News | November 20, 2008

Chemotherapy Added to Radiotherapy Improves Survival for Low Grade Glioma Patients

November 20, 2008 – Adult patients with low grade glioma, a type of malignant brain tumor, had a better chance for survival if they received chemotherapy in addition to their course of radiotherapy, according to new research from the Radiation Therapy Oncology Group (RTOG) presented at the Society for Neuro-Oncology 13th Annual Meeting in Lake Las Vegas, NV.

“In this RTOG study we found that patients who survived at least one year from the completion of their treatment had much better survival and progression-free survival rates if they received chemotherapy in combination with radiotherapy,” said lead author Edward G. Shaw, M.D., of the Wake Forest University School of Medicine, Winston-Salem, NC. “This is the first multi-center prospective clinical trial to suggest a benefit from adjuvant therapy in this patient population.”

The 251 patients enrolled on RTOG 9802 were entered from academic and community-based sites in the U.S. and Canada from 1998 until 2002. High-risk low-grade glioma patients were randomized to receive either six weeks of radiotherapy alone or six weeks of radiotherapy followed by six cycles of chemotherapy consisting of procarbazine, CCNU and vincristine. RTOG found that for patients who survived at least one year post treatment, the risk of death was reduced by 43 percent and progression-free survival was reduced by 64 percent. With a median follow-up of 5.9 years, the overall five-year survival rate was 72 percent for the patients who received the additional chemotherapy as compared to 63 percent for those who received radiotherapy alone. The five-year progression-free survival rates were 63 percent versus 46 percent.

“There are a number of controversial issues in the management of low-grade gliomas, including which patients benefit from adjuvant therapy, and RTOG is one of the few groups that is able to study this patient population in a prospective manner,” said Walter J. Curran, Jr., the RTOG group chair, and the Lawrence W. Davis Professor and chair of the Department of Radiation Oncology in the Emory School of Medicine and Chief Medical Officer of the Emory Winship Cancer Institute. “With two-thirds of the patients still alive at five years we look forward to the long-term follow-up results for this study as well as analysis of the 1p19q genetic codeletion data.”

RTOG is a National Cancer Institute-funded national clinical trials group and is administered by the American College of Radiology.

For more information: www.rtog.org

Related Content

New Prostate Cancer Radiotherapy Technique Aims to Preserve Sexual Function
News | Radiation Therapy | June 18, 2018
A multicenter clinical trial being led by UT Southwestern physicians is testing a technique for sparing nerve bundles...
Elekta Unity High-Field MR-Linac Receives CE Mark
News | Image Guided Radiation Therapy (IGRT) | June 18, 2018
Elekta announced that its Elekta Unity magnetic resonance radiation therapy (MR/RT) system has received CE mark,...
Washington University in St. Louis Begins Clinical Treatments With ViewRay MRIdian Linac
News | Image Guided Radiation Therapy (IGRT) | June 14, 2018
June 14, 2018 — The Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in S
Accuray TomoTherapy System Beneficial in Two Total Body Irradiation Studies
News | Radiation Therapy | June 13, 2018
Recently published data from two new studies demonstrate the benefits of Accuray’s TomoTherapy System in the delivery...
IsoRay Funding Brain Cancer Treatment Research With Ochsner Clinic Foundation
News | Brachytherapy Systems | June 12, 2018
IsoRay Inc. announced the initiation of research funding for brain cancer treatment to Ochsner Clinic Foundation, a not...
News | Brachytherapy Systems | June 07, 2018
IsoRay Inc. announced the upcoming release of its Build-Blu delivery system for real-time prostate brachytherapy.
Raysearch RayStation
Feature | Radiation Therapy | June 05, 2018 | By Melinda Taschetta-Millane
Treatment planning systems are at the heart of r...
Lung Decision Precision
News | Lung Cancer | June 04, 2018
For smokers and former smokers, the threat of lung cancer always lurks in the shadows.
Beaumont Researchers Invent New Mode of Proton Treatment for Lung Cancer
News | Proton Therapy | May 31, 2018
Members of Beaumont Health’s proton therapy team presented research on a new treatment for patients with lung cancer at...
More Than 60 Percent of Patients Seeking Proton Therapy Initially Denied Coverage
News | Proton Therapy | May 25, 2018
The Alliance for Proton Therapy Access has released a national report revealing the heavy emotional and financial...
Overlay Init