Journal of Women's Health, published monthly, is a core multidisciplinary journal dedicated to the diseases and conditions that hold greater risk for or are more prevalent among women.
New technology and better screening strategies can lower the rate of false-positive results, which impose a substantial financial and psychological burden on women. The many misperceptions about breast cancer screening options and risks, the benefits and costs of screening, and the need for new approaches and better education are discussed in a series of articles in a supplement to Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The supplement is available free on the Journal of Women's Health website at http://online.liebertpub.com/toc/jwh/23/S1.
In the article "The Patient Burden of Screening Mammography Recall," the authors reported that among more than 1.7 million women aged 40-75 who underwent screening mammography and were not diagnosed with breast cancer, 15 percent were recalled for further testing. The cumulative risk of a false-positive result after 10 years of annual screening mammograms is an estimated 61 percent. Coauthors Matthew Alcusky, PharmD, Janice Clarke, RN, and Alexandria Skoufalos, EdD, Jefferson School of Population Health; Liane Philpotts, MD, FSBI, Yale University School of Medicine; and Machaon Bonafede, Ph.D., MPH, Truven Health Analytics, evaluated the direct cost burden of recall, the indirect costs associated with missed work time, travel, and substitute caregivers, for example, and the physical or psychological effects of a false-positive result, which may include unnecessary anxiety and reduced quality of life.
In an accompanying review article on "Understanding Patient Options, Utilization Patterns and Burdens Associated with Breast Cancer Screening," authors Susan C. Harvey, M.D., Johns Hopkins Medical Institutions; Sharon Mass, M.D., FACOG, Morristown Obstetrics and Gynecology Associates; and Ashok Vegesna, PharmD, Janice Clarke, RN, and Alexandria Skoufalos, EdD, Jefferson School of Population Health, attributed much of the confusion women face in making informed decisions about breast cancer screening and recall options to a lack of consensus among the organizations developing screening guidelines and the mixed messages they deliver. The authors called for a more thoughtful approach to breast cancer screening and research that takes into account the tangible and intangible costs that women now bear.
"The articles in this supplement are timely and reveal surprisingly complex issues," said Susan C. Harvey, M.D., in her editorial, "The Charge and the Challenges of Breast Cancer Screening." Collectively, the articles "illustrate the need for a more tailored approach to breast cancer awareness, education, and screening. The goal is to make appropriate screening and diagnosis easier on women and more responsive to the changing face of value-based health care."
"The direct and indirect cost burden of inconclusive mammography screenings and recalls is significant and indicates a need for new approaches to breast cancer screening," said Susan G. Kornstein, M.D., editor-in-chief of Journal of Women's Health, executive director of the Virginia Commonwealth University Institute for Women's Health, Richmond, Va., and president of the Academy of Women's Health.
January 29, 2026 
