News | Artificial Intelligence | December 11, 2019

This deep learning approach could also have applications for other neurological conditions, according to researchers

Schematic diagram of the proposed multichannel deep neural network model analyzing multiscale functional brain connectome for a classification task. rsfMRI = resting-state functional MRI.

Schematic diagram of the proposed multichannel deep neural network model analyzing multiscale functional brain connectome for a classification task. rsfMRI = resting-state functional MRI. Graphic courtesy of the Radiological Society of North America.


December 11, 2019 — Deep learning, a type of artificial intelligence, can boost the power of magnetic resonance imaging (MRI) in predicting attention deficit hyperactivity disorder (ADHD), according to a study published in Radiology: Artificial Intelligence. Researchers said the approach could also have applications for other neurological conditions.

The human brain is a complex set of networks. Advances in functional MRI, a type of imaging that measures brain activity by detecting changes in blood flow, have helped with the mapping of connections within and between brain networks. This comprehensive brain map is referred to as the connectome.

Increasingly, the connectome is regarded as key to understanding brain disorders like ADHD, a condition that makes it difficult for a person to pay attention and control restless behavior.

According to the National Survey of Children's Health, approximately 9.4 percent of U.S. children, ages 2 to 17 years (6.1 million) in 2016 have been diagnosed with ADHD. The disorder cannot yet be definitively diagnosed in an individual child with a single test or medical imaging exam. Instead, ADHD diagnosis is based on a series of symptoms and behavior-based tests.

Brain MRI has a potential role in diagnosis, as research suggests that ADHD results from some type of breakdown or disruption in the connectome. The connectome is constructed from spatial regions across the MR image known as parcellations. Brain parcellations can be defined based on anatomical criteria, functional criteria, or both. The brain can be studied at different scales based on different brain parcellations.

Prior studies have focused on the so-called single-scale approach, where the connectome is constructed based on only one parcellation. For the new study, researchers from the University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center took a more comprehensive view. They developed a multi-scale method, which used multiple connectome maps based on multiple parcellations.

To build the deep learning model, the researchers used data from the NeuroBureau ADHD-200 dataset. The model used the multi-scale brain connectome data from the project's 973 participants along with relevant personal characteristics, such as gender and IQ.

The multi-scale approach improved ADHD detection performance significantly over the use of a single-scale method.

"Our results emphasize the predictive power of the brain connectome," said study senior author Lili He, Ph.D., from the Cincinnati Children's Hospital Medical Center. "The constructed brain functional connectome that spans multiple scales provides supplementary information for the depicting of networks across the entire brain."

By improving diagnostic accuracy, deep-learning-aided MRI-based diagnosis could be critical in implementing early interventions for ADHD patients. Approximately 5 percent of American pre-school and school-aged children have been diagnosed with ADHD. These children and adolescents face a high risk of failing in academic study and building social relationships, which can result in financial hardship for families and create a tremendous burden on society.

The approach also has potential beyond ADHD, according to He.

"This model can be generalized to other neurological deficiencies," she said. "We already use it to predict cognitive deficiency in pre-term infants. We scan them soon after birth to predict neurodevelopmental outcomes at two years of age."

In the future, the researchers expect to see the deep learning model improve as it is exposed to larger neuroimaging datasets. They also hope to better understand the specific breakdowns or disruptions in the connectome identified by the model that are associated with ADHD.

For more information: www.RadiologyInfo.org


Related Content

News | SIIM

June 20, 2024 — The Society for Imaging Informatics in Medicine (SIIM) is gearing up for its SIIM24 Annual Meeting and ...

Time June 20, 2024
arrow
News | MRI Breast

June 12, 2024 — Royal Philips recently announced the 1,111th installation of its revolutionary BlueSeal 1.5T magnet ...

Time June 12, 2024
arrow
News | Digital Radiography (DR)

June 6, 2024 — In a landmark study, the latest in technology innovation by Konica Minolta Healthcare was used to develop ...

Time June 06, 2024
arrow
News | Radiology Imaging

June 5, 2024 — RadiologyInfo.org, a leading source of medical imaging information for the general public, has introduced ...

Time June 05, 2024
arrow
News | Breast Imaging

June 4, 2024 — Using artificial intelligence (AI), breast radiologists in Denmark have improved breast cancer screening ...

Time June 04, 2024
arrow
Feature | Artificial Intelligence

Did you know that approximately one-third of all the data in world is created by the healthcare industry and that ...

Time June 03, 2024
arrow
News | Magnetic Resonance Imaging (MRI)

May 31, 2024 — Low-level light therapy appears to affect healing in the brains of people who suffered significant brain ...

Time May 31, 2024
arrow
News | Lung Imaging

May 31, 2024 — To further the fight against global lung cancer, Qure.ai, a leader in healthcare artificial intelligence ...

Time May 31, 2024
arrow
News | RSNA

May 29, 2024 — The Radiological Society of North America (RSNA) has launched the 2024 RSNA Lumbar Spine Degenerative ...

Time May 29, 2024
arrow
News | Radiology Business

May 29, 2024 — Strategic Radiology added a third California member to the nation’s leading coalition of independent ...

Time May 29, 2024
arrow
Subscribe Now