Technology | October 16, 2009

NeuroPak Deep Brain Imaging System Visualizes the Conscious Mind

VisualSonics Inc. introduced the NeuroPak Deep Brain Imaging System, a novel technology that provides pre-clinical neurology researchers with the capability to image biological and cellular processes in the brains of conscious animals.

It works with the Cellvizio LAB Imaging System, a miniature endoscopic fluorescence microscope, to allow users to repeatedly image a section of a small animal's brain, in real time while the animal is awake and moving freely.

While existing research tools limit access to near-surface imaging on sedated animals, Neuropak Imaging System allows researchers real time access to tissue, deep in the brain of a conscious animal, enabling researchers to determine how the brain reacts to different stimuli in real time.

The NeuroPak System uses a small implant in the skull of the mouse, placed over the area of interest in the brain, which allows repeated, reproducible insertion of the probe for imaging sessions which can be hours in duration. The CerboFlex Probe is a special fiber bundle probe designed to fit the implant that is very flexible and lightweight, thus the mouse is free to move around while the fiber probe is in place. The CellVizio LAB is capable of high resolution, real time imaging of fluorescent tissues, cells and markers at micron levels. Based on a robust, patented confocal technology which employs a high resolution fiber bundle, laser scanning unit and sensitive detector optics, the easy-to-use platform allows real-time imaging of microscopic biology inside a living animal.

"NeuroPak(TM) is the first commercially available means to simultaneously image and correlate cellular events in the intact central nervous system with the behavioral responses of laboratory mice," said David Bates, an Application Scientist at VisualSonics. "This imaging technology will enable groundbreaking research in a myriad of neurological disorders such as Alzheimer's, epilepsy and addiction."

The technique was developed as part of a research collaboration between scientists at Mauna Kea Technologies and the Institut Pasteur in Paris. VisualSonics is the exclusive global distributor for Mauna Kea Technologies pre-clinical imaging technologies, including the Cellvizio LAB In Vivo Fiberoptic Fluorescence Microscope, the NeuroPak Deep Brain Imaging System and the CerboFlex Deep Brain Imaging Probe.

For more information: www.visualsonics.com

Related Content

Researchers Awarded 2018 Canon Medical Systems USA/RSNA Research Grants
News | Radiology Imaging | November 13, 2018
The Radiological Society of North America (RSNA) Research & Education (R&E) Foundation recently announced the...
Charles Ananian, M.D.

Charles Ananian, M.D.

Sponsored Content | Case Study | Digital Radiography (DR) | November 07, 2018
Whether it’s a premature baby or a critically ill child, treating little patients is a huge responsibility.
Results of the vertebrae-based analysis (383 vertebrae in 34 patients) for detection of BME.

Results of the vertebrae-based analysis (383 vertebrae in 34 patients) for detection of BME.

Sponsored Content | Case Study | Computed Tomography (CT) | November 06, 2018
The following is a summary of a study published in the
An example of the newest generation of smart cardiac CT software that automatically identifies the anatomy, autotraces the centerlines on the entire coronary tree and labels each vessel segment.

An example of the newest generation of smart cardiac CT software that automatically identifies the anatomy, autotraces the centerlines on the entire coronary tree and labels each vessel segment. This greatly speeds CT workflows, saving time for techs, radiologists and cardiologists.

Feature | Radiology Imaging | October 04, 2018 | By Dave Fornell
Here is a checklist of dose-sparing practices for cardiac computed tomography (CT) imaging used in the cath lab.
Philips Launches Ingenia Ambition X 1.5T MR
News | Magnetic Resonance Imaging (MRI) | September 14, 2018
September 14, 2018 — Philips announced the launch of the Ingenia Ambition X 1.5T...
Videos | Radiation Therapy | September 07, 2018
A discussion with Ehsan Samei, Ph.D., DABR, FAAPM, FSPIE, director of the Duke University Clinical Imaging Physics Gr
Videos | Radiomics | August 09, 2018
A discussion with Martin Vallieres, Ph.D., post-doctoral fellow at McGill University, Montreal, Canada.
Gary D. Luker Named Editor of Radiology: Imaging Cancer

Image courtesy of University of Michigan Medical School

News | Oncology Diagnostics | August 06, 2018
The Board of Directors of the Radiological Society of North America (RSNA) announced that Gary D. Luker, M.D., will...
Videos | Digital Radiography (DR) | August 03, 2018
Sheila Sferrella, president of Regents Health Resources and Bill Finerfrock, president of Capitol Associates, discuss
Videos | AAPM | August 03, 2018
Ehsan Samei, Ph.D., DABR, FAAPM, FSPIE, director of the Duke Un...