News | SPECT-CT | August 24, 2016

Molecular Dynamics' CZT-based Digital SPECT/CT Trial Shows Promising Results

Digital detector-based SPECT/CT prototype displays improved sharpness and contrast compared to analog SPECT

Valiance X12, SPECT/CT, CZT detectors, clinical trial

Tc99m MDP SPECT bone study images of a 35 year old male with right ankle pain. Top: Valiance X12. Bottom: Analog SPECT. Image courtesy of Molecular Dynamics.

August 24, 2016 — Molecular Dynamics has successfully completed the first phase of a clinical trial to evaluate the Valiance X12 whole-body cadmium zinc telluride (CZT)-based digital SPECT/CT prototype with promising results. The study, conducted at the Chaim Sheba Medical Center in Israel, was designed to assess the image quality and diagnostic performance of the Valiance X12 and demonstrated improved image resolution and contrast.

The Valiance X12 was used to acquire digital SPECT (single photon emission computed tomography) scans from 25 patients, who had previously undergone analog SPECT scans, at the Department of Nuclear Medicine under the supervision of Ronen Goldkorn, M.D., and Elinor Goshen, M.D.  

The Valiance X12 digital studies were reviewed by experienced readers and were compared to the analog studies. Images were graded on a scale of 1 (poor) to 4 (very good) for sharpness and contrast. The mean grades for the Valiance X12 digital SPECT images exceeded those of analog SPECT images for sharpness (3.8 vs 3.1) and contrast (3.9 vs 3.3). Furthermore, focused digital SPECT on a specific region of interest was shown to further increase both the sharpness and contrast of the Valiance X12 images.  

"These findings are promising for CZT-based digital SPECT," said Goshen.  "Further research will assess other general nuclear medicine applications, as well as the contribution of focused imaging, a unique capability of the Valiance X12."

The unique architecture of the Valiance X12 includes CZT-based detectors with independent radial swivel motion, gantry rotation and adaptive image acquisition, which focus the detectors on specific regions, providing multiple angular views and enhanced images of a target.

Goshen will present these results along with additional findings at the European Association of Nuclear Medicine Annual Congress, Oct. 15-19 in Barcelona, Spain.

For more information: www.molecular-d.com

Related Content

New Study Redefines Therapeutic Dose Guidelines for Non-Small Cell Lung Cancer
News | Lung Cancer | April 23, 2019
Non-small cell lung cancer is a common cancer for both men and women. Many people who are diagnosed with this type of...
Comparison of state Medicaid fees for radiation oncology services for breast cancer and nonradiation oncology services per the Kaiser Family Foundation Index

Fig. 1: Comparison of state Medicaid fees for radiation oncology services for breast cancer and nonradiation oncology services per the Kaiser Family Foundation Index. (Agarwal et al, Red Journal, 2019) Credit: Elsevier

News | Radiation Therapy | April 22, 2019
April 22, 2019 — A new study finds wide state
Stereotactic Radiosurgery Effective for Pediatric Arteriovenous Malformation Patients
News | Radiation Therapy | April 19, 2019
Ching-Jen Chen, M.D., of the neurosurgery department at the University of Virginia (UVA) Health System, was the winner...
Video Plus Brochure Helps Patients Make Lung Cancer Scan Decision

Image courtesy of the American Thoracic Society

News | Lung Cancer | April 19, 2019
A short video describing the potential benefits and risks of low-dose computed tomography (CT) screening for lung...
Surgically Guided Brachytherapy Improves Outcomes for Intracranial Neoplasms
News | Brachytherapy Systems | April 18, 2019
Peter Nakaji, M.D., FAANS, general practice neurosurgeon at Barrow Neurological Institute, presented new research on...
Check-Cap Initiates U.S. Pilot Study of C-Scan for Colorectal Cancer Screening
News | Colonoscopy Systems | April 15, 2019
Check-Cap Ltd. has initiated its U.S. pilot study of the C-Scan system for prevention of colorectal cancer through...
Deep Lens Closes Series A Financing for Digital AI Pathology Platform
News | Digital Pathology | April 09, 2019
Digital pathology company Deep Lens Inc. announced the closing of a $14 million Series A financing that will further...
Uterine Fibroid Embolization Safer and as Effective as Surgical Treatment
News | Interventional Radiology | April 05, 2019
Uterine fibroid embolization (UFE) effectively treats uterine fibroids with fewer post-procedure complications compared...
News | Biopsy Systems | March 29, 2019
Dune Medical Devices has just completed the first in-man cases for Smart Biopsy, its percutaneous soft tissue biopsy...
Artificial Intelligence Can Improve Emergency X-ray Identification of Pacemakers
News | X-Ray | March 29, 2019
A research team from Imperial College London believes a new software could speed up the diagnosis and treatment of...