Feature | Breast Imaging | October 28, 2019

Study Finds iCAD's ProFound AI Improves Efficiency and Accuracy in Breast Cancer Detection

Study finds use of AI was associated with improved accuracy and shorter reading times

CAD's ProFound AI Improves Efficiency and Accuracy in Breast Cancer Detection

October 28, 2019 — Artificial intelligence (AI) helps improve the efficiency and accuracy of an advanced imaging technology used to screen for breast cancer, according to a new study published in the journal Radiology: Artificial Intelligence.

Digital breast tomosynthesis (DBT) is an advanced method for cancer detection in which an X-ray arm sweeps over the breast, taking multiple images in a matter of seconds.

Research has shown that DBT improves cancer detection and reduces false-positive recalls compared to screening with digital mammography (DM) alone. However, the DBT exam can take almost twice as long to interpret as DM due to the time it takes for the radiologist to scroll through all the images. This increased time is likely to be more consequential as DBT increasingly becomes the standard-of-care for mammographic imaging.

For the study, researchers developed a deep learning system, a type of AI that can mine vast amounts of data to find subtle patterns beyond human recognition. They trained the AI system on large DBT data sets to identify suspicious findings in the DBT images.

After developing and training the system, the researchers tested its performance by having 24 radiologists, including 13 breast subspecialists, each read 260 DBT examinations with and without AI assistance. The examinations included 65 cancer cases.

Use of AI was associated with improved accuracy and shorter reading times. Sensitivity increased from 77 percent without AI to 85 percent with it. Specificity increased from 62.7 percent without AI to 69.6 percent with it. The recall rate for non-cancers, or the rate at which women were called back for follow-up examinations based on benign findings, decreased from 38 percent without AI to just 30.9 percent with it. On average, reading time decreased from just over 64 seconds without AI to only 30.4 seconds with it.

"Overall, readers were able to increase their sensitivity by 8 percent, lower their recall rate by 7 percent and cut their reading time in half when using AI concurrently while reading DBT cases compared to reading without using AI," said study lead author Emily F. Conant, M.D., professor and chief of breast imaging from the Department of Radiology at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia.

Also showing improvement was the area under the receiver operating characteristic curve (AUC), a graphing variable that combines sensitivity and specificity into a single measure for a better representation of overall radiologist performance. Radiologist performance, measured by mean AUC, increased from 0.795 without AI to 0.852 with AI.

"We know that DBT imaging increases cancer detection and lowers recall rate when added to 2-D mammography, and even further improvement in these key metrics is clinically very important," Conant said. "And, since adding DBT to the 2-D mammogram approximately doubles radiologist reading time, the concurrent use of AI with DBT increases cancer detection and may bring reading times back to about the time it takes to read DM-alone exams."

The researchers expect the deep learning approach to improve as it is exposed to larger and larger data sets, making its potential impact on patient care even more significant.

"The results of this study suggest that both improved efficiency and accuracy could be achieved in clinical practice using an effective AI system," Conant said.

For more information: www.pubs.rsna.org/journal/radiology

Related content: 

Breast Tomosynthesis Increases Cancer Detection Over Digital Mammography

 

Related Content

Videos | RSNA | January 13, 2020
ITN Editor Dave Fornell takes a tour of some of the most innovative new medical imaging technologies displayed on the
The study found that DBN laws helped some women understand they had increased breast density, but not that breast density is associated with a higher risk of breast cancer or that dense breasts limit the ability of mammograms to detect cancer
News | Breast Density | January 09, 2020
January 9, 2020 — A new study suggests that state-mandated notifications on...
Sponsored Content | Videos | Digital Radiography (DR) | January 06, 2020
An experienced technologist and two Agfa executives talk about what distinguishes the new Agfa 100s.
Sponsored Content | Videos | Ultrasound Imaging | January 06, 2020
The Arietta 850SE provides facilities with numerous features and functionality to get the most out of a system.
Sponsored Content | Videos | Computed Tomography (CT) | January 06, 2020
Hitachi announced the FDA clearance of its newest CT – Scenaria View – at RSNA2019.
Sponsored Content | Videos | Digital Radiography (DR) | January 03, 2020
At RSNA19, David Widmann, president and CEO of Konica Minolta Healthcare Americas, discussed innovation, stressing th