News | Radiopharmaceuticals and Tracers | November 03, 2015

Minomic to Begin First-In-Human Trial of Novel Prostate Cancer Imaging Agent

Australian trial with 12 patients to begin in first quarter of 2016

Minomic, MUH, first-in-human trial, novel prostate cancer imaging agent, MIL-38, Australia

November 3, 2015 — Australian immuno-oncology company Minomic International Ltd has struck an agreement to launch the first human study of its novel monoclonal antibody technology as an imaging agent to detect prostate, pancreatic and bladder cancers.

The company has signed a Heads of Agreement with Macquarie University Hospital (MUH) and Macquarie Medical Imaging (MMI) to examine the use of Minomic’s proprietary MIL-38 monoclonal antibody — already a centrepiece of its MiCheck novel prostate cancer diagnostic screening technology — as a new tool to enable better detection and targeted treatment of prostate and other cancers.

This first-in-human study will begin recruiting the first of 12 patients in Q1 2016, with the study expected to run during 2016.

Under study protocols, a team of investigators led by Profs. Howard Gurney and David Gillatt from MUH and Kevin Ho-Shon, Ph.D., of MMI, will examine a chimeric version of Minomic’s MIL-38 antibody conjugated with 67Gallium (MILGa) to image cancer metastases following ethics approval.

Investigators will evaluate the technology for safety, sensitivity and specificity of MILGa in these patients.

“We have had highly encouraging results in our preclinical animal studies. By formulating a chimeric version of the MIL-38 antibody, we are able to ensure a patient’s own immune system does not recognise our antibody as foreign. Our antibody will then seek out the target, which is a protein found on cancer cells. We will attach a payload to our antibody – either an existing drug or radiotherapy – so that our technology can be used to directly deliver the appropriate therapy to the tumour cell target for maximum impact. Following successful targeting to tumour metastases in this study the company intends to undertake a therapeutic trial,” said Minomic CEO Brad Walsh, Ph.D.

For more information: www.minomic.com

Related Content

ProCure Proton Therapy Center New Jersey Celebrates Five-Year Cancer-Free Milestone for Prostate Cancer Patients
News | Proton Therapy | September 20, 2017
ProCure Proton Therapy Center in Somerset, N.J., recently celebrated the five-year cancer-free milestone for the first...
News | Business | September 19, 2017
September 19, 2017 — Invicro LLC, a provider of imaging services and software for research and drug development, anno
ScImage and Invia Partnership Announced
News | PACS | September 19, 2017
ScImage Inc. and Invia Imaging Solutions recently announced formation of a joint partnership at the American Society of...
Toshiba Highlights Latest CT Advancements at RSNA 2017
News | Computed Tomography (CT) | September 18, 2017
Toshiba Medical announced that it will display several new enhancements to its existing computed tomography (CT)...
Philips Launches CardioMD IV Cardiac SPECT Solution at ASNC 2017
Technology | SPECT Imaging | September 15, 2017
September 15, 2017 — Philips highlighted its newest solution for...
Double Targeting Ligands to Identify and Treat Prostate Cancer

The mice were imaged with small-animal PET/CT using 124I-RPS-027 (7.4 MBq [200 μCi]). Credit: JM Kelly et al., Department of Radiology, Weill Cornell Medicine, New York, NY

News | Prostate Cancer | September 14, 2017
Researchers have demonstrated a new, effective way to precisely identify and localize prostate cancer tumors while...
Blue Earth Diagnostics Announcing Results of FALCON PET/CT Trial at ASTRO 2017
News | PET-CT | September 13, 2017
September 13, 2017 — Blue Earth Diagnostics announced the upcoming oral presentation of initial results from the FALC
U.K.'s NICE Supports Use of Hydrogel Spacer in Prostate Cancer Treatement
News | Patient Positioning Radiation Therapy | September 08, 2017
Augmenix Inc. announced that the National Institute for Health and Care Excellence (NICE) in the U.K. has issued...
FDG-PET/CT Predicts Melanoma Patients' Response to Immune Checkpoint Inhibitor Therapy
News | PET-CT | September 07, 2017
September 7, 2017 — Advanced melanoma has a poor prognosis, but immune checkpoint inhibitor therapy can be effective
Overlay Init