News | Oncology Related Products | May 06, 2016

Study Finds Breast Cancer Adjuvant Therapy Benefits Vary Over Time

Therapies completed years ago may not keep covering survivors

breast cancer, adjuvant therapy, clinical study, University of Texas Health Science Center

May 6, 2016 — After breast cancer surgery, women are prescribed adjuvant (or follow-up) therapies such as chemotherapy and endocrine drugs to reduce the risk of the cancer returning. It's been assumed that the treatment effects of these therapies remain constant over time, but a new study from the Cancer Therapy & Research Center (CTRC) at The University of Texas Health Science Center at San Antonio suggests the opposite is true.

The study, published in the Journal of the National Cancer Institute, looked at 19 breast cancer adjuvant therapy clinical trials of the National Surgical Adjuvant Breast and Bowel Project (NSABP). Therapies were evaluated for relative benefit, defined as the percentage by which they reduced recurrence and death among study participants.

Researchers found time-varying treatment effects of adjuvant therapies in nearly half of the trials (nine of 19). "In some trials, the benefit diminished at specific points of time after surgery," said study senior author Ismail Jatoi, M.D., Ph.D., FACS. "In other trials, there was no benefit early on, but then there was a delayed benefit that emerged more than one year after surgery."

In one clinical trial, the researchers found that a regimen provided initial benefit, but then a subsequent disadvantage, to patients, he said. Jatoi is the Dale H. Dorn Chair in Surgery in the School of Medicine at the UT Health Science Center, and serves as professor and chief of the Division of Surgical Oncology and Endocrine Surgery.

The findings may change the way oncologists talk to their patients about effects of treatments they are receiving, Jatoi said.

"We are seeing more and more long-term survivors of breast cancer who had these treatments many years ago," he said. "The question is, if these treatment effects have waned, should we consider extended adjuvant treatment regimens for the long term in some patients."

Adjuvant therapy trials should be designed and interpreted with this in mind, he added.

In 2011, Jatoi wrote a viewpoint article published in the Journal of Clinical Oncology in which he proposed that treatment effects of adjuvant therapy regimens might vary over time. He approached the NSABP, one of the nation's largest clinical trials groups, about doing a study.

NSABP statisticians Hanna Bandos, Ph.D., and Jong Hyeon Jeong, Ph.D., conducted much of the work and are co-authors of the study.

For more information: www.jnci.oxfordjournals.org

Related Content

Registration is now open for the Radiological Society of North America (RSNA) 107th Scientific Assembly and Annual Meeting, the world’s largest annual radiology forum, to be held at McCormick Place Chicago, Nov. 28 – Dec. 2, 2021

Getty Images

News | RSNA | July 21, 2021
July 21, 2021 — Registration is now open for the Radiological Society of North America (...
According to ARRS’ American Journal of Roentgenology (AJR), return to routine screening for BI-RADS 3 lesions on supplemental automated whole-breast US (ABUS) substantially reduces the recall rate, while being unlikely to result in adverse outcome

Normal right mediolateral oblique (A) and craniocarudal (B) view screening mammograms demonstrate density C breasts. Coronal (C), transverse (D), and reconstructed lateral (E) views from supplemental automatic breast ultrasound (ABUS) demonstrates 7 mm circumscribed slightly hypoechoic circumscribed lesion at 11 o’clock position in right breast. Lesion was classified as BI-RADS 3. Patient has undergone yearly mammograms for 4 years following the ABUS examination with no breast cancer diagnosis.

News | Breast Imaging | July 16, 2021
July 16, 2021 —...
Volpara now holds 98 granted patents across 27 countries
News | Breast Imaging | July 16, 2021
July 16, 2021 — Volpara has recently been granted another patent by the...
Interviews with the 1,000 at-risk patients also led to some interesting conclusions, Fine said. Even in the early days of 3D mammography, most women interviewed had at least heard about the technology.

Getty Images

News | Mammography | July 15, 2021
July 15, 2021 —  For any type of diagnostic test, technology that helps improve the reliability of test results is a
ujifilm's robust medical systems portfolio includes a comprehensive product lineup covering CT, MRI, fluoroscopy, digital radiography, women’s health, ultrasound, systems integration, endoscopy and endosurgery, enterprise imaging, assisted reproductive technology, cell culture media, cell therapy development, In-Vitro diagnostics (IVD), and investigational drug development
News | Radiology Imaging | July 14, 2021
July 14, 2021 — Fujifilm announced the launch of the ...
A new study set out to learn more about breast health for Black women and to establish a better understanding of the breast screening landscape by analyzing mammograms, screening intervals and interpretation performance for Asian, Black and white women across health systems throughout the United States, with participation from Advocate Health Care, Sanford Health and the University of Pennsylvania Health System.

Getty Images

Feature | Breast Imaging | July 06, 2021 | By Linda Goler Blount, MPH
Due to dangerous implications for years to come, facilities must increase efficiency and capacity for breast cancer care to recover from the impact of COVID-19

Getty Images

Feature | Breast Imaging | July 06, 2021 | By Ananth Ravi, Ph.D.
The challenges
Breast cancer recently surpassed lung cancer as the number 1 diagnosed cancer in the U.S., excluding nonmelanoma skin cancer. Additionally, the National Cancer Institute recently predicted an almost 10,000 excess deaths from breast and colorectal cancers over the next 10 years as a direct result of the pandemic, making it now more important than ever for women to take control over their breast health.
News | Artificial Intelligence | June 25, 2021
June 25, 2021 — Breast cancer recently ...
According to a new study, by the Harvey L. Neiman Health Policy Institute and the American College of Radiology’s National Mammography Database Committee, the most influential radiologist characteristics impacting mammography interpretive performance were geography, breast sub-specialization, performance of diagnostic mammography, and performance of diagnostic ultrasound.

Getty Images

News | Breast Imaging | June 23, 2021
June 23, 2021 — According to a new ...