News | August 20, 2014

NorthStar Medical Radioisotopes Signs Letter of Intent With GE Healthcare

Relationship will help create a reliable domestic source of vital radioisotope produced without the use of highly enriched uranium

August 20, 2014 — NorthStar Medical Radioisotopes LLC signed a non-exclusive letter of intent with GE Healthcare, a division of General Electric Co., marking further progress toward establishing the first existing commercially viable domestic source of the radioisotope 99molybdenum (99Mo).

99Mo is the parent isotope of 99mtechnetium (99mTc), the most widely used radioisotope in medical diagnostic imaging. Under the purchase agreement, NorthStar will supply GE Healthcare with 99Mo to produce 99mTc for compounding and distribution once its non-uranium-based 99Mo production technology and proprietary RadioGenix isotope separation system have been approved by the U.S. Food and Drug Administration (FDA) and are commercially available.

NorthStar recently signed a similar agreement with the radiopharmacy chain Triad Isotopes Inc.

NorthStar, based in Madison, Wis., is developing a domestic source of 99Mo to help alleviate chronic shortages. The 99Mo will be produced without the use of weapons-useable highly enriched uranium (HEU), helping meet goals set by the U.S. Department of Energy’s (DOE) Global Threat Reduction Initiative (GTRI). The initiative was established to reduce and protect vulnerable nuclear and radiological material located at civilian sites worldwide and to minimize the use of HEU in civilian applications.

99mTc is used in more than 13 million nuclear medicine procedures annually in the United States alone. Key applications include myocardial perfusion imaging (testing how well blood flows through the heart), sentinel node mapping (detecting whether breast cancer cells have spread to the sentinel lymph nodes), hepatobiliary imaging (evaluating the liver, gallbladder and ducts that are part of the biliary system) and inflammation and infection imaging.

Currently, nearly all 99Mo is produced using weapons-useable HEU at aging facilities located outside of the United States, leading to product shortages and creating safety and national security concerns. DOE, through GTRI, works with commercial entities to accelerate the establishment of domestic sources of 99Mo produced without HEU.

NorthStar has two methods of producing non-HEU 99Mo, both of which generate only a benign waste stream. The non-HEU 99Mo produced by NorthStar is for use in the company’s intelligent isotope separation system, the RadioGenix, the first true technological breakthrough in 99Mo/99mTc systems in nearly 45 years.

NorthStar President and Chief Executive Officer George P. Messina said, “Together, NorthStar and GE Healthcare will help ensure that health care professionals have reliable access to the 99mTc isotope they need to give their patients accurate diagnoses and conduct important research. And because the 99Mo parent radioisotope will be produced without the use of highly enriched uranium, we will be helping the United States achieve vital national security and safety goals.”

GE Healthcare Global Product Leader Julie Woodland said, “Continuity of supply of 99Mo to meet the growing demand for diagnostic procedures is a key focus for GE Healthcare. The company is actively working with new alternative 99mTc sources to help ensure that access to the radioisotope is readily available to aid in the diagnosis of patients both today and in the future.”

Read the 2017 article "FDA Clears Path for First Domestic Supply of Tc-99m Isotope." 

For more information: gehealthcare.com, www.northstarnm.com

Related Content

Spectrum Dynamics Sues GE for Theft, Misappropriation of Trade Secrets and Unfair Competition
News | SPECT Imaging | December 06, 2018
Single-photon emission computed tomography (SPECT) cardiac imaging company Spectrum Dynamics filed a lawsuit Dec. 6,...
Subtle Medical Receives FDA Clearance, CE Mark for SubtlePET
Technology | PET Imaging | December 05, 2018
Subtle Medical announced 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market SubtlePET. Subtle...
Mirada Medical Joins U.K. Consortium Exploring Healthcare AI
News | Artificial Intelligence | December 04, 2018
Mirada Medical, a leading global brand in medical imaging software, will form part of an artificial intelligence (AI)...
GE Healthcare Recalls Millennium Nuclear Medicine Systems
News | Nuclear Imaging | November 15, 2018
GE Healthcare announced it is recalling its Millennium Nuclear Medicine Systems due to an incident in which the the top...
Artificial Intelligence Predicts Alzheimer's Years Before Diagnosis
News | Neuro Imaging | November 14, 2018
Artificial intelligence (AI) technology improves the ability of brain imaging to predict Alzheimer’s disease, according...
Researchers Awarded 2018 Canon Medical Systems USA/RSNA Research Grants
News | Radiology Imaging | November 13, 2018
The Radiological Society of North America (RSNA) Research & Education (R&E) Foundation recently announced the...
Subtle Medical Showcases Artificial Intelligence for PET, MRI Scans at RSNA 2018
News | Artificial Intelligence | November 13, 2018
At the 2018 Radiological Society of North America annual meeting (RSNA 2018), Nov. 25-30 in Chicago, Subtle Medical...
University of Missouri Research Reactor First U.S. I-131 Supplier in 30 Years

MURR is the only supplier of I 131 in the United States and the first U.S. supplier since the 1980s. Image courtesy of University of Missouri

News | Radiopharmaceuticals and Tracers | November 13, 2018
The University of Missouri Research Reactor (MURR) recently shipped its first batch of Iodine-131 (I-131), a...
MEDraysintell Projects Increasing Mergers and Acquisitions in Nuclear Medicine
News | Nuclear Imaging | November 07, 2018
With the recent announcement by Novartis to acquire Endocyte , interest from the conventional pharmaceutical industry...
A PET/CT head and neck cancer scan.

A PET/CT head and neck cancer scan.

Feature | Nuclear Imaging | November 05, 2018 | By Sabyasachi Ghosh
“Experimental validation implemented in real-life situations and not theoretical claims exaggerating small advantages