News | July 28, 2008

New Technique Estimates Lung Tumor Changes

July 29, 2008 - Lung cancer presents a special challenge to clinicians attempting to evaluate the effectiveness of radiation treatment and determine the total dose of radiation received by the tumor and surrounding tissues.

The reason is simple: lung tumors change position as an individual breathes during medical scans. This unavoidable movement of the lungs makes it difficult to accurately assess tumor volume (particularly in the very small malignant nodules that are more treatable if detected early) and track any changes in size that may have resulted from treatment.

Issam M. El Naqa, an assistant professor of radiation oncology at Washington University in St. Louis, and his colleagues have devised a novel solution. Their semi-automated system combines two types of computer algorithms previously only used separately to process data from computerized tomography (CT) scans of the lungs.

So-called deformable regression algorithms are used to create a consistent set of coordinates on which tumor position and size can be mapped over the course of treatment, and segmentation algorithms allow tumors to be precisely located and distinguished from other lung tissue (or "segmented") in CT images. El Naqa and his colleagues, realizing that "both approaches could significantly benefit from the results of the other algorithm if coupled in the same framework," created a new program that does just that.

El Naqa, who has tested the combination algorithm in a preliminary study of four people with non-small cell lung cancer, says that the method provides more accurate and consistent results for tracking tumor changes. He says the technique "would allow us to learn more about tumor response to treatment and potentially be used in treatment adaptation," or, perhaps, in the pre-planning of treatment strategies that would reduce the overall levels of toxic radiation received by people undergoing radiotherapy for lung cancer.

For more information:

Source: American Association of Physicists in Medicine

Related Content

Merit Medical Completes Acquisition of Cianna Medical
News | Women's Health | November 14, 2018
Disposable device manufacturer Merit Medical Systems Inc. announced the closing of a definitive merger agreement to...
Videos | ASTRO | November 08, 2018
ITN Editor Dave Fornell took a tour of some of the most innovative technologies on display on the expo floor at the 
The Fujifilm FCT Embrace CT System displayed for the first time at ASTRO 2018.
360 Photos | 360 View Photos | November 07, 2018
Fujifilm's first FDA-cleared compu...
This is the Siemens Magnetom Sola RT edition 1.5T MRI system optimized for radiation therapy displayed for the first time since gaining FDA clearance in 2018. It was displayed at the American Society for Radiotherapy and Oncology (ASTRO) 2018 annual meeting. Read more about this system at ASTRO 2018. #ASTRO18 #ASTRO2018
360 Photos | 360 View Photos | November 07, 2018
This is the Siemens Magnetom Sola RT edition 1.5T MRI system optimized for...
GE Healthcare Discovery RF Gen 2 system displayed at ASTRO 2018. It is a dedicated computed tomography (CT) scanner for radiation oncology
360 Photos | 360 View Photos | November 07, 2018
This is the GE Healthcare Discovery RF Gen 2 system displayed at the ...
Proton Therapy for Pediatric Brain Tumors Has Favorable Cognitive Outcomes
News | Proton Therapy | November 06, 2018
Proton therapy treatment for pediatric brain tumor patients is associated with better neurocognitive outcomes compared...
Videos | Radiation Oncology | November 06, 2018
Genomics can be used to assess a patient's radiosensitivity, which can be used to increase or decrease the radiation
150-Year-Old Drug Might Improve Radiation Therapy for Cancer
News | Radiation Therapy | November 02, 2018
November 2, 2018 — A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more