News | Magnetic Resonance Imaging (MRI) | July 25, 2022

Combined MRI/neuromodulation/drug delivery system could revolutionize mental health and neurological therapy 

Gwangju Institute of Science and Technology researchers improve the scanning capability of magnetic particle imaging systems used for medical imaging.

July 25, 2022 —  For any drug to be successful in treating mental health or neurological problems, the medicine has to penetrate the blood-brain barrier (BBB). The BBB is caused by tight openings in the microscopic vessels of the brain which prevent harmful substances from entering the brain, but also keep most useful drugs out. For example, only 0.01% of the anti-Alzheimer therapeutic antibodies in plasma enter the brain.  Of those few drugs that can enter the brain, many cause affect unwanted targets to cause side effects (for example, dyskinesias or weight gain). In results published in the journal Pharmaceutics (https://www.mdpi.com/1999-4923/14/7/1503), Weinberg Medical Physics (WMP) has demonstrated the ability to open the blood-brain-barrier (BBB) in mice and to safely deliver drugs using pulsed magnetic fields with tailored waveforms.  This work, performed in collaboration with Georgetown University, spurs development of a new class of noninvasive image-guided devices capable of safely treating many mental health and neurological disorders. 

Funded by the National Institute for Aging grant aimed at curing Alzheimer disease, the authors demonstrated that a new type of MRI composed of electro-permanent magnets could be used to generate tailored electromagnetic waveforms, some of which were much more effective at opening the BBB than others. As in a CT scanner, the selective electromagnetic waveforms could be applied from multiple sources to focally deliver drugs to specific regions of the brain.  The same device could also use magnetic pulses to help regrow neurons (“plasticity”), as is being done with transcranial magnetic stimulation (TMS). According to Dr. Irving Weinberg, President of WMP, “This new device would allow psychiatrists and neurologists to treat diseased or underdeveloped brain tracts without causing unwanted side effects. Potential disorders to be treated could include addiction, autism, depression, neuropathic pain, and Alzheimer and Parkinson diseases.”  

Using an office-based human-sized version of this non-invasive device, it may prove possible to cure Alzheimer’s by delivering drugs and genes to specified tracts in the brain under real-time imaging guidance. 

For more information: https://www.weinbergmedicalphysics.com/ 

Related Content

News | Teleradiology

August 17, 2022 — In a study published today in the Journal of General Internal Medicine, researchers at the Icahn ...

Time August 17, 2022
arrow
News | X-Ray

August 17, 2022 — The Institute of Human Virology in Nigeria (IHVN) has announced their partnership with Fujifilm, the ...

Time August 17, 2022
arrow
News | Prostate Cancer

August 16, 2022 — A new study published by University of Kentucky Markey Cancer Center researchers suggests that the ...

Time August 16, 2022
arrow
Feature | Radiology Business | By Melinda Taschetta-Millane

Did you know that Imaging Technology News (ITN) maintains more than 40 comparison charts of product specifications from ...

Time August 12, 2022
arrow
News | Radiology Education

August 11, 2022 — After a three-year break, this spring featured the return of the anticipated Canon Roadshow Events ...

Time August 11, 2022
arrow
News | Computed Tomography (CT)

August 11, 2022 — For the first time, researchers successfully captured CT images of an entire woolly mammoth tusk ...

Time August 11, 2022
arrow
News | Radiology Imaging

August 11, 2022 — Bracco Imaging S.p.A. has announced the renewal of the “Bracco Fellowships” initiative, in partnership ...

Time August 11, 2022
arrow
News | Ultrasound Imaging

August 10, 2022 — Butterfly Network, Inc., a digital health company transforming care with handheld, whole-body ...

Time August 10, 2022
arrow
News | Point-of-Care Ultrasound (POCUS)

August 10, 2022 — Mindray North America, a global leader and developer of healthcare technologies and solutions for ...

Time August 10, 2022
arrow
Feature | Magnetic Resonance Imaging (MRI) | Christine Book

August 10, 2022 — The imaging community has lost a legend, recognized for having revolutionized the field of diagnostic ...

Time August 10, 2022
arrow
Subscribe Now