News | March 17, 2010

Two-Week Break in Radiation Therapy Offers a Safe Option

March 17, 2010 - Researchers found a two-week break in radiation therapy for patients with stage I small cell lung cancer, who have gone through surgery, reduced patients' symptoms without adversely affecting cancer survival, reports the February issue of the Journal of Thoracic Oncology.

While the majority of lung cancer patients present with locally advanced or stage IV disease, the primary challenge in treating them is that most present with poor performance status, and the benefit of treatment may be doubtful because of poor tolerance to any form of therapy.

Palliative chest radiotherapy for lung malignancies has shown to be effective in relieving serious chest symptoms from tumor bleeding or mass effect on major airways, vessels and nerves. However, there is a lack of consensus for an optimal palliative RT regimen.

Researchers sought to assess the overall efficacy of split-course palliative chest RT for symptom relief in patients with advanced non-small cell lung cancer. Additionally, researchers investigated the impact the regimen’s two-week break has on survival outcomes.

Investigators reviewed the records of 140 patients treated between 1995 and 2006, who were prescribed to an initial 25 Gy in 10 fractions through anterior-posterior/posterior-anterior beam arrangements. After two weeks of rest, selected patients were given an additional 10 Gy (anterior-posterior/posterior-anterior) followed by off-cord beams to a final dose of 50 to 62.5 Gy.

Symptomatic relief was observed in 52 to 84 percent of patients with durable palliation in 58 percent. The researchers observed: "The built-in two-week break allowed for selection of patients for high-dose palliative radiation and balanced treatment benefits with potential side effects. Cancer survival was not adversely affected by treatments in this population with mostly advanced disease." The researchers added that the two-week break may be an option for patients who cannot tolerate an uninterrupted course.

Reference: Metcalfe, Su K.; Milano, Michael T.; Bylund, Kevin; Smudzin, Therese; Rubin, Philip; Chen, Yuhchyau. Split-Course Palliative Radiotherapy for Advanced Non-small Cell Lung Cancer. Journal of Thoracic Oncology. 5(2):185-190, February 2010.

For more information: journals.lww.com/jto/toc/2010/02000

Related Content

New Prostate Cancer Radiotherapy Technique Aims to Preserve Sexual Function
News | Radiation Therapy | June 18, 2018
A multicenter clinical trial being led by UT Southwestern physicians is testing a technique for sparing nerve bundles...
Elekta Unity High-Field MR-Linac Receives CE Mark
News | Image Guided Radiation Therapy (IGRT) | June 18, 2018
Elekta announced that its Elekta Unity magnetic resonance radiation therapy (MR/RT) system has received CE mark,...
Washington University in St. Louis Begins Clinical Treatments With ViewRay MRIdian Linac
News | Image Guided Radiation Therapy (IGRT) | June 14, 2018
June 14, 2018 — The Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in S
Accuray TomoTherapy System Beneficial in Two Total Body Irradiation Studies
News | Radiation Therapy | June 13, 2018
Recently published data from two new studies demonstrate the benefits of Accuray’s TomoTherapy System in the delivery...
IsoRay Funding Brain Cancer Treatment Research With Ochsner Clinic Foundation
News | Brachytherapy Systems | June 12, 2018
IsoRay Inc. announced the initiation of research funding for brain cancer treatment to Ochsner Clinic Foundation, a not...
News | Brachytherapy Systems | June 07, 2018
IsoRay Inc. announced the upcoming release of its Build-Blu delivery system for real-time prostate brachytherapy.
Raysearch RayStation
Feature | Radiation Therapy | June 05, 2018 | By Melinda Taschetta-Millane
Treatment planning systems are at the heart of r...
Beaumont Researchers Invent New Mode of Proton Treatment for Lung Cancer
News | Proton Therapy | May 31, 2018
Members of Beaumont Health’s proton therapy team presented research on a new treatment for patients with lung cancer at...
More Than 60 Percent of Patients Seeking Proton Therapy Initially Denied Coverage
News | Proton Therapy | May 25, 2018
The Alliance for Proton Therapy Access has released a national report revealing the heavy emotional and financial...
News | Treatment Planning | May 24, 2018
Daniela Schmitt, Ph.D., took top honors in the overall category of the 2018 TROG Plan Study: Stereotactic Radiosurgery...
Overlay Init