News | December 04, 2013

MR-Guided Ultrasound Offers Noninvasive Treatment for Breast Cancer

women's health rsna 2013 mri systems radiation therapy ultrasound
December 4, 2013 — A technique that uses focused ultrasound under magnetic resonance (MR) guidance to heat and destroy tumors may offer a safe and effective treatment for breast cancer, according to research being presented today at the Radiological Society of North America Annual Meeting (RSNA 2013).
 
MR-guided focused ultrasound (MRgFUS) ablation is a noninvasive technique that requires no incision or puncture to perform. Instead, it uses the acoustic energy from high-intensity focused ultrasound to remove, or ablate, diseased tissue. Continuous MRI is used to locate the lesions and monitor the temperature change during the ablation process.
 
Primary advantages of MRgFUS over other breast cancer treatments are that it is a noninvasive, outpatient procedure offering a quick recovery time, and that it provides precise measurement of temperature changes during the procedure.
 
"In the treatment stage, we are able to precisely visualize where the energy is having an effect and to measure exactly the rise in temperature," said Alessandro Napoli, M.D., Ph.D., assistant professor of radiology, Sapienza University, Rome. "Temperature monitoring is particularly important, since too low a temperature is ineffective and too high a temperature may be dangerous."
 
Napoli and colleagues assessed the safety and efficacy of MRgFUS in 12 patients with invasive ductal breast cancer before surgical removal of the cancer and biopsy of the lymph nodes. They used 3T MRI to confirm the presence and treatable location of cancerous lesions. The patients then underwent single-session MRgFUS treatment. Researchers evaluated treatment efficacy through post-surgery pathology.
 
None of the patients experienced significant complications during or immediately after the procedure. In 10 of the 12 patients, MRI showed no enhancement in the treatment area after the procedure. Post-surgery histological evaluation confirmed the absence of residual disease in the treatment area in those 10 patients.
 
"This procedure allows for safe ablation of breast cancer," said Napoli. "At pathology, no significant viable tumor was found in the specimens from these 10 patients."
 
In the other two cases, treatment failed due to transducer malfunction, and the pathologist observed residual tumor in the samples.
 
According to Napoli, MRI guidance is crucial for correct identification of lesions, treatment planning and real-time control during the procedure. Specifically, monitoring with MRI allows for efficient deposit of energy into the region of treatment at the correct range of between 60 degrees and 70 degrees Celsius (approximately 140 to 158 degrees Fahrenheit).
 
"This is carried out by a special sequence that is called MR thermometry," said Napoli. "Only MRI presently has the ability to determine, in real time, fine temperature quantification."
 
While the initial results are promising, Napoli said more research will be needed before the approach can be adopted as a stand-alone treatment for breast cancer. 
 
Co-authors are Luisa Di Mare, M.D., Federica Pediconi, M.D., Michele Anzidei, M.D., Vincenzo Noce, M.D., and Carlo Catalano, M.D.
 
For more information: www.rsna.org

Related Content

Sponsored Content | Videos | Radiation Therapy | November 15, 2017
Chris Toth, president, Oncology Systems Americas, takes a tour of Varian’s new product introductions and major initia
Study Unveils Brain Changes During Extended Space Missions
News | Neuro Imaging | November 14, 2017
November 14, 2017 — More people today are poised to explore space than ever before; those who do will experience the
Synthetic CT Images Suitable for Prostate Cancer Radiotherapy Planning
News | Treatment Planning | November 14, 2017
Spectronic Medical announced that new data for their MRIPlanner software, generating synthetic computed tomography (sCT...
Biop Medical Launches Cervical Cancer Diagnosis Technology at MEDICA 2017

Biop Medical cervical cancer detection system

Technology | Women's Health | November 13, 2017
November 13, 2017 — Biop Medical announced it will present its point-of-care...
News | Magnetic Resonance Imaging (MRI) | November 13, 2017
Aspect Imaging announced last week that it received CE marking for the neonatal-dedicated Embrace Neonatal Magnetic...
Hitachi Healthcare Highlights Benefits of High-Field Open MRI in New Supplement

Click here to view the supplement.

News | Magnetic Resonance Imaging (MRI) | November 13, 2017
A new 24-page publication from Hitachi Healthcare details the benefits of High-Field Open MRI and is now available for...
Kansas City Radiology Center Employs iCAD PowerLook Tomo Detection for DBT
News | Computer-Aided Detection Software | November 10, 2017
November 10, 2017 — Imaging for Women, a leading radiology center in Kansas City, Mo., announced it is now using iCAD
Kubtec Brings Image Analytics Capabilities to Tomosynthesis Specimen Imaging Systems
News | Mammography | November 10, 2017
Kubtec announced it will be showcasing new image analytics capabilities on its advanced tomosynthesis specimen imaging...
Siemens Healthineers Introduces Share360 Tailored Service Portfolio
News | Imaging | November 10, 2017
November 10, 2017 — To address the specific needs of...
Johns Hopkins Researchers, Carestream Give Presentations on Medical Imaging Advances at RSNA
News | Digital Radiography (DR) | November 09, 2017
November 9, 2017 — Researchers from The Johns Hopkins University School of Medicine and Carestream Health scientists
Overlay Init