News | Contrast Media | July 05, 2016

Study Finds No Association Between Gadolinium Contrast and Nervous System Disorder

Patients who did not undergo gadolinium-enhanced MRI had same rate of disorder development as those who did

MRI, gadolinium contrast, Parkinsonism, nervous system disorder, Blayne Welk, Western University

July 5, 2016 — A study appearing in the July 5 issue of JAMA assessed the association between gadolinium exposure and parkinsonism, a degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination. The study was conducted by Blayne Welk, M.D., M.Sc., of Western University, London, Canada, and colleagues.

Gadolinium-based contrast agents are used for enhancement during magnetic resonance imaging (MRI). Safety concerns have emerged over retained gadolinium in the globus pallidi (an area of the brain). Neurotoxic effects have been seen in animals and when gadolinium is given intrathecally (a type of method for administering a drug) in humans. Consequences of damage to the globus pallidi may include parkinsonian symptoms. For this study, multiple linked administrative databases from Ontario, Canada were used. All patients older than 66 years who underwent an initial MRI between April 2003 and March 2013 were identified. Patients who were exposed to gadolinium-enhanced MRIs were compared with patients who received non-gadolinium-enhanced MRIs.

Of the 246,557 patients undergoing at least one MRI (not of the brain or spine) during the study period, 99,739 (40.5 percent) received at least one dose of gadolinium. Among patients who underwent gadolinium-enhanced MRIs, 81.5 percent underwent a single study, and 2.5 percent underwent 4 or more gadolinium-enhanced studies. Incident parkinsonism developed in 1.2 percent of unexposed patients and 1.2 percent of those exposed to gadolinium. No significant association between gadolinium exposure and parkinsonism was found.

“This result does not support the hypothesis that gadolinium deposits in the globus pallidi lead to neuronal damage manifesting as parkinsonism. However, reports of other nonspecific symptoms (pain, cognitive changes) after gadolinium exposure require further study,” the authors wrote.

 

Related Gadolinium Safety Concern Articles

Gadolinium May Remain in Brain after Contrast MRI

MRIs During Pregnancy Are Safe, But Gadolinium Scans May Increase Risk to Fetus

ACR Manual on Contrast Media Addresses FDA Gadolinium Safety Concerns

Even High Doses of Gadolinium-Based Contrast Agents Doesn't Cause NSF

 

For more information: www.jama.jamanetwork.com

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