News | March 17, 2010

PEM Proved Better than Breast MRI for PPV

March 17, 2010 - New data from an NIH-sponsored, multi-site study showed the positron emission mammography (PEM) had 31 fewer unnecessary biopsies and 26 percent higher positive predictive value (PPV) than breast MR. Researchers said this may reduce unnecessary breast biopsies.

The study found that PEM had a significantly more PPV, therefore reducing the number of unnecessary biopsies. The 388 woman study showed that PEM not only demonstrated a six percent improvement in specificity at comparably high sensitivity, but that PEM also had 31 fewer unnecessary biopsies and 26 percent higher PPV than breast MR. These results are also particularly significant for those women who cannot tolerate an MR exam and require an alternate imaging tool.

Wendie Berg, M.D., Ph.D. and principal investigator for the trial, said PEM was a legitimate and better alternative for the 16 percent of women who cannot tolerate MR due to claustrophobia, metallic implants, body habitus, or gadolinium reaction.

PEM scanners are high-resolution breast PET systems that can show the location as well as the metabolic phase of a lesion. This information is critical in determining whether a lesion is malignant and influences the course of treatment. Other imaging systems, such as mammography and ultrasound, show only the location, not the metabolic phase.

The NIH-sponsored multi-site study (NIH Grant 5R44CA103102) examined women with newly-diagnosed breast cancer. Patients were accrued from six leading clinical centers across the country: ARS Johns Hopkins Green Spring, Boca Raton Community Hospital, Scripps Clinic-Scripps Green Hospital, University of North Carolina, University of Southern California Norris Cancer Center, and Anne Arundel Medical Center.

Related Content

Cianna Medical featured its wire-free marker system on the exhibit floor of the breast imaging symposium in Hollywood, Fla.

Cianna Medical featured its wire-free marker system on the exhibit floor of the breast imaging symposium in Hollywood, Fla.

Feature | Breast Imaging | April 24, 2019 | By Greg Freiherr
Wires have traditionally been placed prior to lumpectomy to mark cancerous tissues in the breast.
GE Healthcare showcases Senographe Pristina with its add-on-biopsy kit at the breast imaging symposium

GE Healthcare showcases Senographe Pristina with its add-on-biopsy kit at the breast imaging symposium in Hollywood, Florida. Photo by Greg Freiherr

Feature | Breast Imaging | April 23, 2019 | By Greg Freiherr
Signs of what the future may look like in women’s health dotted the exhibit floor of the...
Videos | Breast Imaging | April 18, 2019
In a keynote lecture at the Society of Breast Imaging (SBI)/American College of Radiology (ACR) 2019 Symposium, ...
Fatty tissue and breast density may be considered in the context of many factors that affect the occurrence and detection of breast cancer

Fatty tissue and breast density may be considered in the context of many factors that affect the occurrence and detection of breast cancer. Permission to publish provided by DenseBreast-info.org

Feature | Breast Imaging | April 18, 2019 | By Greg Freiherr
When planning a screening program to detect the early signs of breast cancer, age is a major consideration.
compressed breast during mammography.
360 Photos | 360 View Photos | April 16, 2019
A 360 view of a simulated breast compression for a...
A smart algorithm has been trained on a neural network to recognize the appearance of breast cancer in MR images

A smart algorithm has been trained on a neural network to recognize the appearance of breast cancer in MR images. The algorithm, described at the SBI/ACR Breast Imaging Symposium, used “Deep Learning,“ a form of machine learning, which is a type of artificial intelligence. Graphic courtesy of Sarah Eskreis-Winkler, M.D.

Feature | Artificial Intelligence | April 12, 2019 | By Greg Freiherr
The use of smart algorithms has the potential to make healthcare more efficient.
This image depicts ABUS images with QVCAD results

This image depicts ABUS images with QVCAD results.

Feature | Breast Imaging | April 12, 2019
Imaging Technology News spoke with Bob Foley, vice president of sales and marketing of QView Medical, Inc.,
Visage 7 Enterprise Imaging Platform Highlighted at 2019 SBI/ACR Breast Imaging Symposium
News | Enterprise Imaging | April 05, 2019
Visage Imaging will be exhibiting the latest version of the Visage 7 Enterprise Imaging Platform at the 2019 Society of...