, like choline, or imaging modalities, like MRI [magnetic resonance imaging]. For patients, this means that the referring urologist can receive earlier and more precise information about the site and extent of metastatic disease. Physicians will also be better able estimate whether a PSMA-PET scan might be useful in a specific setting."

The study evaluated 248 patients with biochemical recurrence (median PSA level of 1.99ng/mL and a range of 0.2-59.4ng/mL) after radical prostatectomy. All were given contrast-enhanced PET/CT after injection of 155±27MBq Ga-68-PSMA-ligand. The detection rates were then correlated with PSA-level and PSA-kinetics. Influencing factors that were assessed include anti-hormonal treatment and primary Gleason score, as well as the contribution of PET and morphological imaging to the final diagnosis.

For 222 (89.5 percent) of the patients, the test detected higher than normal levels of PSMA. Whereas detection rates increased with higher PSA-velocity, no significant association could be found for PSA doubling-time.

In addition, Ga-68-PSMA-ligand PET (compared to CT) exclusively provided pathological findings in 81 (32.7 percent) patients. In 61 (24.6 percent) patients, it exclusively identified additional involved regions. And, for those with a higher Gleason score, detection efficacy was significantly increased (P = 0.0190).

Eiber stated, "These findings will certainly enhance the use of PET in the diagnostic workup of patients with recurrent prostate cancer. When regulatory hurdles and reimbursement issues are overcome, this tracer might gain significant acceptance beyond Europe."

For more information: www.snmmi.org

Related Content

PET Tracer Gauges Effectiveness of Promising Alzheimer's Treatment

Longitudinal PET imaging with 18F-AV45. PET imaging shows the average 18F-AV45 uptake per animal group at 8 and 13 months of age. A significant interaction of genotype treatment was observed in the cortex (p = 0.0248), hippocampus (p = 0.0071) and thalamus (p = 0.0084), indicating reduced [18F]-AV45 uptake in BACE1 inhibited transgenic mice. Credit: MICA, University of Antwerp, Belgium.

News | Radiopharmaceuticals and Tracers | December 28, 2017
In the December featured basic science article in The Journal of Nuclear Medicine, Belgian researchers report on the...
Vital Unveils Newest Vitrea Advanced Visualization Release at RSNA 2017
Technology | Advanced Visualization | December 04, 2017
Vital Images unveiled the newest version of Vitrea Advanced Visualization software, the cornerstone of its imaging...
Synthetic CT Images Suitable for Prostate Cancer Radiotherapy Planning
News | Treatment Planning | November 14, 2017
Spectronic Medical announced that new data for their MRIPlanner software, generating synthetic computed tomography (sCT...
Proton Therapy Shows Promising Clinical Benefits for Esophageal, Prostate and Breast Cancer
News | Proton Therapy | October 30, 2017
The National Association for Proton Therapy (NAPT) announced a number of clinical papers showing promising results were...
Michael J. Fox Foundation and Tau Consortium Developing PET Tracers for Neurodegenerative Disease
News | Radiopharmaceuticals and Tracers | October 27, 2017
The Michael J. Fox Foundation for Parkinson's Research (MJFF) and the Tau Consortium announced a funding partnership to...
Netherlands Cancer Institute Exploring Molecular Imaging Technology for Prostate Cancer Surgery
News | Molecular Imaging | October 26, 2017
The Netherlands Cancer Institute (NKI) announced it has received funding from the Dutch Cancer Society (KWF...
SNMMI Publishes New FDG PET/CT Appropriate Use Criteria
News | PET-CT | October 25, 2017
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has published appropriate use criteria (AUC) for FDG PET/...
Biodex Unveils Atomlab 500 Dose Calibrator and Wipe Test Counter
Technology | Nuclear Imaging | October 19, 2017
Biodex Medical Systems announced the full release of the Atomlab Dose Calibrator and Wipe Test Counter to the market...
Cleveland Clinic Researchers Reveal Biomarker for Guiding Prostate Cancer Treatment
News | Prostate Cancer | October 17, 2017
October 17, 2017 — Back-to-back discoveries from Cleveland Clinic demonstrate for the first time how a testosterone-r
Overlay Init