News | May 22, 2015

IOCM agent reduces risk of renal and cardiac events versus low-osmolar contrast media

Visipaque, IOCM, LOCM, angioplasty, EuroPCR 2015

May 22, 2015 — Significantly fewer renal and cardiac events are associated with angioplasty procedures using isosmolar contrast medium (IOCM) agent Visipaque (iodixanol) than those using low-osmolar contrast media (LOCM), according to new data presented at EuroPCR 2015.

The abstracts are based on a study that analyzed data from 334,001 angioplasty procedures from the Premier hospital database in the United States and was funded by GE Healthcare. The results showed 10.5 percent fewer major adverse renal and cardiac events (MARCE) when Visipaque was used compared to LOCM (p<0.01). Those hospitals that only used IOCM or LOCM observed an even greater benefit with 26.7 percent fewer MARCE events in the group receiving IOCM compared to LOCM. Visipaque was more frequently used in angioplasty procedures amongst the elderly and more critical patients as measured by the Charlson Comorbidity Index.

“The results of this study are highly encouraging and support the use of isosmolar contrast media in high-risk percutaneous coronary intervention. These data suggest that prior studies with signal of reduced risk of contrast-induced acute kidney injury with Visipaque do indeed translate into a reduction in clinically meaningful major adverse cardiac and renal events,” said Peter McCullough, M.D., vice chief of medicine at Baylor University Medical Center, Dallas.

This extensive retrospective study — based on patient billing, hospital cost and coding history data collected between January 2008 and September 2013 — evaluated 334,001 angioplasty procedures. IOCM was used in 30.8 percent of cases and the angioplasty procedures that used Visipaque were in older patients (66.8 years versus 63.8, p<0.01) and sicker patients based on the Charlson Comorbidity Index (4.0 versus 3.4, p<0.01). IOCM was also used in more emergency procedures and with more patients who were classified as major or extreme on the 3M APR-DRG Mortality and Severity Indexes than LOCM.

After controlling for patient demographics, comorbid conditions, year, hospital characteristics and variations using the hospital fixed effect specification method, the results from the study found:

Additional findings included:

  • 2.7 percent fewer renal failure events were observed with use of IOCM compared to LOCM
  • 0.6 percent fewer kidney injury events were observed with use of IOCM compared to LOCM

 

For more information: www.gehealthcare.com

Related Content

News | Coronavirus (COVID-19)

November 24, 2021 — Significant decreases in CT imaging for cancer persisted even after the peak of the COVID-19 ...

Time November 24, 2021
arrow
News | Magnetic Resonance Imaging (MRI)

November 23, 2021 — Researchers at Yale University analyzing specialized MRI exams found significant changes in the ...

Time November 23, 2021
arrow
News | Interventional Radiology

November 23, 2021 — A minimally invasive ablation procedure offers long-term relief for patients who experience chronic ...

Time November 23, 2021
arrow
News | Magnetic Resonance Imaging (MRI)

November 22, 2021 — Adolescents and young adults with post-concussive symptoms who suffered three to five concussions ...

Time November 22, 2021
arrow
News | Artificial Intelligence

November 18, 2021 — VIDA Diagnostics Inc. (VIDA) is further removing friction in respiratory clinical trials with the ...

Time November 18, 2021
arrow
News | Radiation Therapy

November 17, 2021 — Radiation can be a powerful cancer therapy, but it doesn’t work for everyone. A new study identifies ...

Time November 17, 2021
arrow
News | Prostate Cancer

November 16, 2021 — A new Harvey L. Neiman Health Policy Institute study of nearly 800,000 men found that between 2011 ...

Time November 16, 2021
arrow
Feature | Breast Density | By Robert L. Bard, M.D. DABR, FASL and Noelle Cutter, Ph.D.

Prologue In 2014, Imaging Technology News (ITN) introduced breast cancer survivor-turned-crusader Nancy Cappello, Ph.D ...

Time November 09, 2021
arrow
News | Coronavirus (COVID-19)

November 5, 2021 — The damage caused by Covid-19 to the lungs’ smallest blood vessels has been intricately captured ...

Time November 05, 2021
arrow
Feature | Radiology Business | Melinda Taschetta-Millane

November 2, 2021 — Here is a list of the Top 10 most popular pieces of content on ITNonline.com from the month of ...

Time November 02, 2021
arrow
Subscribe Now