News | May 11, 2010

SRS Safe, Effective for Children with Arteriovenous Malformations

May 11, 2010 - Stereotactic radiosurgery using gamma knife is a safe and effective option for selected children with arteriovenous malformations, according to a recent study presented at the American Association of Neurological Surgeons Annual Meeting in Philadelphia last week.

An intracranial arteriovenous malformation is an abnormal tangle of blood vessels in the brain. In an arteriovenous malformation, the blood passes directly from arteries to veins via the abnormal vessels, and the brain is not allowed to absorb oxygen from the blood, which can result in stroke-like symptoms, seizures or other symptoms. Arteriovenous malformations appear to be congenital. About 0.14 percent of the population has an arteriovenous malformation.

The gamma knife is a radiosurgical treatment that delivers a dose of gamma radiation to the target with surgical precision. It is also the most accepted and widely used radiosurgery treatment in the world.

"Using stereotactic radiosurgery, focused radiation is directed to the arteriovenous malformation causing the vessels to slowly block off over several years and the majority of patients are protected from the risk of intracranial bleeding," said Bruce Pollock, M.D., a Mayo Clinic neurosurgeon and the author of the study.

Pollock and a team of Mayo Clinic researchers collected data from 48 patients, ages 18 or under, who had Gamma Knife stereotactic radiosurgery for an arteriovenous malformation between 1990 and 2007 and had more than 12 months of follow-up data. Twenty-seven patients (57 percent) had a previous brain hemorrhage, and 15 of the arteriovenous malformations were in deep locations. The team found that 52 percent (25 patients) had obliteration of the malformation after their initial radiosurgery. Repeat radiosurgery was performed in 12 patients, five of whom had obliteration, for a total obliteration rate of 63 percent. Three patients had radiation-related deficits after initial or repeat radiosurgery, but no patients had arteriovenous malformation bleeding, neuro-cognitive decline or radiation-induced tumor after radiosurgery.

"We believe that Gamma Knife stereotactic radiosurgery is a safe treatment option for many children with arteriovenous malformations," said Pollack.

For more information: www.mayoclinic.orgstereotactic-radiosurgery/gamma-knife.html and www.aans.org

Related Content

more healthcare providers and patients are choosing options such as Gamma Knife stereotactic radiosurgery
News | Radiation Therapy | July 31, 2017
Each year, up to 650,000 people who were previously diagnosed with various forms of cancer will develop brain...
Surgery and High-Dose SBRT Radiation Can Be Combined to Treat Kidney Cancer
News | Stereotactic Body Radiation Therapy (SBRT) | July 05, 2017
A new study from Roswell Park Cancer Institute reporting the findings of the first clinical trial to evaluate the...
ASTRO Issues Guideline for Stereotactic Radiation Use in Early-Stage Lung Cancer
Feature | Lung Cancer | June 23, 2017
The American Society for Radiation Oncology (ASTRO) recently issued a new clinical guideline for the use of...
stereotactic body radiation therapy (SBRT)
News | Stereotactic Body Radiation Therapy (SBRT) | June 12, 2017
The American Society for Radiation Oncology (ASTRO) issued a new clinical guideline for the use of stereotactic body...
Stereotactic Radiation Highly Effective for Kidney Cancer
News | Stereotactic Body Radiation Therapy (SBRT) | May 03, 2017
Kidney cancer patients may soon have an alternative to traditional treatments, according to new research at UT...
SBRT, stereotactic body radiation therapy, early-stage lung cancer, patients 80 and older, 2017 Multidisciplinary Thoracic Cancers Symposium, study
News | Stereotactic Body Radiation Therapy (SBRT) | March 20, 2017
Patients in their 80s and 90s who have early-stage lung cancer but cannot undergo an operation can be treated safely...
prostate cancer, partial gland, SBRT, clinical trial, UH Hospitals
News | Stereotactic Body Radiation Therapy (SBRT) | April 28, 2016
Physicians at University Hospitals Seidman Cancer Center (Cleveland) have started a clinical trial using a new form of...
prostate cancer, stereotactic body radiation therapy, SBRT, cure rate, UT Southwestern Study
News | Prostate Cancer | April 19, 2016
A five-year study shows that stereotactic body radiation therapy (SBRT) offers a higher cure rate for prostate cancer...
Overlay Init