News | April 16, 2014

Researchers Find Treating Tumors with Radiotherapy First Makes Immunotherapy More Effective

April 16, 2014 — Researchers at Thomas Jefferson University have tested an experimental cancer vaccine in combination with radiation therapy in mice with colorectal cancer. In research published online in the International Journal of Radiation Oncology, they showed the vaccine was most effective when tumors were irradiated first and then vaccinated a week later.

Not only does radiation therapy force cancer cells to self-destruct, but several studies demonstrate that it also activates the immune system to attack tumor cells. This activation can be used to boost current immunotherapies, such as anti-tumor vaccines, to produce better clinical results. What's less clear, however, is exactly how to combine the two therapies to get the best bang for the therapeutic buck.

"Prior to these experiments, we didn't appreciate the impact that sequencing of these treatments had on their combined ability to generate immune and clinical responses," says Matthew Witek M.D., radiation oncologist at Thomas Jefferson University and first author of the study. "Remarkably, immune activation and tumor regression only occurred when radiation was given prior to vaccination."

When mice received either treatment alone, the researchers noticed only a modest reduction in tumor size. However, when radiation was given first, the investigators saw a six-fold increase in cancer-fighting immune cells, and impressively, complete remission of the majority of tumors.

Although the work will need to be reproduced in humans to determine if the same holds true for cancer patients, the finding is exciting, says lead researcher Adam Snook, Ph.D., an instructor in the department of pharmacology and experimental therapeutics. "In a patient population that will undergo radiation therapy as standard treatment, these results provide a roadmap to amplifying the effects of immunotherapies like the one we're developing for colon cancer."

Targeted Diagnostics & Therapeutics Inc, which provided research funding that in part supported this work, has a license to commercialize inventions related to this work. The authors reported no other conflict of interest.

For more information: www.jefferson.edu

Related Content

DOSIsoft Releases ISOgray Proton Therapy Treatment Planning System
Technology | Treatment Planning | August 15, 2017
DOSIsoft SA announced the official release, with CE marking, of ISOgray Treatment Planning System (TPS) release 4.3 for...
First Radixact Results Presented at AAPM 2017
News | Radiation Therapy | August 10, 2017
Accuray Inc. announced that the first studies validating the benefits of the Radixact System were presented at the 59th...
Clinical Data Supports Use of Xoft System for Endometrial Cancer
News | Brachytherapy Systems | August 03, 2017
Researchers presented clinical data supporting use of the Xoft Axxent Electronic Brachytherapy (eBx) System for the...
Aktina’s interchangeable cones are lightweight and extremely accurate
News | Radiation Therapy | August 02, 2017
Aktina Medical announced a collaboration with Philips Medical Systems and Elekta Instruments for SRS interlocking at...
News | Image Guided Radiation Therapy (IGRT) | July 31, 2017
Elekta’s magnetic resonance radiation therapy (MR/RT) system will be the subject of 21 abstracts at the 59th American...
Accuray Receives 510(k) Clearance for iDMS Data Management System
Technology | Oncology Information Management Systems (OIMS) | July 31, 2017
July 31, 2017 — Accuray Inc. announced it has received 510(k) clearance from the U.S.
more healthcare providers and patients are choosing options such as Gamma Knife stereotactic radiosurgery
News | Radiation Therapy | July 31, 2017
Each year, up to 650,000 people who were previously diagnosed with various forms of cancer will develop brain...
Radiotherapy Prior to Surgery Reduces Secondary Tumor Risk in Early-Stage Breast Cancer Patients
News | Radiation Therapy | July 24, 2017
Moffitt Cancer Center researchers launched a first-of-its-kind study comparing the long-term benefits of radiation...
Overlay Init