News | October 02, 2013

New Study Identifies Preferred Method to Assess Patient Reactions to Radiation Therapy

North Shore-LIJ Health System presented data at ASTRO's 55th Annual Meeting

radiation therapy clinical trial study north shore LIJ ASTRO

October 2, 2013 — The North Shore-LIJ Health System Department of Radiation Medicine presented a study to evaluate the reliability of different systems used by caregivers to assess toxicity for patients receiving radiation therapy at the 55th Annual Meeting of the American Society of Therapeutic Radiation Oncology (ASTRO).

Typically, a radiation oncologist and nurse using a formal grading scheme assess the severity of reactions to radiation therapy. Research conducted by North Shore-LIJ's radiation oncologists evaluated the reliability of these grading systems by independent caregivers.

The study assessed whether independent caregivers would assign the same grade to the same adverse reaction using a common grading scheme. Images of breasts that had undergone radiation in 30 breast cancer patients on skin care protocols were presented to radiation oncologists and nurses who were asked to assign grades independently based on their evaluation of the images and provide feedback explaining their choices. The assessments were then analyzed and the level of agreement among caregivers was determined using statistical methods.

As presented at ASTRO, the study determined that overall, there was a significantly better agreement in the assessments based on the use of the Common Terminology Criteria for Adverse Events (CTCAE) scale, which was developed by the National Cancer Institute to standardize the assignment of grades across various caregivers. Analysis of the comments provided by the caregivers revealed a reliance on assessment criteria that was not necessarily explicit in the grading definitions.

"Establishing the reliability of the scale used to assess adverse reactions among different caregivers is an important step to enhance uniformity and consistency of the care to our patients," said Ajay Kapur, Ph.D., lead author of the study and director of medical physics research and education in the North Shore-LIJ Department of Radiation Medicine. "The specific grading scheme used must demonstrate a high level of reliability amongst various caregivers."

For more information: www.northshorelij.com

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