News | July 18, 2011

Cardinal Health Launches Molecular Imaging Collaboration Center

July 18, 2011 — Cardinal Health opened The Center for the Advancement of Molecular Imaging on Monday in Phoenix. The center is a new, first-of-its-kind collaboration laboratory that will expedite the development of nuclear imaging agents that treat complex diseases like cancer, heart disease and neurological disorders. 

Cardinal Health’s industry-leading scientists, engineers and manufacturing experts will leverage state-of-the-art technology and infrastructure at the newly renovated and expanded 25,000-square-foot campus to help pharmaceutical companies and academic research institutions accelerate the development, testing and commercialization of new radiopharmaceuticals and positron emission tomography (PET) imaging agents. They will also leverage the center to improve the manufacturing and dispensing process for imaging agents. 

The center brings more than 20 new, high-tech jobs to Phoenix, including roles for radiochemists, engineers, scientists, product development managers, project managers and quality and regulatory personnel.  

The campus will house large-scale facilities to produce positron emission tomography (PET) imaging agents. When injected into the body, these specialized radiopharmaceuticals, called biomarkers, detect and trace abnormal cellular functions that are associated with a variety of diseases. Visible using sophisticated imaging scanners, these biomarkers make it easier for physicians to non-invasively diagnose critical, life-threatening diseases in their earliest stages. They can also improve physicians’ ability to track the effectiveness of patient treatment plans.

“The launch of the Center for the Advancement of Molecular Imaging is a strategic investment in the future of the molecular imaging and pharmaceutical industries,” said John Rademacher, president of Cardinal Health’s nuclear and pharmacy services. “By helping pharmaceutical companies and academic research institutions accelerate innovation and reduce the time it takes to get new imaging agents to market, we can more accurately diagnose diseases earlier in their onset. Ultimately, our goal is also to drive better patient outcomes by helping physicians track how well patients are responding to treatments."

The center will also house stand-alone laboratory space to allow the company’s partners to conduct confidential radiopharmaceutical and PET biomarker experiments. It will also provide access to the quality and regulatory expertise that is critical to earning U.S. Food and Drug Administration (FDA) approval of new imaging agents, and will house a global training facility for Cardinal Health’s nuclear pharmacy services business.

At the center, Cardinal Health will leverage its considerable expertise in lean six sigma methodology – capabilities that simplify processes and eliminate process waste – to improve the quality, reliability and scalability of PET manufacturing.  Rademacher says these steps are critical to helping the industry develop large-scale commercial production capabilities that can more easily ramp up to meet growing market demand for new radiopharmaceuticals.

Once new PET drugs are FDA-approved, pharmaceutical companies and research institutions will also have access to Cardinal Health’s industry-leading network of manufacturing facilities and its nationwide network of more than 155 nuclear pharmacies. More than 100 of these nuclear pharmacies are “PET-enabled” to prepare and dispense high-energy PET imaging agents in unit dose form to more than 90 percent of the U.S. patient population. 

Key features of The Center for the Advancement of Molecular Imaging include:

Collaboration laboratory: The center will house “collaborative laboratories” where Cardinal Health will bring industry innovators together with its experts in the fields of scientific research, technology, quality and regulatory affairs and manufacturing. These cross-functional teams will increase the speed of innovation by finding new ways to decrease the time it takes to secure FDA approval of new imaging agents and by sharing best practices for commercialization.

State-of-the-art PET manufacturing facility: The center will house the latest technology in PET manufacturing, including dual cyclotrons, which can be used to produce large quantities of radioisotopes. It will also contain production facilities that allow for the simultaneous radiosynthesis of multiple imaging agents, for both commercial and research purposes. 

Fully functional, confidential, private guest laboratories: The center will have dedicated, fully equipped laboratories where guest researchers can conduct experiments that will produce, test and develop radioactive products, with the goal of supporting more rapid deployment into large-scale, multi-site clinical trials. 

Global PET Production Control Center: The center will also make it easier for pharmaceutical companies and academic institutions to monitor the production of their drugs at any of Cardinal Health’s PET manufacturing sites during multi-site clinical trials. The center’s PET production control center will provide video access to each of Cardinal Health’s PET manufacturing sites, effectively serving as a “mission control,” where partners can trouble shoot, offer technical assistance and more efficiently deploy resources against manufacturing challenges.

For more information: www.cardinalhealth.com

Related Content

University of Missouri Research Reactor First U.S. I-131 Supplier in 30 Years

MURR is the only supplier of I 131 in the United States and the first U.S. supplier since the 1980s. Image courtesy of University of Missouri

News | Radiopharmaceuticals and Tracers | November 13, 2018
The University of Missouri Research Reactor (MURR) recently shipped its first batch of Iodine-131 (I-131), a...
MEDraysintell Projects Increasing Mergers and Acquisitions in Nuclear Medicine
News | Nuclear Imaging | November 07, 2018
With the recent announcement by Novartis to acquire Endocyte , interest from the conventional pharmaceutical industry...
CORAR Supports Medicare Diagnostic Radiopharmaceutical Payment Equity Act of 2018
News | Radiopharmaceuticals and Tracers | October 12, 2018
October 12, 2018 — The Council on Radionuclides and Radiopharmaceuticals Inc.
PET Imaging Agent Predicts Brain Tau Pathology, Alzheimer's Diagnosis
News | PET Imaging | September 05, 2018
Eli Lilly and Co. and Avid Radiopharmaceuticals Inc. announced a Phase 3 study of positron emission tomography (PET)...
Abnormal Protein Concentrations Found in Brains of Military Personnel With Suspected CTE

Researchers are using the tracer, which is injected into a patient, then seen with a PET scan, to see if it is possible to diagnose chronic traumatic encephalopathy in living patients. In this image, warmer colors indicate a higher concentration of the tracer, which binds to abnormal proteins in the brain. Credit UCLA Health.

News | PET Imaging | August 24, 2018
August 24, 2018 — In a small study of
PET/CT Changes Care for 59 Percent of Suspected Recurrent Prostate Cancer Cases
News | Prostate Cancer | June 13, 2018
A recently presented investigational clinical trial evaluated the impact of 18F fluciclovine positron emission...
PET Imaging Agent Could Provide Early Diagnosis of Rheumatoid Arthritis

Coronal 18F-FEDAC PET/CT section of a mouse with collagen-induced arthritis. (A) On day 23 and day 37, increased uptake is noted in the front and hind paws of this mouse with collagen-induced arthritis. (B) Predictive performance of day 23 18F-FEDAC uptake for the development of clinical arthritis. ROC = receiver operating characteristic; Sn = sensitivity; Sp = specificity. Credit: Seoul National University and Ewha Womans University, Seoul, South Korea

News | PET Imaging | May 17, 2018
A novel positron emission tomography (PET) tracer developed by Korean researchers can visualize joint inflammation and...
News | Radiopharmaceuticals and Tracers | May 09, 2018
Blue Earth Diagnostics signed an exclusive, worldwide agreement with Scintomics GmbH, Germany, a specialist in...
Novel PET Agent Could Help Guide Therapy for Brain Diseases

Rat brain 11C‐Me‐NB1 PET images (0‐60 min) superimposed on an MRI template. Credit: SD Krämer et al., ETH Zurich, Zurich, Switzerland

News | PET Imaging | April 10, 2018
Researchers have developed a new imaging agent that could help guide and assess treatments for people with various...