News | September 21, 2008

Early Aggressive Treatment Increases Survival for Many Brain Tumor Patients

September 22, 2008 - Early aggressive treatment with chemotherapy prior to radiotherapy may prolong survival for patients with anaplastic oligodendrogliomas according to new research from the Radiation Therapy Oncology Group (RTOG) presented at ASTRO 2008.

RTOG, an NCI-funded national clinical trials group, is a clinical research component of the American College of Radiology (ACR).

Longer-term results of an RTOG study show that administering chemotherapy prior to radiotherapy increased survival for oligodendroglioma patients. Progression-free survival also improved for those receiving the neoadjuvant chemotherapy, a benefit most evident in those whose tumors have deletions of chromosomes 1p and 19q.

“Our research, while providing some answers for patients with oligodendrogliomas, shows that longer follow-up and genetic profiles will be necessary to provide definitive answers for determining initial treatment strategies,” said Gregory Cairncross, M.D., of the University of Calgary Foothills Medical Centre in Calgary, Canada.

RTOG 9402, a phase III study, enrolled 299 anaplastic oligodendroglioma patients from July 1994 until March 2002 at 104 academic and community facilities in the U.S. and Canada. Patients were randomized to receive either standard radiotherapy alone or four cycles of neoadjuvant chemotherapy using procarbazine, lomustine, and vincristine followed by standard radiotherapy. The unadjusted estimated five-year overall survival rate for all patients entered on the study was slightly better for those who received neoadjuvant chemotherapy (49 vs. 46 percent). The adjusted five-year survival rate is significantly different favoring the experimental arm (hazard ratio = 0.66; 95 percent confidence interval (0.46, 0.95); p value = 0.02). For progression-free survival, the unadjusted estimated five-year rate for all patients entered on the study was significantly better for those who received neoadjuvant chemotherapy (37 vs. 22 percent; p value = 0.003). The adjusted five-year overall progression-free survival was also significantly different favoring the experimental arm (hazard ratio = 0.57; 95 percent confidence interval (0.41, 0.79); p value = 0.02).

Molecular analysis of oligodendrogliomas divides these tumors into two groups – those with deletion of both chromosomes 1p and 19q and those without. RTOG research has shown that patients with the deletions have a better response to treatment and overall survival. RTOG 9402 data reports that patients with the deletion had a median survival of 8.7 years vs. 2.7 years for those without the co-deletion (p

For more information:,

Related Content

DOSIsoft Releases ISOgray Proton Therapy Treatment Planning System
Technology | Treatment Planning | August 15, 2017
DOSIsoft SA announced the official release, with CE marking, of ISOgray Treatment Planning System (TPS) release 4.3 for...
First Radixact Results Presented at AAPM 2017
News | Radiation Therapy | August 10, 2017
Accuray Inc. announced that the first studies validating the benefits of the Radixact System were presented at the 59th...
Clinical Data Supports Use of Xoft System for Endometrial Cancer
News | Brachytherapy Systems | August 03, 2017
Researchers presented clinical data supporting use of the Xoft Axxent Electronic Brachytherapy (eBx) System for the...
Aktina’s interchangeable cones are lightweight and extremely accurate
News | Radiation Therapy | August 02, 2017
Aktina Medical announced a collaboration with Philips Medical Systems and Elekta Instruments for SRS interlocking at...
News | Image Guided Radiation Therapy (IGRT) | July 31, 2017
Elekta’s magnetic resonance radiation therapy (MR/RT) system will be the subject of 21 abstracts at the 59th American...
Accuray Receives 510(k) Clearance for iDMS Data Management System
Technology | Oncology Information Management Systems (OIMS) | July 31, 2017
July 31, 2017 — Accuray Inc. announced it has received 510(k) clearance from the U.S.
more healthcare providers and patients are choosing options such as Gamma Knife stereotactic radiosurgery
News | Radiation Therapy | July 31, 2017
Each year, up to 650,000 people who were previously diagnosed with various forms of cancer will develop brain...
Radiotherapy Prior to Surgery Reduces Secondary Tumor Risk in Early-Stage Breast Cancer Patients
News | Radiation Therapy | July 24, 2017
Moffitt Cancer Center researchers launched a first-of-its-kind study comparing the long-term benefits of radiation...
Overlay Init