News | September 23, 2009

Philips, Celsion Advance MR-Guided HIFU, Thermodox Therapy Development

September 23, 2009 - Royal Philips Electronics and Celsion Corp. reported on a joint research program to evaluate ThermoDox, Celsion’s heat-activated liposomal drug, in combination with magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) as a combination therapy to non-invasively treat difficult cancers has successfully completed the feasibility stage. The program has now moved into pre-clinical development and will focus on the combined use of ThermoDox and Philips’ MR-HIFU system for the treatment of pancreatic cancer and cancer metastases in bone.

Philips’ MR-HIFU system has the potential to precisely and non-invasively target lesions with acoustic energy, creating sufficient heat to activate ThermoDox and preferentially release high concentrations of the chemotherapy drug doxorubicin. This Celsion-Philips combinational treatment approach may change the paradigm for addressing a broad range of cancers.

Prominent experts in the field of MR-HIFU cancer treatment, including Dr. Bradford Wood of the National Institutes of Health Clinical Center, Dr. Chrit Moonen of the CNRS/University Victor Segalen Bordeaux and Dr. Kullervo Hynynen of Sunnybrook Health Sciences Centre, are participating in the Celsion-Philips research program. Under the leadership of Dr. Wood, these researchers will be conducting pre-clinical studies to assess doxorubicin drug delivery and to optimize MR-HIFU performance in this application. An Investigational New Drug (IND) submission is planned for early 2010, following successful completion of the pre-clinical studies.

The companies’ joint research is focused on the treatment of pancreatic cancer and cancer metastases in bone.

Pancreatic cancer is an aggressive cancer with an extremely high mortality rate. There are 37,000 annual incidences in the U.S, which ranks pancreatic cancer as the fourth leading cause of cancer deaths. Curative surgical resection (also known as the ‘Whipple’ procedure) is indicated in fewer than 20 percent of patients, while chemotherapeutic approaches provide modest, if any, patient survival benefit. These factors illustrate the high unmet need for better treatments and the potential significance of MR-HIFU’s mediated, targeted delivery of doxorubicin.

For bone metastases, ThermoDox combined with MR-HIFU will be investigated both for tumor control as well as for palliative pain treatment. Cancer progresses to bone metastases in a majority of patients with late-stage breast, prostate or lung cancer, with estimates of between 300,000 – 500,000 cases annually in the U.S. Patients typically experience excruciating and unrelenting pain, often treated with opiate drugs and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) with modest benefit. External beam radiation therapy has been used for tumor control, but does not provide significant pain relief for many patients.

Related Content

Philips Introduces Technology Maximizer Program for Imaging Equipment Upgrades
Technology | Imaging | January 17, 2018
January 17, 2018 — Philips recently announced the launch of Technology Maximizer, a cross-modality program designed t
New Vascular Ultrasound Registry Looks to Enhance Patient Care
News | Cardiovascular Ultrasound | January 17, 2018
The Society for Vascular Ultrasound (SVU), the Society for Vascular Surgery (SVS) and Medstreaming-M2S announced the...
Russian Team Developing New Technology to Significantly Reduce MRI Research Costs
News | Magnetic Resonance Imaging (MRI) | January 16, 2018
January 16, 2018 — Researchers from the NUST MISIS Engineering Center for Industrial Technologies in Russia have deve
Smartphone Addiction Creates Imbalance in Brain
News | Mobile Devices | January 11, 2018
Researchers have found an imbalance in the brain chemistry of young people addicted to smartphones and the internet,...
Emergency Radiologists See Inner Toll of Opioid Use Disorders

Rates of Imaging Positivity for IV-SUDs Complications. Image courtesy of Efren J. Flores, M.D.

News | Clinical Study | January 11, 2018
January 11, 2018 – Emergency radiologists are seeing a high prevalence of patients with complications related to opio
Sponsored Content | Videos | Ultrasound Imaging | January 11, 2018
Mindray recently featured a new upgrade for its premium Resona 7 ultrasound system at the Radiological Society of North...
Study Finds No Evidence that Gadolinium Causes Neurologic Harm

MR images through, A, C, E, basal ganglia and, B, D, F, posterior fossa at level of dentate nucleus. Images are shown for, A, B, control group patient 4, and the, C, D, first and, E, F, last examinations performed in contrast group patient 13. Regions of interest used in quantification of signal intensity are shown as dashed lines for globus pallidus (green), thalamus (blue), dentate nucleus (yellow), and pons (red).

News | Contrast Media | January 11, 2018
January 11, 2018 — There is no evidence that accumulation in the brain of the element gadolinium speeds cognitive dec
Weight Loss Through Exercise Alone Does Not Protect Knees
News | Orthopedic Imaging | January 11, 2018
January 11, 2018 – Obese people who lose a substantial amount of weight can significantly slow down the degeneration
Neurofeedback Shows Promise in Treating Tinnitus

The standard approach to fMRI neurofeedback. Image courtesy of Matthew Sherwood, Ph.D.

News | Magnetic Resonance Imaging (MRI) | January 11, 2018
January 11, 2018 — Researchers using...
Overlay Init