News | April 20, 2008

Advanced MRI Studies Shed New Light On Early Parkinson's Disease


April 21, 2008 - Using advanced magnetic resonance imaging (MRI) technologies available at the Buffalo Neuroimaging Analysis Center (BNAC), researchers have been able to identify brain regions linked to Parkinson's disease based on images showing the status of both white and grey matter, according to two studies from the University at Buffalo presented at the 2008 American Academy of Neurology meeting in Chicago.

The work is the result of a joint project by neurology and imaging specialists from UB, Stavanger University Hospital and University of Bergen, both in Norway.

Turi O. Dalaker, M.D., a doctoral fellow from Stavanger University Hospital who conducted the research in the Buffalo Neuroimaging Analysis Center (BNAC), is first author on both studies. The BNAC, housed in Kaleida Health's Buffalo General Hospital, is part of the Jacobs Neurological Institute, the Department of Neurology in the UB School of Medicine and Biomedical Sciences.

One study, a case-control investigation, compared brain MRI scans and scores on the Mini-Mental State Examination (MMSE), a standard mental screening test, of 155 patients diagnosed with early Parkinson's disease with those of 101 normal subjects.

This study describes one of the first large-scale analyses of the extent of global (overall), tissue-specific and regional brain atrophy, and white matter hyperintensities (WMH). WMH are diseased areas of the white matter seen commonly in brain MRI scans in the elderly.

Results showed that in Parkinson's patients, white matter hyperintensities were associated significantly with lower scores on the mental test: The more areas of hyperintensity, the lower the MMSE score.

The second study examined whether mild cognitive impairment in early PD is associated with atrophy of a specific brain region. The researchers were interested also in investigating the possible link between mild cognitive impairment in PD and a higher risk of developing dementia.

Applying an MRI analytical process called voxel-based morphology, Dalaker and colleagues analyzed high-resolution MRI scans of 43 newly diagnosed PD patients and those of 31 sex-matched normal controls.

They found that the PD patients with mild cognitive impairment showed a trend toward reduced grey matter in the cingulate area, a brain region associated with cognitive performance.

For more information: www.buffalo.edu

Related Content

Turkish Hospital Begins MR-Guided Radiation Therapy With Viewray MRIdian Linac
News | Image Guided Radiation Therapy (IGRT) | September 21, 2018
ViewRay Inc. announced that Acibadem Maslak Hospital in Istanbul, Turkey has begun treating patients with ViewRay's...
Machine Learning IDs Markers to Help Predict Alzheimer's

Neurologists use structural and diffusion magnetic resonance imaging (MRI) to identify changes in brain tissue (both gray and white matter) that are characteristic of Alzheimer's disease and other forms of dementia. The MRI images are analyzed using morphometry and tractography techniques, which detect changes in the shape and dimensions of the brain and in the tissue microstructure, respectively. In this example, the images show the normal brain of an elderly patient. Image courtesy of Jiook Cha.

News | Neuro Imaging | September 20, 2018
New research has shown a combination of two different modes of magnetic resonance imaging (MRI), computer-based...
Ingenia Ambition X 1.5T MR. This innovation is the latest advance in the Ingenia MRI portfolio, which comprises fully-digital MRI systems, healthcare informatics and a range of maintenance and life cycle services for integrated solutions that empower a faster, smarter, and simpler path to enabling a confident diagnosis
News | Magnetic Resonance Imaging (MRI) | September 14, 2018
Philips, a global leader in health technology, launched the Ingenia Ambition X 1.5T MR.
Veye Chest version 2
News | Lung Cancer | September 11, 2018
Aidence, an Amsterdam-based medical AI company, announced that Veye Chest version 2, a class IIa medical device, has
Sponsored Content | Case Study | Magnetic Resonance Imaging (MRI) | September 07, 2018 | By Sabine Sartoretti, M.D.
As soon as the Compressed SENSE technology became available to the MRI team at Kantonsspital Winterthur (Switzerland),...

Image courtesy of Philips Healthcare

Feature | Magnetic Resonance Imaging (MRI) | September 06, 2018 | By Melinda Taschetta-Millane
According to the Prescient & Strategic Intelligence report, “Global Magnetic Resonance Imaging (MRI) Market Size,...
PET Imaging Agent Predicts Brain Tau Pathology, Alzheimer's Diagnosis
News | PET Imaging | September 05, 2018
Eli Lilly and Co. and Avid Radiopharmaceuticals Inc. announced a Phase 3 study of positron emission tomography (PET)...
Brain Iron Levels May Predict Multiple Sclerosis Disabilities
News | Neuro Imaging | August 31, 2018
A new, highly accurate magnetic resonance imaging (MRI) technique can monitor iron levels in the brains of multiple...
Study Finds Multiple Sclerosis Drug Slows Brain Shrinkage

An NIH-funded clinical trial suggested that the anti-inflammatory drug ibudilast may slow brain shrinkage caused by progressive MS. Image courtesy of Robert J. Fox, M.D., Cleveland Clinic.

News | Neuro Imaging | August 30, 2018
August 30, 2018 — Results from a clinical...
Rapid Cardiac MRI Technique May Cut Costs, Boost Care in Developing World
News | Magnetic Resonance Imaging (MRI) | August 29, 2018
A newly developed rapid imaging protocol quickly and cheaply diagnosed heart ailments in patients in Peru, according to...