Computer-aided detection (CAD) is a valuable tool in the radiologist’s armamentarium. However, the path of technological advancement has not been without bumps in the road. Issues surrounding “the doubt” have included the effect upon false positive rates, callbacks, biopsy rates, overall detection rates, clinical decision-making and patient outcomes. For the many studies supporting the efficacy of CAD applications for breast, lung and colon, there are many others that have produced unfavorable results, casting a continued shadow of doubt over its utility.
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