News | August 05, 2007

MR Outperforms FFDM, US in High-Risk Breast Cancer Screenings

August 6, 2007 - Breast MRI enables radiologists to improve identification of tumors missed by mammography and ultrasound, according to a new study, ‘Cancer Yield of Mammography, MR and US in High-Risk Women: Prospective Multi-Institution Breast Cancer Screening Study,’ published in the August issue of the journal Radiology. The multi-center study compared the three imaging modalities in women at high risk for breast cancer. The researchers estimated that, compared to mammography and ultrasound, screening with MRI will allow detection of 23 more cancers per 1,000 high-risk women screened.

"Women at high risk for breast cancer can benefit from undergoing screening MRI," said the study's lead author, Constance Dobbins Lehman, M.D., Ph.D., director of radiology at the Seattle Cancer Care Alliance and professor of radiology at the University of Washington School of Medicine. "Of all the breast imaging tools we have currently available, MRI is clearly the best at detecting cancer."

For this study, researchers at six facilities studied 171 asymptomatic women over age 25 (average age 46) with at least a 20 percent lifetime risk of developing breast cancer to compare screening performance of MRI and mammography in high-risk patients. Each of the women underwent MRI, mammography and ultrasound.

Sixteen biopsies were performed, and six cancers were detected for an overall cancer yield of 3.5 percent. All six of the cancers were detected with MRI, while two cancers were detected with mammography and only one cancer was detected with ultrasound. The four cancers found in women with dense breast tissue were only detected with MRI. Biopsy rates were 8.2 percent for MRI and 2.3 percent for mammography and ultrasound. The positive predictive value (PPV) of biopsies performed as a result of MRI findings was 43 percent.

A previous study by Dr. Lehman (‘Breast MR Imaging: Computer Aided Evaluation (CAE) Program for Discriminating Benign and Malignant Lesions,' published in the July Radiology) indicated that by using computer-aided detection (CADstream) technology with breast MRI, discrimination of benign and malignant lesions can be improved and the number of false positives and unnecessary biopsies can be reduced.

“Computer software programs such as the one evaluated in our study can assist us in interpreting breast MRI scans more easily,” said Dr. Lehman. Our study suggests that the information provided may improve our ability to distinguish between benign and malignant lesions.”

Source: RSNA

For more information: www.rsna.org

Related Content

Sponsored Content | Videos | Breast Imaging | July 28, 2017
Nancy Cappello, Ph.D., executive director and founder of Are You Dense Inc. and Are You Dense Advocacy, explains how
MRI Plus Mammography Improves Detection of New Breast Cancer After Surgery
News | Breast Imaging | June 22, 2017
A new article published by JAMA Oncology compares outcomes for combined mammography and magnetic resonance imaging (MRI...
Radiology journal, breast MRI screening, average risk women, breast cancer

Images in a 55-year-old screening participant. (a, b) Normal digital full-field mediolateral oblique (a) and craniocaudal (b) mammograms (BI-RADS category 1) show a heterogeneously dense breast (ACR category C). (c) Screening ultrasound image shows normal findings (BI-RADS category 1). (d) MR-guided biopsy enabled us to confirm the presence of an invasive high-grade triple-negative cancer (no special type [NST], pT1b, N0, M0). (d) Breast MR image shows a suspicious enhancing mass (arrow) in the left breast (BI-RADS category 5). Image courtesy of the Radiological Society of North America.

News | MRI Breast | February 21, 2017
Magnetic resonance imaging (MRI) screening improves early diagnosis of breast cancer in all women, not only those at...
Rapid Breast MRI, breast cancer screening, David Strahle, RMI, Breast Cancer Research and Treatment study
News | MRI Breast | February 10, 2017
February 10, 2017 — A new method for screening women with dense breast tissue may potentially save thousands of lives
breast MRI, new AB-MR exam protocol, Via Radiology, cancer detection, dense breasts, women's health
News | MRI Breast | February 07, 2017
A newly developed breast magnetic resonance imaging (MRI) exam protocol, the first of its kind being offered in the...
News | MRI Breast | June 27, 2016
A new phase 1 clinical trial from Brigham and Women's Hospital published in Radiology on June 22 evaluated the...
breast MRI, ER-positive breast cancer detection, Case Western Reserve study

Differences in dynamic textural patterns are apparent between a patient with a low recurrence score, left, and a patient with a high recurrence score, right. Image courtesy of Nature Scientific Reports

News | MRI Breast | February 19, 2016
February 19, 2016 — A new way to analyze magnet...

Molecular imaging of the GRPR biomarker on mice xenografted with PC3 and H441 cells by T1-weighted spin echo MR imaging and NIR imaging.

News | Magnetic Resonance Imaging (MRI) | December 29, 2015
December 29, 2015 — A method to better trace changes in cancers and treatment of the prostate and lung without the li
Overlay Init