News | August 04, 2011

First Multi-Site Study Evaluates Targeted Radiation Approach for Shorter, Safer Prostate Treatment

August 4, 2011—The first multi-institutional study evaluating a new form of radiation treatment for prostate cancer coupled with sophisticated real-time tumor tracking is now underway at the University of Michigan Health System in Ann Arbor, Mich. Principal investigator Daniel A. Hamstra, Ph.D., M.D., assistant professor, department of radiation oncology, along with 10 co-investigators, are evaluating the safety of shortened (hypofractionated) stereotactic body radiation therapy (SBRT) with Calypso Medical’s GPS for the Body technology, used for real-time tracking of cancerous tumors during prostate radiotherapy, and comparing it to conventional radiation treatment.

According to Hamstra and co-investigators, SBRT heightens the need for accurate, precise real-time tracking of prostate motion during radiation treatment. The delivery of larger, more concentrated radiation doses creates concern about exposing the surrounding healthy tissue to the same high doses, thereby increasing the potential for side effects such as rectal injury, impotence and difficulty urinating. Calypso Medical’s real-time tracking technology accurately and precisely tracks the location of the prostate to allow doctors to confidently deliver larger doses of SBRT, while lowering the total number of treatments.

“To a large extent, identification of prostate location has only been performed prior to the start of treatment without taking into account the motion of the prostate during treatment, yet precise targeting of the prostate gland during radiation is critically important in order to avoid delivering unintended radiation to healthy tissue,” said Hamstra. “This is the first multi-institutional study to incorporate use of the Calypso real-time tumor tracking technology, which allows us to significantly reduce the margin of healthy tissue around the prostate to prevent the development of unwelcome side effects. We are optimistic that use of the Calypso System in concert with a small number of dose-intensified treatment sessions may be a way to optimize SBRT.”

The multi-site study is testing whether a short-course, treatment regimen with continuous real-time evaluation of prostate motion is safe and effective for patients compared to conventional treatment. The 39-month Phase II study will enroll 66 patients, who will receive five 30-minute treatment sessions (fractions) of radiation with at least two days between each fraction. Each fraction size will be 7.4 Gray (unit of absorbed radiation dose) and the total radiation dose will be 37 Gray. The shortened five-fraction treatment will range from just 15-19 calendar days in comparison to conventional treatment protocol of 40-45 daily treatments, which takes eight-to-nine weeks to complete.

“The Calypso technology is critical because it provides the only real-time means to localize the prostate, providing needed information regarding motion that occurs due to normal bladder and bowel filling,” said Dale Litzenberg, Ph.D., co-investigator and clinical assistant professor, department of radiation oncology, University of Michigan. “With this information, we can use tighter treatment margins, which should lessen the risk for both acute and late toxicities. Combining Calypso with SBRT creates a treatment approach that allows patients to maintain their quality of life while spending significantly less time away from family and work.”

In addition to the University of Michigan, participating institutions include Washington University (St. Louis, Mo.); The Fox Chase Cancer Center (Philadelphia); Cedars Sinai Medical Center (Los Angeles), and Radiation Oncology Centers (Sacramento, Calif.).

“We are very encouraged by this multi-institutional study evaluating Calypso’s real-time tumor tracking for prostate SBRT, as this research will offer broad-based information to complement previous single-center studies with the same objectives,” said Lisa Levine, Ph.D., vice president, clinical and pre-market regulatory affairs for Calypso Medical. “Recent results from a single-center study reported favorable toxicity and quality-of-life outcomes in urinary, rectal and sexual function. These study results and others suggest that the much shorter delivery schedule combined with the potential for a more efficacious treatment makes SBRT a very appealing option for the right patient.”

Calypso Medical will highlight the use of real-time tracking during prostate cancer radiotherapy and investigational use in lung cancer at the upcoming 2011 Joint American Association of Physicists in Medicine (AAPM) and the Canadian Organization of medical Physicists (COMP) meeting, July 31-August 4 at the Vancouver Convention Centre (Booth #1131).
 
For more information: www.calypsomedical.com

Related Content

New Method Improves Ability to Measure and Maximize Radiation Therapy Dose
News | Radiation Therapy | May 14, 2019
Delivering just the right dose of radiation for cancer patients is a delicate balance in their treatment regime....
Sponsored Content | Videos | Radiation Oncology | May 13, 2019
At ASTRO 2018, Accuray showcased new patient-fi
Radiotherapy After Chemo May Improve Survival in Advanced Hodgkin's Lymphoma Patients
News | Radiation Therapy | May 10, 2019
Patients with advanced Hodgkin's lymphoma who have large tumors at the time of diagnosis may benefit from radiotherapy...
IBA Partnering to Develop Advanced Digital Proton Therapy Technologies in Belgium
News | Proton Therapy | May 10, 2019
IBA (Ion Beam Applications SA) announced a research agreement with Skandionkliniken, Université Catholique de Louvain...
A CyberHeart cardiac ablation radiotherapy treatment plan showing where the radiation beam will ablate for a noninvasive pulmonary vein isolation procedure. Varian acquires, buys, purchases Cyberheart.

A CyberHeart cardiac ablation radiotherapy treatment plan showing where the radiation beams will ablate for a noninvasive pulmonary vein isolation procedure to treat an arrhythmia.

Feature | Radiation Therapy | May 10, 2019
May 10, 2019 — Radiation oncology vendor Varian announced it acquired the start-up company CyberHeart, which has deve
The novel nanoparticle is designed to enhance radiation killing of cancer cells in the radiation resistant low-oxygen tumor core

The novel nanoparticle is designed to enhance radiation killing of cancer cells in the radiation resistant low-oxygen tumor core. Credit: Wenpei Fan, LOMIN Laboratory, NIBIB.

News | Radiation Therapy | May 08, 2019
Radiation kills tumors by creating oxygen free radicals that damage the tumor DNA. However, the lack of oxygen in the...
Netherlands Proton Therapy Center Delivers First Clinical Flash Irradiation
News | Proton Therapy | May 02, 2019
IBA (Ion Beam Applications SA) recently announced the first Flash irradiation in an IBA proton therapy gantry treatment...
Artificial intelligence (AI) was again the hottest topic in radiology, with 11 of the top 20 pieces of content this month relating to AI. These images are a few of the AI technologies highlighted in ITN Editor's Choice video of the most innovative AI technologies highlighted at RSNA 2018.

Artificial intelligence (AI) was again the hottest topic in radiology, with 11 of the top 20 pieces of content this month relating to AI. These images are a few of the AI technologies highlighted in ITN Editor's Choice video of the most innovative AI technologies highlighted at RSNA 2018. 

Feature | May 01, 2019
May 1, 2019 — Here is the list of the most popular content on the Imaging Technology New (ITN) magazine webs
Pencil Beam Scanning Better Protects Children With Brain Tumors
News | Proton Therapy | May 01, 2019
A comparison of three types of radiotherapy for children's brain tumors suggests a type of proton therapy called pencil...
Researchers Identify Ways to Predict and Avoid Radiotherapy Side Effects
News | Radiation Therapy | April 30, 2019
New research has shown a combination of biological markers and certain genetic changes can predict radiation...