Feature | September 24, 2013

Adult Patients Under 50 With Limited Brain Metastases Have Better Survival After Stereotactic Radiosurgery Alone

ASTRO 2013 Clinical Study Limited Brain Metastases Stereotactic Radiosurgey

Adults under 50 with limited brain metastases have better survival after stereotactic radiosurgery alone.

September 24, 2013 — When treated with stereotactic radiosurgery (SRS), that is not combined with whole brain radiotherapy (WBRT), adult brain cancer patients who were 50 years old and younger were found to have improved survival, according to research presented at the American Society for Radiation Oncology’s (ASTRO’s) 55th Annual Meeting. Younger patients (under 50 years old) were also found to be at no greater risk of new brain metastases developing despite omission of WBRT.

A highly advanced brain cancer treatment, SRS utilizes precisely focused radiation beams to treat a tumor with a high dose while minimizing exposure to the surrounding healthy brain tissue. Another approach, often combined with SRS, is WBRT, which is radiation therapy applied to the entire brain. This individual patient data (IPD) meta-analysis was conducted on the patient data of three randomized clinical trials (RCTs) from North America [MDACC NCT00548756 (Chang, 2009)], Europe [EORTC 22952-26001 (Kocher, 2011)] and Asia [JRSOG99-1 (Aoyama, 2004)], with the aim to evaluate the results of SRS alone, compared to WBRT and SRS, for patients with one to four brain metastases. Patients in this study received one or both types of treatments.

A total of 364 patients from the three RCTs were evaluated. Of those, 51 percent had been treated with SRS alone, and 49 percent with both WBRT and SRS; 19 percent were 50 years old or younger and 60 percent had a single brain metastasis. Twenty-one percent of all patients had local brain failure, which is the occurrence of progression of previously treated brain metastases, and 44 percent had distant brain failure, the occurrence of new brain metastases in areas of the brain outside the primary tumor site(s). Eighty-six percent of the patients died during follow-up.

The analysis revealed that patients who received only SRS had a median of 10 months survival time after treatment, as opposed to 8.2 months survival time for patients who underwent WBRT in addition to SRS. Overall, local brain failure occurred earlier in patients who received only SRS (6.6 months post-treatment), as opposed to patients who underwent WBRT and SRS (7.4 months post-treatment). Distant brain failure was also earlier overall in patients who received only SRS, occurring at 4.5 months post-treatment, compared to 6.5 months post-treatment for patients who received both WBRT with SRS.

The impact of age on treatment effectiveness revealed SRS alone results in improved overall survival (OS) in patients 50 years old and younger. For patients age 35, 40, 45 and 50, the estimated hazard ratio and the corresponding 95 percent confidence intervals (CIs) were 0.46 (95% CI 0.24, 0.90), 0.52 (95% CI 0.29, 0.92), 0.58 (95% CI 0.35, 0.95) and 0.64 (95% CI 0.42, 0.99), respectively. With respect to distant brain failure, a significant association with age was also observed. Patients 50 years and younger were at no significantly greater risk of developing new tumors despite being treated with SRS alone.

“We expected to see a survival advantage favoring combined therapy, given the additional benefits of whole brain radiation, particularly with respect to increasing local control and reducing the risk of new brain metastases,” said lead study author Arjun Sahgal, M.D., an associate professor of radiation oncology at the University of Toronto and deputy chief of radiation oncology at Odette Cancer Centre, Sunnybrook Health Sciences Centre in Toronto. “Our study indicates, however, a survival advantage for SRS alone in younger patients who also interestingly were observed to have no greater risk of new brain metastases despite the omission of whole brain radiation. This implies that WBRT may not be required for all patients with brain metastases, particularly younger patients, and SRS alone should be considered as the favored first-line therapeutic option. The implications are significant as it has been shown in other studies that WBRT is detrimental to short term memory function and negatively impacts some aspects of patients’ quality of life.”

The abstract, “Individual Patient Data (IPD) Meta-Analysis of Randomized Controlled Trials (RCT) Comparing Stereotactic Radiosurgery Alone (SRS) to SRS plus Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastasis,” was presented Sept. 22, 2013.

For more information: www.astro.org

Related Content

New Prostate Cancer Radiotherapy Technique Aims to Preserve Sexual Function
News | Radiation Therapy | June 18, 2018
A multicenter clinical trial being led by UT Southwestern physicians is testing a technique for sparing nerve bundles...
Report Finds Identifying Patients for Lung Cancer Screening Not So Simple
News | Lung Cancer | June 18, 2018
New findings in the current issue of The American Journal of Managed Care suggest that getting the right patients to...
Elekta Unity High-Field MR-Linac Receives CE Mark
News | Image Guided Radiation Therapy (IGRT) | June 18, 2018
Elekta announced that its Elekta Unity magnetic resonance radiation therapy (MR/RT) system has received CE mark,...
Washington University in St. Louis Begins Clinical Treatments With ViewRay MRIdian Linac
News | Image Guided Radiation Therapy (IGRT) | June 14, 2018
June 14, 2018 — The Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in S
PET/CT Changes Care for 59 Percent of Suspected Recurrent Prostate Cancer Cases
News | Prostate Cancer | June 13, 2018
A recently presented investigational clinical trial evaluated the impact of 18F fluciclovine positron emission...
Accuray TomoTherapy System Beneficial in Two Total Body Irradiation Studies
News | Radiation Therapy | June 13, 2018
Recently published data from two new studies demonstrate the benefits of Accuray’s TomoTherapy System in the delivery...
Women More Likely to Use Other Preventive Health Services Following Mammography
News | Mammography | June 13, 2018
Medicare beneficiaries who undergo breast cancer screening with mammography are more likely than unscreened women to...
Reduced hippocampal volume on MRI

This figure shows reduced hippocampal volume over the course of 6 years as seen on progressive volumetric analysis and also coronal MRI evaluations (arrows).Progressive volume loss in the mesial temporal lobe on MRI is a characteristic imaging feature of AD. This patient was a case of Alzheimer’s Dementia.

 

News | Neuro Imaging | June 12, 2018
According to a UCLA Medical Center study, a new technology shows the potential to help doctors better determine when...
IsoRay Funding Brain Cancer Treatment Research With Ochsner Clinic Foundation
News | Brachytherapy Systems | June 12, 2018
IsoRay Inc. announced the initiation of research funding for brain cancer treatment to Ochsner Clinic Foundation, a not...
High Prevalence of Atherosclerosis Found in Lower Risk Patients
News | Magnetic Resonance Imaging (MRI) | June 08, 2018
Whole-body magnetic resonance angiography (MRA) found a surprisingly high prevalence of atherosclerosis in people...
Overlay Init