News | April 27, 2015

MRI Screening Program for Individuals at High Risk of Pancreatic Cancer

MRI screening in Swedish study detects pancreatic lesions in 40 percent of subjects

JAMA Surgery, pancreatic cancer, MRI, screening, high risk

April 27, 2015 — A magnetic resonance imaging (MRI)-based screening program for individuals at high risk of pancreatic cancer identified pancreatic lesions in 40 percent of patients, according to a report published online by JAMA Surgery.

Pancreatic cancer is a leading cause of cancer death and can be considered a global lethal disease because incidence and mortality rates are nearly identical. Although treatment has improved, the surgery rate in patients with ductal adenocarcinoma is around 30 percent and the five-year survival rate is less than 20 percent. In about 10 percent of all patients with pancreatic cancer, it is possible to find a family history, according to the study background.

Marco Del Chiaro, M.D., Ph.D., of the Karolinska Institute, Stockholm, Sweden, and coauthors analyzed short-term results from an MRI-based screening program for patients with a genetic risk of developing pancreatic cancer.

The study included 40 patients (24 women and 16 men with an average age of nearly 50). In 38 of the patients, increased risk of the disease was based on family history of pancreatic cancer. BRCA2, BRCA1 and p16 gene mutations were identified in some patients. The average study follow-up was 12. 9 months, with MRI screening repeated after one year if the initial screen was negative or at six months if there were unspecific findings or findings that did not indicate surgery.

According to the results, MRIs found a pancreatic lesion in 16 patients (40 percent): intraductal papillary mucinous neoplasia, which can become invasive cancer, in 14 patients (35 percent) and pancreatic ductal adenocarcinoma in two patients (5 percent). Five patients (12.5 percent) required surgery (three for pancreatic ductal adenocarcinoma and two for intraductal papillary mucinous neoplasia); the remaining 35 continue under surveillance.

"An MRI-based protocol for the surveillance of individuals at risk for developing pancreatic cancer seems to detect cancer or premalignant lesions with good accuracy. The exclusive use of MRI can reduce costs, increase availability and guarantee the safety of the individuals under surveillance compared with protocols that are based on more aggressive methods. However, because of the small number of patients and the divergent results, this study did not allow evaluation of the efficacy of MRI as a single screening modality," the study concluded.

In a related commentary, Mark S. Talamonti, M.D., of the NorthShore University HealthSystem, Evanston, Ill., wrote: "Pancreatic cancer is diagnosed in only 10 percent of patients with syndromic risk factors or a family history of pancreatic cancer. The other 90 percent are considered sporadic cancers with no currently known risk factors. And that is the real challenge for the future of early detection of pancreatic cancer. In current clinical practice, no biomarkers exist for diagnosing early-stage disease. Population screening with radiographic imaging or endoscopic procedures makes no clinical or economic sense for a cancer that represent only 3 percent of estimated new cancers each year; however, with an aging population, this most formidable of human cancers will only increase in incidence and frequency. There is a clear and unequivocal need for affordable screening strategies based on reliable biomarkers and efficient imaging modalities."

For more information: www.jamanetwork.com

Related Content

Smartphone Addiction Creates Imbalance in Brain
News | Mobile Devices | January 11, 2018
Researchers have found an imbalance in the brain chemistry of young people addicted to smartphones and the internet,...
Emergency Radiologists See Inner Toll of Opioid Use Disorders

Rates of Imaging Positivity for IV-SUDs Complications. Image courtesy of Efren J. Flores, M.D.

News | Clinical Study | January 11, 2018
January 11, 2018 – Emergency radiologists are seeing a high prevalence of patients with complications related to opio
Study Finds No Evidence that Gadolinium Causes Neurologic Harm

MR images through, A, C, E, basal ganglia and, B, D, F, posterior fossa at level of dentate nucleus. Images are shown for, A, B, control group patient 4, and the, C, D, first and, E, F, last examinations performed in contrast group patient 13. Regions of interest used in quantification of signal intensity are shown as dashed lines for globus pallidus (green), thalamus (blue), dentate nucleus (yellow), and pons (red).

News | Contrast Media | January 11, 2018
January 11, 2018 — There is no evidence that accumulation in the brain of the element gadolinium speeds cognitive dec
Weight Loss Through Exercise Alone Does Not Protect Knees
News | Orthopedic Imaging | January 11, 2018
January 11, 2018 – Obese people who lose a substantial amount of weight can significantly slow down the degeneration
Neurofeedback Shows Promise in Treating Tinnitus

The standard approach to fMRI neurofeedback. Image courtesy of Matthew Sherwood, Ph.D.

News | Magnetic Resonance Imaging (MRI) | January 11, 2018
January 11, 2018 — Researchers using...
Male Triathletes May Be Putting Their Heart Health at Risk
News | Cardiac Imaging | January 09, 2018
Competitive male triathletes face a higher risk of a potentially harmful heart condition called myocardial fibrosis,...
State-of-the-Art MRI Technology Bypasses Need for Biopsy
News | Magnetic Resonance Imaging (MRI) | January 09, 2018
January 9, 2018 – The most common type of tumor found in the kidney is generally quite small (less than 1.5 in).
New Studies Show Brain Impact of Youth Football
News | Neuro Imaging | January 09, 2018
School-age football players with a history of concussion and high impact exposure undergo brain changes after one...
The new GE Healthcare Air Technology MRI coil design is 60 percent lighter than conventional coils, provides more flexibility and conforms to a patient’s anatomy like a blanket. The technology was unveiled at RSNA 2017 in late November.

The new GE Healthcare Air Technology MRI coil design is 60 percent lighter than conventional coils, provides more flexibility and conforms to a patient’s anatomy like a blanket. The technology was unveiled at RSNA 2017 in late November.

Feature | January 08, 2018 | Dave Fornell
Here is the list of the most popular articles and videos on the Imaging Technology News (ITN) magazine website from t
WEBINAR: Neuroimaging from a Clinical Perspective, sponsored by Philips Healthcare. How to better manage your MRI department.
Webinar | Magnetic Resonance Imaging (MRI) | January 08, 2018
The CME credit webinar "Neuroimaging from a Clinical Perspective," will explain how imaging departments can become mo
Overlay Init