News | April 27, 2009

BSGI Identifies Cancers Mammography Missed

April 27, 2009 - An additional breast cancer was found in 9 percent of patients when breast-specific gamma imaging (BSGI) was used to complement mammography, according to a study from Beth Israel Medical Center, New York, presented at the American Society of Breast Surgeons 2009 Annual Meeting in San Diego.

The study found that of a total of 82 patients who underwent BSGI for newly diagnosed breast cancer, 18 had an additional abnormality, and 17 were biopsied.

BSGI, a molecular breast imaging technique, is an adjunct to mammography that can see lesions independent of tissue density and discover early stage cancers. With BSGI, the patient receives a pharmaceutical tracing agent that is absorbed by all the cells in the body. Due to their increased rate of metabolic activity, cancerous cells in the breast absorb a greater amount of the tracing agent than normal, healthy cells and generally appear as "dark spots" on the BSGI image. The Dilon 6800 Gamma Camera is a high-resolution, compact gamma camera, optimized to perform BSGI.

"We wanted to determine the number of patients with known breast cancer who were found to have an additional lesion detected by BSGI, but undetected by mammography," said Susan K. Boolbol, M.D., chief of breast surgery at Beth Israel Medical Center, New York. "In our study group, 22 percent of patients had a change in surgical management based on BSGI findings. This is critical information in our desire to diagnose breast cancer early for successful treatment."

BSGI provides the capability of helping differentiate cancer from other structures or benign tissue in the breast. Unlike mammography, BSGI is not affected by tissue density. The test is especially useful for patients who have dense breasts, scar tissue, implants, or palpable lesions that cannot be detected using mammography or ultrasound.

Boolbol and her team conducted an IRB-approved review of all patients who underwent BSGI at Beth Israel Medical Center from 2005 to 2008. A total of 82 patients underwent BSGI for newly diagnosed breast cancer. There were five cases of invasive ductal carcinoma, two DCIS, one LCIS, two papillomas, and eight benign biopsies. One patient proceeded directly to mastectomy and an area of DCIS was found, which corresponded to the BSGI.

In the study group, 22 percent of patients had a change in surgical management based on BSGI findings. BSGI detected additional cancer in 9 percent of patients.

"We know that mammography will not detect all breast cancers. This study proves that BSGI is an additional tool to detect breast cancers otherwise missed by standard imaging. Therefore, BSGI plays an important role in the clinical management of patients with known breast cancer," said Dr. Boolbol.

For more information: www.dilon.com

Related Content

Breast Cancer Follow-up Imaging Varies Widely
News | Breast Imaging | July 13, 2018
July 13, 2018 — Follow-up imaging for women...
Invision Diagnostics Installs VolparaEnterprise Software to Enhance Mammography Image Quality
News | Mammography | July 11, 2018
Invision Diagnostics, a provider of mobile mammography services across North and South Carolina, announced that it is...
Hologic Announces Availability of Viera Portable Breast Ultrasound System
Technology | Ultrasound Women's Health | July 11, 2018
Hologic’s new Viera portable breast ultrasound system is now available for purchase in the United States and Europe....
Jeffrey Hoffmeister, M.D.

Jeffrey Hoffmeister, M.D.

Feature | Breast Imaging | July 05, 2018 | By Jeffrey Hoffmeister, M.D.
When women reach age 40, an annual mammogram becomes a necessary part of their healthcare ritual — regardless if they...
Researcher Investigates Eliminating Radiation for HER2-Positive Breast Cancer
News | Radiation Therapy | July 02, 2018
Researchers at The University of Kansas Cancer Center have launched a clinical trial that eliminates radiation from the...
Norwegian Study Confirms Higher Cancer Rate in Women with Dense Breast Tissue
News | Breast Density | July 02, 2018
A large Norwegian study using automated breast density measurements found that women with mammographically dense breast...
3-D Imaging and Computer Modeling Capture Breast Duct Development

An image of a developing mammary duct. Image courtesy of Andrew Ewald.

News | Breast Imaging | June 28, 2018
A team of biologists has joined up with civil engineers to create what is believed to be the first 3-D computer model...
FDA Article Underscores Benefits of Adequate Breast Compression for Mammography Image Quality
News | Mammography | June 26, 2018
Inadequate breast commission played a role in up to 38 percent of mammogram image quality deficiencies, according to a...
Clinical Trial Testing Topical Gel to Reduce Breast Density
News | Breast Density | June 19, 2018
Women with dense breast tissue soon might be adding a new product to their skincare routine to help them fight breast...
California Women In Favor of Extending State's Breast Density Inform Law
News | Breast Density | June 15, 2018
A recent survey of California women found that 95 percent of respondents want the state’s breast density inform law to...
Overlay Init