News | Cardio-oncology | May 03, 2017

Strain Imaging Improves Cardiac Surveillance of Certain Breast Cancer Patients

ACC study finds echocardiographic strain may improve management for HER2 breast cancer patients on non-anthracycline trastuzumab-based regimens

Strain Imaging Improves Cardiac Surveillance of Certain Breast Cancer Patients

May 3, 2017 — Epsilon Imaging Inc. announced a research study using EchoInsight was presented at the American College of Cardiology (ACC) 2017 Annual Scientific Session and Expo conference from a team at Northwestern University. 

The study, "Strain Imaging in Breast Cancer Patients treated with Current Non-Anthracycline, Trastuzumab-Based Regimens," was presented by Grier, EA, Akhter N, et al. Until now, trastuzumab is known to increase the risk of cardiotoxicity when combined with anthracycline agents. This study assessed the independent effects of trastuzumab in current non-anthracycline-based regimens on left ventricular function using echocardiographic strain imaging.

Thirty-four patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who were treated with non-anthracycline trastuzumab-based regimens at a single center underwent standard echo studies prior to starting chemotherapy, and again at three-month intervals during therapy. Two-dimensional speckle-tracking strain was retrospectively obtained using EchoInsight software. The results of the study showed 10 patients developing cardiotoxicity during therapy. A significant reduction in global longitudinal strain (GLS) preceded the decrease in LVEF. A significant decrease in global circumferential strain (GCS) was demonstrated after a change in GLS.

"Our study demonstrated that trastuzumab-based regimens demonstrate a risk of cardiotoxicity that is independent of anthracyclines," said Nausheen Akhter, M.D., assistant professor of medicine at Northwestern University and director of cardio oncology at Northwestern Medicine. "Close cardiac surveillance with current non-anthracycline trastuzumab-based regimens is still needed in cardio oncology management."

For more information: www.acc.org

Related Content

Aidoc Introduces AI Solution for Whole-Body CT Scan Analysis
News | Artificial Intelligence | February 20, 2018
Deep learning startup company Aidoc announced what it calls the world’s first and only comprehensive, full-body...
FDA Clears Siemens Healthineers' GOKnee3D MRI Application
Technology | Magnetic Resonance Imaging (MRI) | February 19, 2018
The U.S. Food and Drug Administration (FDA) has cleared GOKnee3D, a magnetic resonance imaging (MRI) application from...
NIH Issues $2.2 Million Grant for Augmented Reality Cardiac Hologram Research
News | Advanced Visualization | February 15, 2018
February 15, 2018 — The National Institutes of Health (NIH) awarded a $2.2 million research grant to healthcare techn
AHRA and Canon Medical Systems Announce 2017 Putting Patients First Grant Winners
News | Patient Engagement | February 14, 2018
The Association for Medical Imaging Management (AHRA) and Canon Medical Systems recently announced the tenth annual...
Patients Lack Information About Imaging Exams
News | Patient Engagement | February 14, 2018
Patients and their caregivers desire information about upcoming imaging examinations, but many are not getting it,...
Digisonics Customers Expand OB Ultrasound Reporting Systems for Improved Workflow Efficiency
News | Ultrasound Imaging | February 06, 2018
February 6, 2018 – Oregon Health and Science University in Portland, Ore., University of Utah Medical Center in Salt
PSMA PET-CT Clearly Differentiates Prostate Cancer from Benign Tissue

68Ga-PSMA PET/CT images showing multifocal PCA in peripheral zone with GS of 5 1 5 5 10. (A and C) Axial PET images. (B and D) Fused PET/CT images. SUVmax of lesion in B was 84.3 and that of lesion in D was 5.7. IRS was 3, and 80% of cells were stained. Credit: Senior author V Prasad, Charité Universitätsmedizin Berlin, Berlin, Germany.

News | PET-CT | February 05, 2018
February 5, 2018 — Using nuclear medicine...
Microbubbles Make Breast Cancer More Susceptible to Radiation Therapy
News | Women's Health | February 01, 2018
February 1, 2018 – Injecting breast cancer with oxygen-filled microbubbles makes tumors three-times more sensitive to
Overlay Init