News | December 14, 2006

Quest Launches Test to Predict Breast Cancer Recurrence

Quest Diagnostics Inc. has introduced its newly developed test, the Breast Cancer Gene Expression Ratio, to help physicians predict the risk of disease recurrence in women with estrogen receptor-positive, lymph node-negative breast cancer. Quest Diagnostics is the first company to develop a breast cancer recurrence test based on licensed gene-expression profiling technology from AviaraDx Inc., a molecular cancer profiling company.

The Breast Cancer Gene Expression Ratio is based on the homeobox gene-B13 (HOXB13) and the interleukin-17B receptor gene (IL17BR). In breast cancers that are more likely to recur, the HOXB13 gene tends to be over-expressed, while the IL-17BR gene tends to be under-expressed. In an 852-patient retrospective study published recently in the Journal of Clinical Oncology, the HOXB13:IL17BR ratio (H:I expression ratio) independently predicted breast cancer recurrence in patients with ER-positive, lymph-node negative cancer. The H:I expression ratio was found to be predictive in patients who received tamoxifen therapy as well as in those who did not.

Related Content

News | March 26, 2015
March 26, 2015 — Siemens Healthcare introduced a new angiography system and new cardiac ultrasound apps at the 2015...

The smallest point-of-care ultrasound platform available is the Vscan, released earlier this year by GE Healthcare. The device is about the size of a personal digital assistant (PDA) device.

Feature | December 13, 2010 | Andrew Zawadowski, M.D., FRCPC, FACC, FESC, FAHA
In the same fashion that the echocardiogram helped transform the cardiac exam, recent developments in the field of...
News | August 06, 2008
August 7, 2008 - A new software enhancement for Nova StatStrip Glucose and StatSensor Creatinine point-of-care monito
News | June 15, 2008
June 16, 2008 - 3M Health Care said today its 3M Rapid Detection Flu A B Test demonstrated better clinical and analyt
News | April 20, 2008
April 21, 2008 - One day soon a biosensing nanodevice developed by Arizona State University researcher Wayne Frasch m
News | March 25, 2008
March 26, 2008 - A new, low-cost hospital blood glucose meter from Nova Biomedical provides the same analytical perfo
News | March 11, 2008
March 12, 2008 – The Committee to Reduce Infection Deaths says a new study in the Journal of the American Medical Ass
News | March 09, 2008
March 10, 2008 - Testing hospitalized patients for drug-resistant infections can help reduce mortality, decrease leng
News | March 03, 2008
March 3, 2008 - Nova Biomedical said today its StatStrip point-of-care blood glucose monitoring system has received F
News | February 18, 2008
February 19, 2008 – Masimo announced today that the National Fire Protection Association (NFPA) has included carbon m