News | December 26, 2014

Cancer Therapy Shows Promise for Nuclear Medicine Treatment

Targeted therapy with radiopharmaceuticals has great potential for the treatment of cancer

targeted radiation therapy, radiopharmaceuticals, nuclear medicine treatment

Photo courtesy of iStock

December 26, 2014 – Cancer therapy can be much more effective using a new way to customize nuclear medicine treatment, researchers say in the December 2014 issue of The Journal of Nuclear Medicine. The process could also be useful for other diseases that could benefit from targeted radiation

Targeted therapy with radiopharmaceuticals has great potential for the treatment of cancer, especially for cancer cells that have migrated from primary tumors to lymph nodes and secondary organs such as bone marrow. These disseminated tumor cells can be difficult to treat with a single targeting agent because there are dramatic differences in the number of targetable receptors on each cell. 

In the study, breast cancer cells were treated with different concentrations of a cocktail of four fluorochrome-conjugated monoclonal antibodies. The amount of each antibody bound to each cell was determined using flow cytometry. Formulas were developed to “arm” the antibodies with the desired radionuclide and activity, calculate the absorbed dose to each cell, and perform a simulation of the surviving fraction of cells after exposure to cocktails of different antibody combinations. Simulations were performed for three alpha-particle emitters. 

“Our approach moves radiation treatment planning for cancer therapy from the tumor level to the molecular and cellular level, with nuclear medicine serving as the treatment engine,” stated Roger Howell, Ph.D., lead researcher. “The concepts are not restricted to cancer therapy but can be applied more widely to other diseases that may benefit from a targeted approach with cocktails of radiopharmaceuticals. The approach can also be extended to cocktails consisting of radiopharmaceuticals and non-radioactive agents.”

The effect of the radiopharmaceutical cocktails was compared to that of single antibodies. In certain activities, cocktails outperformed single antibodies by a factor of up to 244. These findings suggest that targeted alpha therapy can be improved with customized radiolabeled antibody cocktails. Depending on the antibody combination and specific activity of the radiolabeled antibodies, cocktails can provide a substantial advantage in tumor cell killing. The methodology used in this analysis provides a foundation for pretreatment prediction of tumor cell survival in the context of personalized cancer therapy.

For more information: jnm.snmjournals.org

Related Content

First Hospitals Achieve Inter-System Connectivity Across Accuray Radiation Therapy Platforms
News | Radiation Therapy | January 19, 2018
Accuray Inc. announced recently that the Heidelberg University Hospital in Heidelberg, Germany, and Oscar Lambret...
RayStation Selected for New Carbon Ion Therapy Center in Japan
News | Treatment Planning | January 18, 2018
January 18, 2018 – RayStation has been chosen as the treatment planning system for a new carbon-ion therapy facility
Raysearch Receives First Order for the Raycare Oncology Information System
News | Oncology Information Management Systems (OIMS) | January 18, 2018
January 18, 2018 – Anderson Regional Cancer Center (ARCC) in Meridian, Mississippi, has placed the first order for...
Transpara Deep Learning Software Matches Experienced Radiologists in Mammogram Reading
News | Computer-Aided Detection Software | January 12, 2018
Deep learning and artificial intelligence improves the efficiency and accuracy of reading mammograms, according to...
Smartphone Addiction Creates Imbalance in Brain
News | Mobile Devices | January 11, 2018
Researchers have found an imbalance in the brain chemistry of young people addicted to smartphones and the internet,...
Fat Distribution in Women and Men Provides Clues to Heart Attack Risk
News | Women's Health | January 11, 2018
January 11, 2018 – It’s not the amount of fat in your body but where it is stored that may increase your risk for hea
Minimally Invasive Treatment Provides Relief from Back Pain

Lumbar spine MRI showing disc herniation and nerve root at baseline and one month after treatment

News | Interventional Radiology | January 11, 2018
The majority of patients were pain free after receiving a new image-guided pulsed radiofrequency treatment for low back...
Emergency Radiologists See Inner Toll of Opioid Use Disorders

Rates of Imaging Positivity for IV-SUDs Complications. Image courtesy of Efren J. Flores, M.D.

News | Clinical Study | January 11, 2018
January 11, 2018 – Emergency radiologists are seeing a high prevalence of patients with complications related to opio
CT Shows Enlarged Aortas in Former Pro Football Players

3-D rendering from a cardiac CT dataset demonstrating mild dilation of the ascending aorta.

News | Computed Tomography (CT) | January 11, 2018
Former National Football League (NFL) players are more likely to have enlarged aortas, a condition that may put them at...
Overlay Init