July 29, 2008 - Most cancer tumors that have clear borders and are well defined have traditionally been treated successfully by surgical removal.

But not all cancers respond to conventional surgery. More importantly, conventional surgery brings risks of complications and long recovery periods that can negatively impact a person's quality of life.

To overcome these treatment limits, a group of researchers based at the University of Texas' M.D. Anderson Cancer Center, turned to lasers and nanotechnology. They explored an emerging minimally-invasive approach to treating tumors that delivers a lethal dose of laser-generated heat to tumors, known as thermal ablation. To improve thermal ablation,they added a nano-twist that precisely guides and concentrates heat in targeted tumors.

Working with Nanospectra Biosciences, Inc., researchers injected nanoshells made of gold silica into canine models of brain cancer. The nanoshells homed to the target tumors, where they were taken in by the tumor cells. Next, researchers irradiated the nanoparticle-filled tumor

with low-power laser light to selectively heat the tumor-but not the surrounding, healthy tissue. M.D. Anderson researchers added iron-oxide cores to the nanoshells to make them visible by magnetic resonance imaging so researchers could observe the process.

Results from these experiments were supported by numerical modeling studies, and by scanning electron microscope data showing destructive thermal increases near the tumors’ blood supplies.

"Based on these encouraging early results, we conclude that the use of magnetic resonance temperature imaging and gold nanoshells hold the very real possibility of meeting the long-sought goal of improving the precision of thermal ablation, while sparing healthy tissue," explains M.D.
Anderson Cancer Center's R.J. Stafford, Ph.D. "Temperature imaging and guidance is an invaluable tool furthering this approach as it moves from feasibility studies to future use in human clinical trials."

For more information: www.aapm.org

Source: American Association of Physicists in Medicine

Related Content

News | Interventional Radiology

Varian announced it has signed an asset purchase agreement to acquire the Boston Scientific portfolio of drug-loadable microsphere and bland embolic bead products for treating arteriovenous malformations and hypervascular tumors. When completed, this acquisition, in combination with the recent acquisitions of Endocare and Alicon, will expand Varian's portfolio of multidisciplinary integrated cancer care solutions.

Time July 03, 2019
arrow
Technology | Focused Ultrasound Therapy

Insightec announced that the U.S. Food and Drug Administration (FDA) has approved an expansion of the indication of Exablate Neuro to include the treatment of patients with tremor-dominant Parkinson's disease (PD).

Time December 21, 2018
arrow
Videos | Radiation Oncology

Genomics can be used to assess a patient's radiosensitivity, which can be used to increase or decrease the radiation ...

Time November 06, 2018
arrow
News | Radiation Dose Management

AngioDynamics Inc. announced an agreement to acquire RadiaDyne, a privately held medical diagnostic and device company that designs and develops patient dose monitoring technology to improve cancer treatment outcomes.

Time September 24, 2018
arrow
News | Radiation Oncology

World Cancer Day takes place annually on Feb. 4 to raise awareness and education in the media, governments and people ...

Time February 01, 2018
arrow
News | Oncology Related Products

December 19, 2016 — Children’s National Health System and Celsion Corp. announced in November the launch of a clinical ...

Time December 19, 2016
arrow
News | Clinical Decision Support

October 27, 2016 — The National Comprehensive Cancer Network (NCCN) continues to build its library of appropriate use ...

Time October 27, 2016
arrow
News | Ultrasound Imaging

September 12, 2016 — Tiny microbubbles are being used to more effectively identify liver tumors, according to a study ...

Time September 12, 2016
arrow
Feature | Cardio-oncology | Dave Fornell

Cardio-oncology is an emerging field that combines the expertise of both cardiology and oncology to assess and treat ...

Time May 13, 2016
arrow
News | Oncology Related Products

May 6, 2016 — After breast cancer surgery, women are prescribed adjuvant (or follow-up) therapies such as chemotherapy ...

Time May 06, 2016
arrow
Subscribe Now