Technology | October 16, 2009

NeuroPak Deep Brain Imaging System Visualizes the Conscious Mind

VisualSonics Inc. introduced the NeuroPak Deep Brain Imaging System, a novel technology that provides pre-clinical neurology researchers with the capability to image biological and cellular processes in the brains of conscious animals.

It works with the Cellvizio LAB Imaging System, a miniature endoscopic fluorescence microscope, to allow users to repeatedly image a section of a small animal's brain, in real time while the animal is awake and moving freely.

While existing research tools limit access to near-surface imaging on sedated animals, Neuropak Imaging System allows researchers real time access to tissue, deep in the brain of a conscious animal, enabling researchers to determine how the brain reacts to different stimuli in real time.

The NeuroPak System uses a small implant in the skull of the mouse, placed over the area of interest in the brain, which allows repeated, reproducible insertion of the probe for imaging sessions which can be hours in duration. The CerboFlex Probe is a special fiber bundle probe designed to fit the implant that is very flexible and lightweight, thus the mouse is free to move around while the fiber probe is in place. The CellVizio LAB is capable of high resolution, real time imaging of fluorescent tissues, cells and markers at micron levels. Based on a robust, patented confocal technology which employs a high resolution fiber bundle, laser scanning unit and sensitive detector optics, the easy-to-use platform allows real-time imaging of microscopic biology inside a living animal.

"NeuroPak(TM) is the first commercially available means to simultaneously image and correlate cellular events in the intact central nervous system with the behavioral responses of laboratory mice," said David Bates, an Application Scientist at VisualSonics. "This imaging technology will enable groundbreaking research in a myriad of neurological disorders such as Alzheimer's, epilepsy and addiction."

The technique was developed as part of a research collaboration between scientists at Mauna Kea Technologies and the Institut Pasteur in Paris. VisualSonics is the exclusive global distributor for Mauna Kea Technologies pre-clinical imaging technologies, including the Cellvizio LAB In Vivo Fiberoptic Fluorescence Microscope, the NeuroPak Deep Brain Imaging System and the CerboFlex Deep Brain Imaging Probe.

For more information: www.visualsonics.com

Related Content

American College of Radiology Releases New Patient-Oriented Appropriateness Criteria Summaries
News | Patient Engagement | January 19, 2018
January 19, 2018 — New Appropriateness Criteria (AC) Patient Summaries from the American College of Radiology (ACR) c
National Clinical Decision Support Company (NDSC) has an exclusive deal with the American College of Radiology (ACR) to provide medical imaging appropriate use criteria (AUC).

National Clinical Decision Support Company (NDSC) has an exclusive deal with the American College of Radiology (ACR) to provide medical imaging appropriate use criteria (AUC). 

Feature | Clinical Decision Support | January 18, 2018
January 18, 2018 — Change Healthcare announced the acquisition of National Decision Support Company (NDSC), a leader
Philips Introduces Technology Maximizer Program for Imaging Equipment Upgrades
Technology | Imaging | January 17, 2018
January 17, 2018 — Philips recently announced the launch of Technology Maximizer, a cross-modality program designed t
RSNA 2017 Celebrates Innovation in Radiology
News | Imaging | January 15, 2018
January 15, 2018 — The Radiological Society of North America’s...

Size comparison between 3-D printed prosthesis implant and a penny.

News | 3-D Printing | January 11, 2018
January 11, 2018 — Researchers using...
RSNA 2017 technical exhibits, expo floor, showing new radiology technology advances.
Feature | RSNA 2017 | January 11, 2018
January 11, 2018 — Here is a list of some of the key clinical study presentations, articles on trends and videos from
The artificial intelligence (AI) smart algorithm onboard the Infervision stroke product calculates the volume of bleed on the basis of multiple brain CT slices.

The AI smart algorithm onboard the Infervision stroke product calculates the volume of bleed on the basis of multiple brain CT slices. The size of the bleed volume indicates the urgency and type of treatment required.

Feature | Artificial Intelligence | January 10, 2018 | Greg Freiherr
Exhibitors at the 2017 Radiological Society of North American (RSNA) meeting rode the...
Upcoming radiology conferences, meetings and events. This photo is from the 2017 RSNA opening session.
News | January 09, 2018
ITN maintains a comprehensive listing of radiology specialty meetings on its website at ...
The new GE Healthcare Air Technology MRI coil design is 60 percent lighter than conventional coils, provides more flexibility and conforms to a patient’s anatomy like a blanket. The technology was unveiled at RSNA 2017 in late November.

The new GE Healthcare Air Technology MRI coil design is 60 percent lighter than conventional coils, provides more flexibility and conforms to a patient’s anatomy like a blanket. The technology was unveiled at RSNA 2017 in late November.

Feature | January 08, 2018 | Dave Fornell
Here is the list of the most popular articles and videos on the Imaging Technology News (ITN) magazine website from t
WEBINAR: Neuroimaging from a Clinical MRI Perspective, sponsored by Philips Healthcare. How to better manage your MRI department.
Webinar | Magnetic Resonance Imaging (MRI) | January 08, 2018
The CME credit webinar "Neuroimaging from a Clinical MRI Perspective," will explain how imaging departments can becom
Overlay Init