News | December 30, 2014

Alternative imaging technique based on difference in electric conductivity of cancerous, normal tissue

These are internal, spatially mapped microwave tomography system generated electrical property distribution images of a cancer patient's left breast, taken somewhat into her therapy. Shown are permittivity and conductivity image sets (top and bottom image series, respectively) reconstructed at 1100 MHz. Each plane (i.e., p1 - p7) identifies a different location within system where the image was taken, and is relative to the chest wall. You can clearly see the breast outline and the features inside the breast relate to fibroglandular tissue inside the adipose tissue. This breast has undergone treatment and so most of the tumor has disappeared. Image courtesy of N.Epstein/U.Calgary

December 30, 2014 — A new study in the current issue of the journal Review of Scientific Instruments from AIP Publishing suggests a microwave imaging system may provide a better, cheaper and safer way to look for breast cancer.

Although currently available diagnostic screening systems for breast cancer like X-ray computed tomography (CT) and mammography are effective at detecting early signs of tumors, they are far from perfect,

subjecting patients to ionizing radiation and sometimes inflicting discomfort on women who are undergoing screening because of the compression of the breast that is required to produce diagnostically useful images.

Microwaves could provide an alternative for looking for the telltale signs of breast cancer, said Neil Epstein, a NSERC CREATE I3T postdoctoral fellow at the University of Calgary in Canada. Epstein and his colleagues—engineering professor Paul Meaney of Dartmouth College's Thayer School of Engineering; and Keith Paulsen, director of the Dartmouth Advanced Imaging Center and the Robert A. Pritzker Professor of Biomedical Engineering and Professor of Radiology at the Geisel School of Medicine at Dartmouth—describe just such a microwave imaging system in the study.

Microwave imaging relies upon the known differences in the so-called dielectric properties of cancerous tissue and normal tissue—that is, their ability to conduct electricity or sustain an electric field. In the technique, the breast is suspended in a liquid bath (but not compressed) and closely surrounded by an array of 16 antennae. Each antenna illuminates the breast individually with a very low power microwave signal, with approximately one one-thousandth the power of a cell phone, while the other 15 antennae receive the signals transmitted through the breast; this is repeated for all 16 antennae, providing data that can be used to produce a 3-D representation of the breast, including the location of both normal and cancerous tissue.

"The iterative image reconstruction algorithm computes what the dielectric property distribution must have been to generate the measured signal patterns," Epstein said. "It is quite similar to X-ray computed tomography, where the target is radiated from all of the surrounding directions and the data is synthesized to create an image of the internal structures."

Although microwave imaging systems cannot yet provide the spatial resolution of mammography, they offer better specificity, Epstein said. In other words, once tumors are localized, the microwave imaging systems may be more adept at identifying whether those tumors are benign or malignant—determinations now made through tissue biopsies.

"Researchers are realizing that this lack of specificity is a significant limitation for conventional imaging techniques and are looking for alternative ways to enhance it. Microwave imaging could fill this niche, possibly in combination with other modalities," he said.

For more information: www.rsi.aip.org

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