Technology | November 02, 2011

Low Dose Molecular Breast Imaging Aids Tumor Detection

Gamma Medica Inc. will demonstrate the LumaGEM Low Dose Molecular Breast Imaging (MBI) System at RSNA 2012. 

LumaGEM MBI is the first commercially available, U.S. Food and Drug Administration (FDA)-cleared, planar, dual-head, fully solid state digital imaging system utilizing cadmium zinc telluride (CZT) technology used for digital breast imaging.  LumaGEM Low Dose MBI is a major advancement in the area of molecular imaging, identifying tumors in dense breast tissue that are often not visible with mammography. 

A 2011 publication in Radiology (doi:10.1148/radiol.10100625), documented the addition of molecular breast imaging (MBI) in 1,000 patients, following an injection of 20 mCi Tc-99m sestamibi, to screening mammography (MG) significantly increased detection of breast cancer in dense breasts from 27 percent with MG alone to 91 percent with the combination (p=0.016).

After implementing modifications that permit further radiation dose reduction, performance has been clinically compared between screen mammography and prevalent screen low-dose MBI in 2,400 women with dense breasts using an 8 mCi injection of Tc-99m sestamibi, dual-head CZT detectors by Gamma Medica, and acquired in dynamic frames to allow the generation of 4 mCi equivalent images.

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