Feature | March 09, 2015

PET/MR Can Effectively Diagnose Cause of Unclear Foot Pain

Study finds PET/MR image quality, diagnostic certainty higher than PET/CT

SNMMI, PET/MRI, PET/CT, foot pain, diagnosis, nuclear imaging

March 9, 2015 — A single scan could diagnose the cause of foot pain better and with less radiation exposure to the patient than other methods, according to a study in the March 2015 issue of The Journal of Nuclear Medicine. Imaging with 18F-fluoride positron emission tomography/magnetic resonance imaging (PET/MR), compared to 18F-fluoride positron emission tomography/computed topography (PET/CT), provides more diagnostic information with higher diagnostic certainty.

Foot pain is a common problem in the daily routine of any orthopedic surgeon. It can be a clinical symptom of many different issues, from stress fractures to tumors. Multiple imaging modalities are available to help diagnose specific types of foot pain, but no one modality is useful for effectively diagnosing a wide range of causes. Imaging with 18F-fluoride PET is a highly sensitive tool but has low specificity for detection of metabolically active benign bone disease, while MR imaging provides excellent soft-tissue contrast and high resolution, which helps in specifying a diagnosis. Thus, combined, PET/MR can offer an important tool for the sensitive diagnosis of foot pathologies.

In “Evaluation of 18F-Fluoride PET/MR and PET/CT in Patients with Foot Pain of Unclear Cause,” researchers compared the quality and diagnostic performance of 18F-fluoride PET/MR to those of 18F-fluoride PET/CT in 22 patients for whom the specific diagnosis was inconclusive after clinical examination and radiography. The results of overall image quality showed that PET/MR was significantly superior to PET/CT, with an overall excellent image quality score of 3.0/3 points in all PET/MR datasets, while PET/CT achieved 2.3 out of 3 possible points.

“In our study, 18F-fluoride PET/MR provided more diagnostic information at a higher diagnostic certainty compared to 18F-fluoride PET/CT in patients with foot pain of unclear cause,” stated Isabel Rauscher, corresponding author of the study. “Besides information on bone metabolism, it provides additional diagnostic-relevant findings from soft-tissue and bone marrow pathology (e.g., bone marrow edema, ganglion cysts or tenosynovitis) compared to PET/CT.” Also, since MR involves no radiation and the scan allows a longer PET acquisition time, the patient’s exposure is lower than with CT.

For more information: www.snmmi.org

Related Content

 Prostate cancer MRI
News | Clinical Trials | November 15, 2019
November 15, 2019 — Theragnostics, which is developing innovative radiopharm
An image on Brigham and Women's Hospital's 7T MRI system

An image on Brigham and Women's Hospital's 7T MRI system. Image courtesy of Brigham and Women's Hospital

News | Magnetic Resonance Imaging (MRI) | November 13, 2019
November 13, 2019 — Increased immune system activity along the surface of the brain, or meningeal inflammation, may b
Image by Dr. Manuel González Reyes from Pixabay

Image by Dr. Manuel González Reyes from Pixabay 

News | SPECT Imaging | November 08, 2019
November 8, 2019 — Using ground-breaking technology, researchers at the...
This chest X-ray of a patient being treated for e-cigarette or vaping-associated lung injury shows lung opacities, densities and whitish cloud-like areas which are typically seen with unusual pneumonias, fluid in lungs or lung inflammation. Image courtesy of Intermountain Healthcare

This chest X-ray of a patient being treated for e-cigarette or vaping-associated lung injury shows lung opacities, densities and whitish cloud-like areas which are typically seen with unusual pneumonias, fluid in lungs or lung inflammation. Image courtesy of Intermountain Healthcare

News | Clinical Trials | November 08, 2019
November 8, 2019 — As the outbreak of lung injuries and deaths associated with e-cigarettes, or...
Unlike other technologies for imaging the placenta, pCASL MRI can distinguish maternal blood from fetal blood

Image courtesy of Pixabay

News | Clinical Trials | November 07, 2019
November 7, 2019 — A new imaging technique to track
Philips Medical System is recalling its older Forte Gamma Camera SPECT imaging systems due to the possibility of the detectors falling off of the unit onto the patient. The two gamma cameras can bee seen in this photo on either side of the patient bed. These can be rotated above the patient.

Philips Medical System is recalling its older Forte Gamma Camera SPECT imaging systems due to the possibility of the detectors falling off of the unit onto the patient. The two gamma cameras can be seen in this photo on either side of the patient bed. These can be rotated above the patient.

Feature | Nuclear Imaging | November 05, 2019 | Dave Fornell, Editor
November 5, 2019 — Philips Medical System is recalling the Forte Gamma Camera System due to the potential for the 660
The Neuroreader software program quantifies brain volume in study participants with TBI

The Neuroreader software program quantifies brain volume in study participants with TBI. Image courtesy of UCLA Health.

News | Clinical Trials | October 29, 2019
October 29, 2019 — A UCLA-led...
 Phoenix’s fusion neutron generation technology.
News | Radiopharmaceuticals and Tracers | October 28, 2019
October 28, 2019 — Phoenix LLC and Shine Medical Technologies LLC, nuclear technology companies focused on near-term
Breast Tomosynthesis Increases Cancer Detection Over Digital Mammography
News | Mammography | October 23, 2019
Screening digital breast tomosynthesis (DBT) results in “significantly increased CDR [cancer detection rates]” compared...