News | September 28, 2008

Philips Uses Ultrasound-Activated Microbubbles for Cancer Treatments

September 29, 2008 - Philips is developing a system that uses ultrasound-activated microbubbles for chemotherapy drug delivery designed to increase the effectiveness and reduce the side effects.

The system proposes the use of drug-loaded microbubbles, no larger than red blood cells, which can be injected into the patient’s bloodstream, tracked via ultrasound imaging and then ruptured by a focused ultrasound pulse to release their drug payload when they reach the desired spot. Because the drugs would only be released at the site of the diseased tissue, the patient’s total body exposure to them could be limited. For certain types of treatment – for example, chemotherapy for breast cancer – this could help to reduce unpleasant side effects.

The use of microbubbles in conjunction with medical ultrasound imaging is not new. However, at the moment in clinical practice, microbubbles are only used as contrast agents for example to highlight blood in the ultrasound images – an application that relies on the fact that microbubbles reflect ultrasound much better than blood or soft tissue.

The drug delivery technology being developed by scientists at Philips Research continues to utilize the contrast-enhancing capabilities of microbubbles to help ultrasound operators to locate tumors – based on their density and the fact that tumors typically grow a recognizable network of small blood vessels around themselves. What’s new is that it then shatters the shells of the microbubbles in these blood vessels using a focused high-energy ultrasound pulse. As a result, the drugs contained in the microbubbles are released directly inside the tumor.

Philips is working with several academic partners, including the University of Virginia (USA) and the University of Muenster (Germany), to refine the technology. Clinical institutions, such as The Methodist Hospital in Houston (USA), are also actively researching this new and exciting field of ultrasound mediated drug delivery.

“More and more, patients are demanding treatment options that allow them to maintain their quality of life during the treatment regime, without sacrificing treatment efficacy,” comments King Li, MD, chair of the Department of Radiology at the Methodist Hospital in Houston (USA) and professor of Radiology, Weill Cornell Medical College (USA). ”The non-invasive nature of ultrasound mediated delivery is a step in this direction. Work at our and other institutions using ultrasound for drug delivery and treatment guidance has shown the potential of this technology in pre-clinical studies.”

For more information: www.medical.philips.com

Related Content

Siemens Healthineers Showcases New In Vivo and In Vitro Cardiovascular Solutions at TCT 2018
News | Ultrasound Imaging | September 21, 2018
At the 2018 Transcatheter Cardiovascular Therapeutics (TCT) conference, Sept. 21-25 in San Diego, Siemens Healthineers...
Philips Showcases Integrated Solutions for Cardiovascular Care at TCT 2018
News | Cardiac Imaging | September 20, 2018
At the Transcatheter Cardiovascular Therapeutics (TCT) annual meeting, Sept. 21–25 in San Diego, Philips is showcasing...
Siemens Healthineers Announces First Installation of Acuson Sequoia Ultrasound
News | Ultrasound Imaging | September 20, 2018
September 20, 2018 — Siemens Healthineers announced the first global installation of its newest...
LVivo EF Cardiac Tool Now Available for GE Vscan Extend Handheld Mobile Ultrasound
Technology | Cardiovascular Ultrasound | September 19, 2018
DiA Imaging Analysis Ltd. (DiA), a provider of artificial intelligence (AI)-powered ultrasound analysis tools,...
Exact Imaging Partners to Improve Prostate Cancer Detection With Artificial Intelligence
News | Prostate Cancer | September 19, 2018
Exact Imaging, makers of the ExactVu micro-ultrasound platform, has partnered with U.K.-based Cambridge Consultants to...
Acuson Sequoia
News | Ultrasound Imaging | September 12, 2018
Siemens Healthineers announced the first global installation of its newest ultrasound system, the...
Mount Sinai Serves as Official Medical Services Provider for 2018 U.S. Open
News | Orthopedic Imaging | September 06, 2018
For the sixth consecutive year, Mount Sinai will serve as the official medical services provider for the 2018 U.S. Open...
Konica Minolta Provides Sonimage HS1 Ultrasound for AAPM&R Hands-on Learning Course
News | Ultrasound Imaging | September 05, 2018
Konica Minolta Healthcare Americas recently provided ultrasound systems for The American Academy for Physical Medicine...
Philips Launches Epiq CVx and CVxi Cardiovascular Ultrasound Systems
Technology | Cardiovascular Ultrasound | August 22, 2018
Philips recently announced the introduction of the Epiq CVx cardiovascular ultrasound system. Built on the Epiq...
Fujifilm SonoSite Unveils Full Suite of iViz Point-of-Care Transducers

The L25v ultrasound transducer for the Fujifilm Sonosite iViz is available for superficial applications such as ophthalmic, arterial, venous, lung and nerve. Image courtesy of Fujifilm Sonosite.

Technology | Ultrasound Imaging | August 15, 2018
Fujifilm SonoSite Inc. announced the launch of two new transducers for the SonoSite iViz point-of-care ultrasound, now...