News | Radiopharmaceuticals and Tracers | August 20, 2015

The ITM Group Announces In-Licensing of DOTA-Zoledronate Theranostic Agent

Nuclear tracer indicated for bone targeted radionuclide therapy and diagnostics in patients with bone metastases

The ITM Group, in-licensing, DOTA-Zoledronate, theranostic agent, bone metastases, PET imaging

August 20, 2015 — The ITM Group announced that its subsidiary ITG GmbH has successfully in-licensed DOTA-Zoledronate, a next-generation theranostic agent for bone targeted radionuclide therapy and diagnostics in patients suffering from bone metastases. DOTA-Zoledronate specifically targets cancerous bone lesions and, when radiolabeled with therapeutic or diagnostic radioisotopes, has shown high potential for positron emission tomography (PET) imaging and endoradiotherapy.

In first studies DOTA-Zoledronate showed a high target to background ratio and a fast clearance pathway. Moreover, the novel bone agent is attractive for tagging of various radionuclides like the generator derived PET-radionuclide Gallium-68, therapeutic beta-emitting no-carrier-added (n.c.a) Lutetium-177 as well as the α-particle emitters Actinium-225 and Bismuth-213.

Due to its versatile properties for radiolabeling, DOTA-Zoledronate is a promising agent for the development of other future-oriented radionuclide therapy concepts for personalized nuclear oncology. Fundamental research into radiolabeled DOTA-Zoledronate conjugates has recently been conducted at the Johannes Gutenberg University Mainz led by the head of the Institute of Nuclear Chemistry, Prof. Frank Rösch.

For more information: www.itg-garching.de

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