Breast Imaging

Images show symptomatic false-negative cancer in a 73-year-old black woman who presented with a palpable abnormality 64 days after negative screening mammography. (a) Negative screening left digital breast tomosynthesis (DBT) mammogram. (b) Diagnostic DBT mammogram shows a new palpable mass (arrow). (c) Spot-compression DBT mammogram enables confirmation of mass (arrow). (d) Ultrasound (US) image shows hypoechoic mass with angular margins. Subsequent US-guided biopsy revealed estrogen receptor- and progesterone receptor-positive and human epidermal growth factor receptor 2-negative invasive ductal carcinoma. Image courtesy of Radiological Society of North America

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A deep learning model was developed that combined imaging and traditional risk factors.

Images in a 55-year-old woman with a spiculated mass localized in the upper central quadrant (arrow in A, B, D, and E) of right breast detected with digital breast tomosynthesis (DBT) plus synthetic mammography (SM). Breast density was classified as category C with the Breast Imaging Reporting and Data System. Mass was invasive ductal carcinoma, stage I, and was estrogen and progesterone receptor positive and human epidermal growth factor receptor 2 negative. A, Image from SM in craniocaudal view. B, Single-slice DBT image in craniocaudal view. C, Magnification of the lesion depicted in B. D, Image from SM in mediolateral oblique view. E, Single-slice DBT image in mediolateral oblique view. F, Magnification of the lesion depicted in E. Images courtesy of Radiological Society of North America