Gamma Knife, RapidArc Equally Effective for Brain Metastases

February 25, 2016 — While two advanced radiosurgery approaches — Gamma Knife and RapidArc — offer different strengths, they are equally effective at eradicating cancer in the brain, say researchers at Sidney Kimmel Cancer Center, Philadelphia.

Their study, published online January 25 in Frontiers in Oncology, compared the two different devices in brain radiosurgery. Six patients, each with three or four brain metastases, were studied.

The Gamma Knife was slightly more effective than RapidArc at focusing the beam of radiation, thus limiting spread to normal tissue, and RapidArc offered much quicker treatment compared to the Gamma Knife, researchers said. Gamma Knife treatment usually take 60-100 minutes, about 3-5 times longer than RapidArc, they said.

“In the end, using one or the other doesn’t make a significant clinical difference and that is important to know because physicians and patients now know they have a choice of treatments,” said the study’s senior author, associate professor Wenyin Shi, M.D., Ph.D., co-director of the Jefferson Brain Tumor Program.

Understanding the benefits of advanced radiosurgery technology is essential because there has been, and will continue to be, an increase in cases of brain metastases — tumors that spread to the brain from cancer somewhere else in the body, said co-author Adam Dicker, M.D., Ph.D., chair and professor of radiation oncology, pharmacology and experimental therapeutics at the Sidney Kimmel Medical College at Thomas Jefferson University.

“As drug therapy for cancer becomes better at controlling systemic cancer, disease in the brain increases over time. The brain is a sanctuary for cancer — chemotherapies and targeted agents can’t reach the brain and the central nervous system because of the blood-brain barrier,” Dicker said. “The results are that a number of different cancers are now showing up in the brain.”

Radiosurgery delivers a focused dose of radiation on tumors in order to shrink or kill the cancer, while sparing normal brain tissue. The Gamma Knife, invented in Sweden, features a circular array of 201 beams of gamma radiation that meet at a single point. The downside of the treatment, which is very accurate, is that patients wear a helmet that is fixed to the skull, Shi said. The procedure can also take a long time, he said.

RapidArc radiation is a type of linear accelerator that emits high-energy X-rays (also known as photons). Very small beams with varying intensities are aimed at a tumor and then rotated around the patient. This results in attacking the target in a complete three-dimensional manner. A single treatment can take as little as 10-15 minutes.

Study co-authors include Haisong Liu, Ph.D.; David W. Andrews, M.D.; James J. Evans, M.D.; Maria Werner-Wasik, M.D.; and Yan Yu, Ph.D., MBA, from Thomas Jefferson University.

The study was funded by Sidney Kimmel Cancer Center and Varian Medical.

For more information: www.journal.frontiersin.org/journal/oncology