News | Mammography | December 08, 2017

Study of more than 130,000 mammograms shows optimal compression pressure may improve recall rates, false positives and interval cancer rates

Breast Cancer Screening Performance Impacted by Mean Mammographic Compression Pressure

December 8, 2017 — Dutch researchers demonstrated a strong relationship between compression pressure in mammography and breast cancer screening performance. Involving more than 130,000 mammograms from the Dutch Breast Screening Program and Volpara software, the study showed that very high pressure is linked with reduced sensitivity and very low pressure translates to low specificity.

The study, "Influence of breast compression pressure on the performance of population-based mammography screening," was published in the current issue of Breast Cancer Research. In this study, the data are adjusted for volumetric density and breast volume when evaluating the impact of pressure on screening performance. Katherina Holland, Nico Karssemeijer and researchers from Radboud University Medical Centre in Nijmegen, Netherlands, measured mean compression pressure for 132,776 digital mammograms. Volumetric breast density and pressure was measured using Volpara software. The data was subdivided into five quintiles of mean pressure and the number of screen-detected cancers, interval cancers, false positives and true negatives were available for each group.

The results bolster a growing body of research that suggest that mean compression pressure is related to screening performance, with compression pressures in lower ranges leading to a higher recall rate and a higher false positives fraction, and compression pressures in the higher ranges reducing detectability of breast cancer. These findings are consistent with results from the Norwegian Breast Screening Program recently published in Breast Cancer Research and Treatment.

"Lack of consistent guidelines for mammographic compression can lead to a wide variation in execution. The study shows that adequate compression pressure is crucial for obtaining high quality exams. Both very high and very low mean compression pressure can adversely affect mammography quality. Therefore, it is reasonable to suggest that standardizing to an intermediate compression pressure may lead to better screening outcomes and a better patient experience," said Karssemeijer.

For more information: www.sigmascreening.com


Related Content

News | Breast Imaging

September 26, 2022 — The U.S. Food and Drug Administration (FDA) has granted QT Imaging, Inc. 510(K) clearance to ...

Time September 26, 2022
arrow
News | Breast Density

September 22, 2022 — DenseBreast-info.org (DB-i) announced that it will host the inaugural #WorldDenseBreastDay on ...

Time September 22, 2022
arrow
News | Ultrasound Women's Health

September 21, 2022 — Butterfly Network, Inc. (NYSE: BFLY), a digital health company transforming care through the power ...

Time September 21, 2022
arrow
Feature | Breast Imaging | By Christine Book

Findings from a clinical trial that used artificial intelligence (AI) in an effort to reduce false positives on breast ...

Time September 21, 2022
arrow
News | Women's Health

September 20, 2022 — Scientists from The Tisch Cancer Institute have uncovered a mechanism by which certain breast ...

Time September 20, 2022
arrow
News | MRI Breast

September 16, 2022 — According to ARRS’ American Journal of Roentgenology (AJR), the contrast-enhanced in-phase Dixon ...

Time September 16, 2022
arrow
News | Magnetic Resonance Imaging (MRI)

September 15, 2022 — University of Minnesota Twin Cities scientists and engineers have found a way to improve the ...

Time September 15, 2022
arrow
News | Radiation Therapy

September 15, 2022 — The intestine is very susceptible and is affected by the harsh conditions caused by DNA-altering ...

Time September 15, 2022
arrow
News | Breast Imaging

September 14, 2022 — When double reading screening mammograms, radiographers (technologists) trained for the task ...

Time September 14, 2022
arrow
News | Ultrasound Imaging

September 9, 2022 — Boston Imaging, the United States headquarters of Samsung digital radiography and ultrasound ...

Time September 09, 2022
arrow
Subscribe Now