News | February 17, 2012

Latest Data Presented on 18F Amyloid Plaque Imaging Agent

Flutemetamol radiotracer images in normal patients and those with Alzheimers disease.

January 17, 2012 – Data presented at the 6th Annual Human Amyloid Imaging (HAI) meeting in Miami suggest that the investigational 18F imaging agent Flutemetamol could add value to current diagnostic tools used by physicians to evaluate neurodegenerative conditions like Alzheimer’s disease. Flutemetamol is a GE Healthcare positron emission tomography (PET) radiotracer in phase III development for the detection of beta amyloid plaques.

Data presented in two abstracts from a clinical trial of 18F Flutemetamol in patients with suspected normal pressure hydrocephalus (NPH), a progressive condition associated with dementia, gait abnormalities and urinary incontinence, undergoing shunt placement, correlated Flutemetamol uptake with histopathological tissue biopsies for beta amyloid in vivo. In a third abstract from another study, researchers correlated Flutemetamol uptake and structural magnetic resonance imaging (MRI) in healthy volunteers and patients with a clinical diagnosis of Alzheimer’s disease or mild cognitive impairment (MCI). Specifically:

  • Flutemetamol uptake demonstrated a strong concordance with histopathology in subjects with NPH independent of timing and sequence of examinations.
  • Flutemetamol PET uptake showed 100 percent sensitivity and specificity with histopathology in a selected subset of subjects with NPH.
  • In a subset of patients with MCI, increased Flutemetamol uptake and decreased hippocampal volume were seen in those with progressive MCI versus those with stable MCI.

“These results support the potential role of Flutemetamol in helping physicians detect amyloid deposits in the brain,” said Jonathan Allis, MI PET segment leader, GE Healthcare Medical Diagnostics. “The ability to detect amyloid deposits in the brain could enable physicians to make a more accurate and earlier diagnosis of Alzheimer’s disease.”

The accumulation of beta amyloid in the brain may play a role leading up to the degeneration of neurons and is one of several biomarkers implicated in the development of Alzheimer’s disease. Currently, Alzheimer’s disease is confirmed by histopathological identification of tissue biomarkers, including beta amyloid plaques, in post-mortem brain samples.  Targeted imaging agents are being studied to determine their ability to help physicians detect amyloid deposition in live humans.

For more information: www.gehealthcare.com

 

Related Content

PET/CT Changes Care for 59 Percent of Suspected Recurrent Prostate Cancer Cases
News | Prostate Cancer | June 13, 2018
A recently presented investigational clinical trial evaluated the impact of 18F fluciclovine positron emission...
Nuclear imaging scan showing very good tissue delineation. Scan performed on a Biograph Vision positron emission tomography/computed tomography (PET-CT) system from Siemens Healthineers.

Nuclear imaging scan showing very good tissue delineation. It offers crisp overall image quality and sharply delineates the muscle and fat planes, vertebral margins and end plates, billiary radicals, renal calyces, aortic wall and papillary muscles of the heart. Scan performed on a Biograph Vision positron emission tomography/computed tomography (PET-CT) system from Siemens Healthineers.

Technology | PET-CT | June 05, 2018
June 5, 2018 — The U.S.
Emerging Trends in Nuclear Medicine
Feature | Nuclear Imaging | June 04, 2018 | By Jeff Zagoudis
Nuclear imaging and its various modalities have long played an important role in the diagnosis and treatment of numer
PET Imaging Agent Could Provide Early Diagnosis of Rheumatoid Arthritis

Coronal 18F-FEDAC PET/CT section of a mouse with collagen-induced arthritis. (A) On day 23 and day 37, increased uptake is noted in the front and hind paws of this mouse with collagen-induced arthritis. (B) Predictive performance of day 23 18F-FEDAC uptake for the development of clinical arthritis. ROC = receiver operating characteristic; Sn = sensitivity; Sp = specificity. Credit: Seoul National University and Ewha Womans University, Seoul, South Korea

News | PET Imaging | May 17, 2018
A novel positron emission tomography (PET) tracer developed by Korean researchers can visualize joint inflammation and...
PET Imaging Shows Protein Clumping May Contribute to Heart Failure Development
News | PET Imaging | May 11, 2018
A team led by Johns Hopkins University Researchers has discovered that protein clumps appear to accumulate in the...
News | Radiopharmaceuticals and Tracers | May 09, 2018
Blue Earth Diagnostics signed an exclusive, worldwide agreement with Scintomics GmbH, Germany, a specialist in...
Novel PET Agent Could Help Guide Therapy for Brain Diseases

Rat brain 11C‐Me‐NB1 PET images (0‐60 min) superimposed on an MRI template. Credit: SD Krämer et al., ETH Zurich, Zurich, Switzerland

News | PET Imaging | April 10, 2018
Researchers have developed a new imaging agent that could help guide and assess treatments for people with various...
The Chalk River nuclear reactor license has been renewed, but will be decommissioned by 2028.

The Chalk River nuclear isotope reactor license has been renewed, but will be decommissioned by 2028. The reactor supplies about 50 percent of the world's supply of Tc99m.

Feature | Nuclear Imaging | April 02, 2018 | Dave Fornell
April 2, 2018 – The Canadian Nuclear Safety Commission (CNSC) announced March 29 that it renewed Canadian Nuclear Lab
The yellow in the anterolateral entorhinal cortex of the young brain indicates significant activity, something that is absent in the older brain.

This figure shows two different brains that are aligned to a common template space for comparison. The yellow in the anterolateral entorhinal cortex of the young brain indicates significant activity, something that is absent in the older brain. CREDIT: Zachariah Reagh

News | Nuclear Imaging | March 08, 2018
As we get older, it's not uncommon to experience "senior moments," in which we forget where we parked our car or call...
Overlay Init