News | Radiation Therapy | November 02, 2021

DCISionRT and its Response Subtype Identifies DCIS Patients with Unacceptably Elevated Risk of Local Recurrence after Breast Conserving Surgery and Radiation Therapy

Data presented demonstrates use of DCISionRT and its response subtype (Rst) was able to identify women with ductal carcinoma in situ (DCIS)  (Stage 0 breast cancer) who remain at an elevated risk of recurrence despite receiving breast conserving surgery (BCS) and radiation therapy (RT).

November 2, 2021 — Prelude Corporation, a leader in molecular diagnostics and precision medicine for early-stage breast cancer, presented data in an oral scientific session presentation at the American Society for Radiation Oncology (ASTRO) 63rd Annual Meeting held Oct.24 – 27, 2021, at McCormick Place West in Chicago, IL. Data presented demonstrates use of DCISionRT and its response subtype (Rst) was able to identify women with ductal carcinoma in situ (DCIS) (Stage 0 breast cancer) who remain at an elevated risk of recurrence despite receiving breast conserving surgery (BCS) and radiation therapy (RT).

ASTRO Presentation #513, titled Biosignatures to Optimize Adjuvant Radiation Therapy Use in Patients with DCIS with High Risk Clinicopathologic Features examined 485 women diagnosed with DCIS and treated with BCS, with or without RT. The study examined the utility of DCISionRT and its response subtype by classifying these women into three risk groups:  Low Risk—those who could safely omit RT, Elevated Risk with Good Rst—those who benefited significantly from RT, and Elevated Risk with Poor Rst—those with increased recurrence rates post-treatment with BCS and RT who may need alternative therapeutic strategies beyond standard treatment.

“Women classified into the Elevated Risk group with Good Rst by DCISionRT had significant benefit from adjuvant radiation, with 10-year risk reduced to 5%,” said Frank Vicini, M.D., Radiation Oncologist at GenesisCare, member of NRG Oncology, and presenter of the study. “However, patients classified into the Elevated Risk group with a Poor Rst had a 25% risk of recurrence at 10 years despite being treated with both BCS and adjuvant RT.”

“For the first time, this study demonstrates the ability to identify patients who have high recurrence risk after BCS and RT,” said study investigator Chirag Shah, M.D., Director of Breast Radiation Oncology, Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. “This additional information is critical and will help guide treatment decisions, since Elevated Risk with Poor Rst patients may benefit from supplemental therapeutic strategies.”

“Our ongoing clinical studies reinforce the medical need for personalized treatment decisions for women upon a DCIS diagnosis,” says Dan Forche, President and CEO of PreludeDx.  “Our widely accessible DCISionRT test gives physicians and their patients the utmost confidence in their DCIS treatment decisions. As we continue the development of our precision testing pipeline, including our response subtype biosignature, we look forward to delivering predictive  tools that positively impact treatment decisions and provide peace of mind to even more patients with early-stage breast cancer.”

For more information: www.preludedx.com


Related Content

News | Radiation Oncology

September 26, 2022 — Cleveland Clinic received a $7.9 million five-year grant from the National Cancer Institute at the ...

Time September 26, 2022
arrow
News | Prostate Cancer

September 26, 2022 — Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine’s Game ...

Time September 26, 2022
arrow
News | Breast Imaging

September 26, 2022 — The U.S. Food and Drug Administration (FDA) has granted QT Imaging, Inc. 510(K) clearance to ...

Time September 26, 2022
arrow
News | Breast Density

September 22, 2022 — DenseBreast-info.org (DB-i) announced that it will host the inaugural #WorldDenseBreastDay on ...

Time September 22, 2022
arrow
News | Ultrasound Women's Health

September 21, 2022 — Butterfly Network, Inc. (NYSE: BFLY), a digital health company transforming care through the power ...

Time September 21, 2022
arrow
Feature | Breast Imaging | By Christine Book

Findings from a clinical trial that used artificial intelligence (AI) in an effort to reduce false positives on breast ...

Time September 21, 2022
arrow
News | Women's Health

September 20, 2022 — Scientists from The Tisch Cancer Institute have uncovered a mechanism by which certain breast ...

Time September 20, 2022
arrow
News | Radiation Therapy

September 20, 2022 — UC San Diego Health is the first hospital system in San Diego to offer a new, highly targeted and ...

Time September 20, 2022
arrow
News | MRI Breast

September 16, 2022 — According to ARRS’ American Journal of Roentgenology (AJR), the contrast-enhanced in-phase Dixon ...

Time September 16, 2022
arrow
Feature | Lung Imaging | By Christine Book

“Lung cancer is the deadliest cancer in men and in women, and it all boils down to how it is detected and when it is ...

Time September 16, 2022
arrow
Subscribe Now