News | October 15, 2008

NIH Gives $11 Million to MRI Research for Neurodegenerative Disorders, Proteomics

October 16, 2008 - The National Center for Research Resources (NCRR), a part of the National Institutes of Health (NIH), announced it will provide up to an estimated $11 million over the next five years to research on imaging techniques designed specifically to better diagnose and treat diseases and analyzing sets of interacting proteins.

NIH will fund studies at two new Biomedical Technology Research Centers (BTRCs) with access to specialized research tools. One center will develop innovative imaging techniques using magnetic resonance imaging (MRI) designed specifically to better diagnose and treat diseases, such as Alzheimer’s, where the nervous system progressively deteriorates. A second center will create cutting-edge software for identifying and analyzing sets of interacting proteins that are important in a wide range of diseases, such as cancer.

Each center creates critical and often unique technology to apply to a broad range of basic, clinical and translational research. Serving as test beds for solving complex biomedical research problems, BTRC research projects combine the expertise of multidisciplinary technical and biomedical experts both within the center and through collaborative partnerships. These efforts result in innovative solutions to today’s health challenges, which are then actively disseminated to promote rapid adoption and achieve the broadest possible impact.

The new centers are being established at the Northern California Institute for Research and Education Inc. in San Francisco and at the University of California, San Diego.

The Northern California Institute for Research and Education Inc. in San Francisco will receive a five-year award up to an estimated $6.04 million to develop a center for magnetic resonance imaging (MRI) of neurodegenerative disorders. This BTRC will develop innovative and improved MRI techniques for clinicians to better understand, detect, diagnose, and treat diseases, such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease.
The advanced techniques developed at the new center will offer researchers and clinicians improved image clarity, more reliable and precise methods for capturing anatomical data, more efficient and accurate reconstruction methods, and improved image processing capabilities.

Through a second BTRC award to the University of California, San Diego, totaling up to an estimated $4.94 million over five years, NCRR will support a new center for computational mass spectrometry that will serve as an international resource in proteomics, enabling more research activities, investigation into unexplored areas of computational proteomics, and support of collaborative research efforts. The goal of a proteomics experiment is often to identify thousands of proteins present in a complex biological sample, and detect differences in the amounts or structures of these proteins when samples are compared (e.g., a tumor vs. normal tissue). Looking at these differences and how they relate to one another can help shed light on the causes or progression of a disease and how drugs might be able to treat the disease.

The complex data generated in these experiments require sophisticated computational tools for interpretation. These tools have lagged behind the rapid evolution of new analytical technologies for proteomics. This new center will bring creative mathematical approaches to mass spectrometry and will build a new generation of reliable open-access software tools that will catalyze exchange and collaboration among experimental and computational researchers in proteomics, furthering advances in this critical field of research. The center will also focus on training the scientific community in the use of the technologies it develops.

For more information: www.ncrr.nih.gov/btrr/2008 and www.ncrr.nih.gov/btrr, www.ncrr.nih.gov and www.nih.gov

Related Content

Houston Methodist Hospital Enters Multi-Year Technology and Research Agreement With Siemens Healthineers
News | Imaging | August 17, 2017
Houston Methodist Hospital and Siemens Healthineers have entered into a multi-year agreement to bring cutting-edge...
Carestream Launches MR Brain Perfusion and Diffusion Modules for Vue PACS
Technology | Advanced Visualization | August 16, 2017
Carestream Health recently introduced new MR (magnetic resonance) Brain Perfusion and MR Brain Diffusion modules that...
ISMRM Issues Guidelines for MRI Gadolinium Contrast Agents
News | Contrast Media | August 15, 2017
The International Society for Magnetic Resonance in Medicine (ISMRM) has provided new guidance in the use of contrast...
MRI Reveals Striking Brain Differences in People with Genetic Autism

Example images for a control participant , a deletion carrier, and a duplication carrier. In the sagittal image of the deletion carrier, the thick corpus callosum, dens and craniocervical abnormality, and cerebellar ectopia are shown. For the duplication carrier, the sagittal image shows the thin corpus callosum and the axial image shows the increased ventricle size and decreased white matter volume. Image courtesy of the Radiological Society of North America (RSNA).

News | Neuro Imaging | August 09, 2017
August 9, 2017 — In the first major study of its kind, researchers using magnetic...
GE Healthcare's Signa Premier MRI Receives FDA 510(k) Clearance
Technology | Magnetic Resonance Imaging (MRI) | August 04, 2017
GE Healthcare announced Signa Premier, a new wide bore 3.0T magnetic resonance imaging (MRI) system, is now available...
brain with chronic traumatic injury
News | Magnetic Resonance Imaging (MRI) | August 02, 2017
Fighters are exposed to repeated mild traumatic brain injury (mTBI), which has been associated with neurodegenerative...
News | Image Guided Radiation Therapy (IGRT) | July 31, 2017
Elekta’s magnetic resonance radiation therapy (MR/RT) system will be the subject of 21 abstracts at the 59th American...
NIH-funded scientists have discovered that Parkinson’s disease increases the amount of “free” water in a particular brain area

NIH-funded scientists have discovered that Parkinson’s disease increases the amount of “free” water in a particular brain area. Image courtesy of David Vaillancourt, Ph.D., University of Florida.

News | Neuro Imaging | July 31, 2017
Scientists at the University of Florida have discovered a new method of observing the brain changes caused by Parkinson...
Overlay Init