News | June 09, 2010

Single Dose IORT for Breast Tumors Found Effective

Intraoperative Radiotherapy (IORT) is used for accelerated, partial breast irradiation.

June 9, 2010 - A single radiation dose during intraoperative radiotherapy (IORT) is at least as effective as longer post-operative treatments, according to results from a study presented at the American Society of Clinical Oncology (ASCO) meeting, held June 4-8 in Chicago and published in the Lancet June 5.

In the study, TARGIT (targeted intraoperative radiotherapy), the radiation therapy is confined to the area of the breast where the tumor has been removed. Researchers reported that TARGIT is as effective at preventing breast cancer recurrence as whole breast radiotherapy and can be completed in one hospital visit.

After surgery to conserve the breast, 90 percent of cancer recurrences occur very near to where the removed tumor was (index quadrant), despite the presence of multicentric cancers elsewhere in the breast. Researchers suggested restriction of radiation therapy to the site of the tumor bed during surgery may be suitable for selected patients. The authors compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

The trial enrolled women aged at least 45 years with invasive ductal breast carcinoma undergoing breast-conserving surgery were enrolled.

A total of 1,113 patients were randomly allocated to targeted intraoperative radiotherapy and 1,119 were allocated to external beam radiotherapy.

Of 996 patients who received the allocated treatment in the targeted intraoperative radiotherapy group:

- 854 (86 percent) received targeted intraoperative radiotherapy only
- 142 (14 percent) received targeted intraoperative radiotherapy plus external beam radiotherapy

There were 1,025 (92 percent) patients in the external beam radiotherapy group received the allocated treatment.

At four years, there were:

- Six local recurrences (of cancer) in the intraoperative radiotherapy group
- Five local recurrences (of cancer) in the external beam radiotherapy group

Occurrence rates in the two groups were similar; 1-20 percent in the targeted intraoperative radiotherapy and 0-95 percent in the external beam radiotherapy group.

The researchers found targeted intraoperative radiotherapy almost completely avoids irradiation of the intrathoracic structures such as the heart, lung, and oesophagus. Consequently, the damage to these structures, which can occur even with modern external beam radiotherapy, will have been avoided.

They wrote in their conclusion: "For selected patients with early breast cancer, a single dose of radiotherapy delivered at the time of surgery by use of targeted intraoperative radiotherapy should be considered as an alternative to external beam radiotherapy delivered over several weeks."

Reference: Vaidya, J., et al. "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, noninferiority phase 3 trial." The Lancet. June 5, 2010. DOI:10.1016/S0140-6736(10)60837-9

For more information: www.thelancet.com

Related Content

First Hospitals Achieve Inter-System Connectivity Across Accuray Radiation Therapy Platforms
News | Radiation Therapy | January 19, 2018
Accuray Inc. announced recently that the Heidelberg University Hospital in Heidelberg, Germany, and Oscar Lambret...
RayStation Selected for New Carbon Ion Therapy Center in Japan
News | Treatment Planning | January 18, 2018
January 18, 2018 – RayStation has been chosen as the treatment planning system for a new carbon-ion therapy facility
Raysearch Receives First Order for the Raycare Oncology Information System
News | Oncology Information Management Systems (OIMS) | January 18, 2018
January 18, 2018 – Anderson Regional Cancer Center (ARCC) in Meridian, Mississippi, has placed the first order for...
Transpara Deep Learning Software Matches Experienced Radiologists in Mammogram Reading
News | Computer-Aided Detection Software | January 12, 2018
Deep learning and artificial intelligence improves the efficiency and accuracy of reading mammograms, according to...
Fat Distribution in Women and Men Provides Clues to Heart Attack Risk
News | Women's Health | January 11, 2018
January 11, 2018 – It’s not the amount of fat in your body but where it is stored that may increase your risk for hea
Women Prefer Getting Mammograms Every Year
News | Mammography | January 09, 2018
Women prefer to get their mammograms every year, instead of every two years, according to a new study presented at the...
Planmed Clarity 2-D Digital Mammography System Receives FDA Approval
Technology | Mammography | January 08, 2018
The U.S. Food and Drug Administration (FDA) issued an approval letter for the Planmed Clarity 2-D full-field digital...
Overweight Women May Need More Frequent Mammograms
News | Mammography | January 04, 2018
Women with higher body mass index (BMI) face an increased risk of not detecting their breast tumor until it has become...
Mevion Receives 510(k) Clearance for Hyperscan Pencil Beam Scanning Proton Therapy
Technology | Proton Therapy | January 04, 2018
Mevion Medical Systems has received U.S. Food and Drug Administration (FDA) 510(k) clearance for the Mevion S250i...
Overlay Init