April 12, 2013 — Aspect Imaging launched LumiQuant, its software and hardware solution for co-registering and measuring luminescence imaging images with the Bruker Icon compact high-performance magnetic resonance imaging (MRI) system. The LumiQuant solution enables researchers to generate 3-D luminescence data co-registered with MRI, a path forward in multi-modal tomographic imaging.
LumiQuant leverages a multi-modality cassette that allows a mouse to be imaged in an optical instrument and then moved and imaged in the Bruker Icon compact MRI without perturbation. The image reconstruction and co-registration package uses a proprietary set of algorithms to create a three-dimensional distribution of luminescence signal.
Luminescence, which is the most widely used pre-clinical in vivo imaging modality for assessing pre-clinical disease models, suffers from the physical constraints of the absorption and scattering of light in tissues. This absorption and scattering hinders the ability of luminescence systems to differentiate between luminescence signal in different organs and on the surface or signal deep within the tissue and therefore limits the researcher's ability to tell whether a luminescence-expressing tumor, for example, is on the surface, is deep in the organ, is a single tumor mass or possibly is the signal expressed from multiple lesions at different positions in the body. LumiQuant seeks to resolve this obstacle through enhanced insights and quantitation of 3-D luminescence/MR imaging and disease phenotyping.