News | June 09, 2010

Single Dose IORT for Breast Tumors Found Effective

Intraoperative Radiotherapy (IORT) is used for accelerated, partial breast irradiation.

June 9, 2010 - A single radiation dose during intraoperative radiotherapy (IORT) is at least as effective as longer post-operative treatments, according to results from a study presented at the American Society of Clinical Oncology (ASCO) meeting, held June 4-8 in Chicago and published in the Lancet June 5.

In the study, TARGIT (targeted intraoperative radiotherapy), the radiation therapy is confined to the area of the breast where the tumor has been removed. Researchers reported that TARGIT is as effective at preventing breast cancer recurrence as whole breast radiotherapy and can be completed in one hospital visit.

After surgery to conserve the breast, 90 percent of cancer recurrences occur very near to where the removed tumor was (index quadrant), despite the presence of multicentric cancers elsewhere in the breast. Researchers suggested restriction of radiation therapy to the site of the tumor bed during surgery may be suitable for selected patients. The authors compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

The trial enrolled women aged at least 45 years with invasive ductal breast carcinoma undergoing breast-conserving surgery were enrolled.

A total of 1,113 patients were randomly allocated to targeted intraoperative radiotherapy and 1,119 were allocated to external beam radiotherapy.

Of 996 patients who received the allocated treatment in the targeted intraoperative radiotherapy group:

- 854 (86 percent) received targeted intraoperative radiotherapy only
- 142 (14 percent) received targeted intraoperative radiotherapy plus external beam radiotherapy

There were 1,025 (92 percent) patients in the external beam radiotherapy group received the allocated treatment.

At four years, there were:

- Six local recurrences (of cancer) in the intraoperative radiotherapy group
- Five local recurrences (of cancer) in the external beam radiotherapy group

Occurrence rates in the two groups were similar; 1-20 percent in the targeted intraoperative radiotherapy and 0-95 percent in the external beam radiotherapy group.

The researchers found targeted intraoperative radiotherapy almost completely avoids irradiation of the intrathoracic structures such as the heart, lung, and oesophagus. Consequently, the damage to these structures, which can occur even with modern external beam radiotherapy, will have been avoided.

They wrote in their conclusion: "For selected patients with early breast cancer, a single dose of radiotherapy delivered at the time of surgery by use of targeted intraoperative radiotherapy should be considered as an alternative to external beam radiotherapy delivered over several weeks."

Reference: Vaidya, J., et al. "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, noninferiority phase 3 trial." The Lancet. June 5, 2010. DOI:10.1016/S0140-6736(10)60837-9

For more information:

Related Content

Hologic Opens Learning and Experience Centre in Zaventem, Belgium
News | Women's Health | March 21, 2019
Hologic Inc. opened its first Learning and Experience Centre in Zaventem, Belgium. The state-of-the-art facility...
QTbreasthealth Opens Breast Imaging Center in San Jose
News | Ultrasound Women's Health | March 20, 2019
QTbreasthealth has opened a new center in San Jose, Calif. The new location is now open and booking appointments for...
ZON-PTC in Clinical Use With RayStation 8B and Hyperscan
News | Treatment Planning | March 19, 2019
Zuid-Oost Nederland Protonen Therapie Centrum (ZON-PTC), Maastricht, Netherlands, recently treated its first patient...
Older Biologic Age Linked to Elevated Breast Cancer Risk
News | Women's Health | March 19, 2019
Biologic age, a DNA-based estimate of a person’s age, is associated with future development of breast cancer, according...
PET Scans Show Biomarkers Could Spare Some Breast Cancer Patients from Chemotherapy
News | PET Imaging | March 18, 2019
A new study positron emission tomography (PET) scans has identified a biomarker that may accurately predict which...
Fujifilm Launches Three New Software Tools for Aspire Cristalle Digital Mammography System
Technology | Mammography | March 15, 2019
Fujifilm Medical Systems USA announced it has fulfilled all U.S. Food and Drug Administration (FDA) regulatory...
Hologic Receives CE Mark for Three-in-One Omni Hysteroscope
News | Endoscopes | March 14, 2019
Hologic Inc. announced it has received a CE mark in Europe for its Omni hysteroscope, a three-in-one modular scope with...
What to Expect from the Proton Therapy Market in 2019-2020
News | Proton Therapy | March 13, 2019
The number of new particle therapy rooms ordered worldwide dropped by almost 20 percent in 2018, according to a new...
CT, Mammograms Offer Clues to Preventing Heart Problems After Cancer Treatment
News | Cardio-oncology | March 13, 2019
An imaging procedure commonly performed before starting cancer treatment can provide valuable clues about a patient's...