News | May 29, 2015

Public-Private Partnership Restarting Mo-99 Production in U.S.

Cooperative R&D agreement will develop scalable standalone system for domestic production

May 29, 2015 — National Security Technologies LLC (NSTec) and Henderson, Nevada-based Global Medical Isotope Systems (GMIS) announced a public-private partnership agreement for research and development of an essential radioactive isotope used in millions of medical diagnostic imaging procedures annually.

Known primarily as the management and operations contractor for the Nevada National Security Site (NNSS), NSTec is leveraging its traditional national security role with the signing of its first cooperative research and development agreement (CRADA). The agreement describes NSTec's technical integration, modeling, materials and design support to GMIS's mission in the development and deployment of a ground-breaking approach to the production of the radioactive isotope molybdenum-99 (Mo-99).

By introducing a safe, decentralized, on-demand production system using non-enriched uranium, the two companies are answering a critical supply need of the medical imaging community. The United States terminated its domestic Mo-99 production in the 1990s, but continues to import the isotope from Canada and Europe. In addition, U.S. and global demand for Mo-99 has grown substantially in recent years, making easy and timely access to supplies of the isotope more important than ever.

The imaging isotope Technetium-99m (Tc-99m) is a decay by-product of Mo-99, and has a half-life of only about 6 hours. This unique physical characteristic makes Tc-99m the most widely used medical diagnostic isotope in nuclear medicine. Its short half-life allows it to be used in body-scanning procedures that collect data rapidly, but keeps total patient radiation exposure low — but it also makes keeping an inventory next to impossible. 

Presently, there are about 40 million imaging and diagnostic procedures performed worldwide per year, of which 80-85 percent use Tc-99m. Of those 40 million, more than 20 million are performed in North America, about 1.5 million in Canada, and approximately 15,000 in southern Nevada.

GMIS is currently developing a scalable standalone system to produce the isotope, allowing for custom deployments to other areas of the country.

The five-year CRADA calls for NSTec to provide technical integration, modeling, materials, and design support to GMIS's mission.  

NSTec also brings to the CRADA a staff of nuclear and health physicists, skilled physics and electronics technicians, a variety of radiological materials, and an extensive inventory of radiation detection equipment.

For more information: www.nstec.com

Related Content

PET Tracer Gauges Effectiveness of Promising Alzheimer's Treatment

Longitudinal PET imaging with 18F-AV45. PET imaging shows the average 18F-AV45 uptake per animal group at 8 and 13 months of age. A significant interaction of genotype treatment was observed in the cortex (p = 0.0248), hippocampus (p = 0.0071) and thalamus (p = 0.0084), indicating reduced [18F]-AV45 uptake in BACE1 inhibited transgenic mice. Credit: MICA, University of Antwerp, Belgium.

News | Radiopharmaceuticals and Tracers | December 28, 2017
In the December featured basic science article in The Journal of Nuclear Medicine, Belgian researchers report on the...
Vital Unveils Newest Vitrea Advanced Visualization Release at RSNA 2017
Technology | Advanced Visualization | December 04, 2017
Vital Images unveiled the newest version of Vitrea Advanced Visualization software, the cornerstone of its imaging...
Michael J. Fox Foundation and Tau Consortium Developing PET Tracers for Neurodegenerative Disease
News | Radiopharmaceuticals and Tracers | October 27, 2017
The Michael J. Fox Foundation for Parkinson's Research (MJFF) and the Tau Consortium announced a funding partnership to...
Netherlands Cancer Institute Exploring Molecular Imaging Technology for Prostate Cancer Surgery
News | Molecular Imaging | October 26, 2017
The Netherlands Cancer Institute (NKI) announced it has received funding from the Dutch Cancer Society (KWF...
SNMMI Publishes New FDG PET/CT Appropriate Use Criteria
News | PET-CT | October 25, 2017
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has published appropriate use criteria (AUC) for FDG PET/...
Biodex Unveils Atomlab 500 Dose Calibrator and Wipe Test Counter
Technology | Nuclear Imaging | October 19, 2017
Biodex Medical Systems announced the full release of the Atomlab Dose Calibrator and Wipe Test Counter to the market...
ASNC and ASE Team Up to Expand ImageGuide Registry
News | Cardiovascular Ultrasound | October 12, 2017
The American Society of Nuclear Cardiology (ASNC) and the American Society of Echocardiography (ASE) jointly announced...
MR Solutions Showcases Multimodality MRI Solutions on Two Continents
News | Magnetic Resonance Imaging (MRI) | October 11, 2017
October 11, 2017 — MR Solutions took their cryogen-free preclinical multimodality...
Majority of Recurrent Prostate Cancer Patients' Treatment Plan Changed Following Fluciclovine 18F PET/CT
News | Prostate Cancer | October 04, 2017
Blue Earth Diagnostics recently announced the results of a pre-planned interim analysis from an investigational...
News | Business | September 19, 2017
September 19, 2017 — Invicro LLC, a provider of imaging services and software for research and drug development, anno
Overlay Init