News | December 04, 2013

MR-Guided Ultrasound Offers Noninvasive Treatment for Breast Cancer

women's health rsna 2013 mri systems radiation therapy ultrasound
December 4, 2013 — A technique that uses focused ultrasound under magnetic resonance (MR) guidance to heat and destroy tumors may offer a safe and effective treatment for breast cancer, according to research being presented today at the Radiological Society of North America Annual Meeting (RSNA 2013).
 
MR-guided focused ultrasound (MRgFUS) ablation is a noninvasive technique that requires no incision or puncture to perform. Instead, it uses the acoustic energy from high-intensity focused ultrasound to remove, or ablate, diseased tissue. Continuous MRI is used to locate the lesions and monitor the temperature change during the ablation process.
 
Primary advantages of MRgFUS over other breast cancer treatments are that it is a noninvasive, outpatient procedure offering a quick recovery time, and that it provides precise measurement of temperature changes during the procedure.
 
"In the treatment stage, we are able to precisely visualize where the energy is having an effect and to measure exactly the rise in temperature," said Alessandro Napoli, M.D., Ph.D., assistant professor of radiology, Sapienza University, Rome. "Temperature monitoring is particularly important, since too low a temperature is ineffective and too high a temperature may be dangerous."
 
Napoli and colleagues assessed the safety and efficacy of MRgFUS in 12 patients with invasive ductal breast cancer before surgical removal of the cancer and biopsy of the lymph nodes. They used 3T MRI to confirm the presence and treatable location of cancerous lesions. The patients then underwent single-session MRgFUS treatment. Researchers evaluated treatment efficacy through post-surgery pathology.
 
None of the patients experienced significant complications during or immediately after the procedure. In 10 of the 12 patients, MRI showed no enhancement in the treatment area after the procedure. Post-surgery histological evaluation confirmed the absence of residual disease in the treatment area in those 10 patients.
 
"This procedure allows for safe ablation of breast cancer," said Napoli. "At pathology, no significant viable tumor was found in the specimens from these 10 patients."
 
In the other two cases, treatment failed due to transducer malfunction, and the pathologist observed residual tumor in the samples.
 
According to Napoli, MRI guidance is crucial for correct identification of lesions, treatment planning and real-time control during the procedure. Specifically, monitoring with MRI allows for efficient deposit of energy into the region of treatment at the correct range of between 60 degrees and 70 degrees Celsius (approximately 140 to 158 degrees Fahrenheit).
 
"This is carried out by a special sequence that is called MR thermometry," said Napoli. "Only MRI presently has the ability to determine, in real time, fine temperature quantification."
 
While the initial results are promising, Napoli said more research will be needed before the approach can be adopted as a stand-alone treatment for breast cancer. 
 
Co-authors are Luisa Di Mare, M.D., Federica Pediconi, M.D., Michele Anzidei, M.D., Vincenzo Noce, M.D., and Carlo Catalano, M.D.
 
For more information: www.rsna.org

Related Content

Ingenia Ambition X 1.5T MR. This innovation is the latest advance in the Ingenia MRI portfolio, which comprises fully-digital MRI systems, healthcare informatics and a range of maintenance and life cycle services for integrated solutions that empower a faster, smarter, and simpler path to enabling a confident diagnosis
News | Magnetic Resonance Imaging (MRI) | September 14, 2018
Philips, a global leader in health technology, launched the Ingenia Ambition X 1.5T MR.
breast screening
News | Clinical Trials | September 13, 2018
Fewer and fewer women die from breast cancer in recent years but, surprisingly, the decline is just as large in the a
Amar Kishan, M.D.

Amar Kishan, M.D.

News | Prostate Cancer | September 11, 2018
UCLA researchers have discovered that a combination of high doses of...
Lightvision near-infrared fluorescence imaging system
News | Women's Health | September 11, 2018
Shimadzu Corp.
Veye Chest version 2
News | Lung Cancer | September 11, 2018
Aidence, an Amsterdam-based medical AI company, announced that Veye Chest version 2, a class IIa medical device, has
Videos | Radiation Therapy | September 07, 2018
A discussion with Ehsan Samei, Ph.D., DABR, FAAPM, FSPIE, director of the Duke University Clinical Imaging Physics Gr
Feature | Breast Imaging | September 07, 2018 | By JoAnn Pushkin
If you are confused about the conflicting advice surrounding mammography screening guidelines, welcome to the club.
Boston Scientific to Acquire Augmenix Inc.
News | Patient Positioning Radiation Therapy | September 07, 2018
Boston Scientific has entered into a definitive agreement to acquire Augmenix Inc., a privately-held company which has...
Sponsored Content | Case Study | Magnetic Resonance Imaging (MRI) | September 07, 2018 | By Sabine Sartoretti, M.D.
As soon as the Compressed SENSE technology became available to the MRI team at Kantonsspital Winterthur (Switzerland),...
Overlay Init