News | Cardio-oncology | May 03, 2017

ACC study finds echocardiographic strain may improve management for HER2 breast cancer patients on non-anthracycline trastuzumab-based regimens

Strain Imaging Improves Cardiac Surveillance of Certain Breast Cancer Patients

May 3, 2017 — Epsilon Imaging Inc. announced a research study using EchoInsight was presented at the American College of Cardiology (ACC) 2017 Annual Scientific Session and Expo conference from a team at Northwestern University. 

The study, "Strain Imaging in Breast Cancer Patients treated with Current Non-Anthracycline, Trastuzumab-Based Regimens," was presented by Grier, EA, Akhter N, et al. Until now, trastuzumab is known to increase the risk of cardiotoxicity when combined with anthracycline agents. This study assessed the independent effects of trastuzumab in current non-anthracycline-based regimens on left ventricular function using echocardiographic strain imaging.

Thirty-four patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who were treated with non-anthracycline trastuzumab-based regimens at a single center underwent standard echo studies prior to starting chemotherapy, and again at three-month intervals during therapy. Two-dimensional speckle-tracking strain was retrospectively obtained using EchoInsight software. The results of the study showed 10 patients developing cardiotoxicity during therapy. A significant reduction in global longitudinal strain (GLS) preceded the decrease in LVEF. A significant decrease in global circumferential strain (GCS) was demonstrated after a change in GLS.

"Our study demonstrated that trastuzumab-based regimens demonstrate a risk of cardiotoxicity that is independent of anthracyclines," said Nausheen Akhter, M.D., assistant professor of medicine at Northwestern University and director of cardio oncology at Northwestern Medicine. "Close cardiac surveillance with current non-anthracycline trastuzumab-based regimens is still needed in cardio oncology management."

For more information: www.acc.org


Related Content

News | Point-of-Care Ultrasound (POCUS)

May 20, 2024 — Exo (pronounced “echo”), a medical imaging software and devices company, announced the release of Exo ...

Time May 20, 2024
arrow
News | Prostate Cancer

May 13, 2024 — Avenda Health, an AI healthcare company creating the future of personalized prostate cancer care, unveils ...

Time May 13, 2024
arrow
News | Radiology Imaging

May 13, 2024 — National Basketball Association (NBA), the National Basketball Players Association (NBPA), and the Next ...

Time May 13, 2024
arrow
News | Contrast Media

May 8, 2024 — Swedish biotech company Ascelia Pharma AB has announced that its liver imaging drug candidate, Orviglance ...

Time May 08, 2024
arrow
News | Pediatric Imaging

May 2, 2024 — Head and abdominal trauma is a leading cause of death for children. About 1%–2% of children who come to ...

Time May 02, 2024
arrow
News | Proton Therapy

April 29, 2024 — Koneksa, a healthcare technology company pioneering evidence-based digital biomarkers, announced today ...

Time April 29, 2024
arrow
News | Contrast Media

April 24, 2024 — The International Contrast Ultrasound Society (ICUS) and Northwest Imaging Forums (NWIF) announced an ...

Time April 24, 2024
arrow
News | Magnetic Resonance Imaging (MRI)

April 17, 2024 — Hyperfine, Inc., a groundbreaking health technology company that has redefined brain imaging with the ...

Time April 17, 2024
arrow
News | Magnetic Resonance Imaging (MRI)

April 8, 2024 — Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive technique for neuroregulation ...

Time April 08, 2024
arrow
News | Radiology Business

April 4, 2024 — FUJIFILM Healthcare Americas Corporation, a leading provider of diagnostic and enterprise imaging ...

Time April 04, 2024
arrow
Subscribe Now